Deepali Gupta, Ph.D. Titles and Appointments Instructor Schools Medical School Departments Peter O'Donnell Jr. Brain Institute | Neuroscience Biography Deepali Gupta, Ph.D., is an Instructor in the Dauer Lab, Peter O'Donnell Jr. Brain Institute | Neuroscience, UT Southwestern Medical Center. Currently, Dr. Gupta’s research focuses on the molecular and cellular mechanisms underlying dystonia, a neurological movement disorder. Her research investigates the role of torsin proteins implicated in DYT1 dystonia, and the molecular pathways contributing to disease pathogenesis. Her research seeks to advance understanding of dystonia pathogenesis and support the development of improved therapeutic strategies. Originally from India, Dr. Gupta earned her bachelor’s degree in Pharmacy from Rajiv Gandhi Technical University in Madhya Pradesh, India, followed by a master’s degree in Pharmacology from the Birla Institute of Technology and Science (BITS), Pilani, Rajasthan. She subsequently earned her doctorate in Neuropharmacology from BITS Pilani. Dr. Gupta joined UT Southwestern Medical Center for postdoctoral training under the mentorship of Jeffrey Zigman, Ph.D., where she investigated the biological functions and signaling pathways of the ghrelin system. Dr. Gupta has contributed to 44 peer-reviewed publications and a book chapter and has presented her findings at scientific conferences in the United States and internationally. She has been involved in professional organizations, including the International Society for Neurochemistry, The Obesity Society, and the American Diabetes Association, where she has served on the Membership Committee. Throughout her doctoral and postdoctoral training, Dr. Gupta has mentored high school, graduate, and postgraduate students. She also serves as an ad hoc reviewer for several peer-reviewed scientific journals. Personal Note Outside the laboratory, Dr. Gupta enjoys spending time with her children and family. She has also volunteered at blood donation camps in India, supporting community efforts to promote blood donation and help those in need. Research Interest Motor disorders (Dystonia) and Neurobehaviors Neuroendocrine Research Publications Featured Publications High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets. Gupta D, Dowsett GKC, Mani BK, Shankar K, Osborne-Lawrence S, Metzger NP, Lam BYH, Yeo GSH, Zigman JM, Endocrinology 2021 Oct 162 10 LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Shankar K, Metzger NP, Singh O, Mani BK, Osborne-Lawrence S, Varshney S, Gupta D, Ogden SB, Takemi S, Richard CP, Nandy K, Liu C, Zigman JM, Mol Metab 2021 Aug 101327 Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions. Gupta D, Patterson AM, Osborne-Lawrence S, Bookout AL, Varshney S, Shankar K, Singh O, Metzger NP, Richard CP, Wyler SC, Elmquist JK, Zigman JM, Mol Metab 2021 May 53 101258 Acyl-ghrelin is Permissive for the Normal Counterregulatory Response to Insulin-induced Hypoglycemia. Shankar K, Gupta D, Mani BK, Findley BG, Lord CC, Osborne-Lawrence S, Metzger NP, Pietra C, Liu C, Berglund ED, Zigman JM, Diabetes 2019 Nov ?1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals. Mani BK, Osborne-Lawrence S, Vijayaraghavan P, Hepler C, Zigman JM J. Clin. Invest. 2016 Sep 126 9 3467-3478 A novel 5HT3 antagonist 4i (N-(3-chloro-2-methylphenyl)quinoxalin-2-carboxamide) prevents diabetes-induced depressive phenotypes in mice: Modulation of serotonergic system. Gupta D, Thangaraj D, Radhakrishnan M, Behav Brain Res 2016 Jan 297 41-50 Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice. Gupta D, Radhakrishnan M, Kurhe Y, Steroids 2015 Apr 96 95-102 Ondansetron, a 5HT3 receptor antagonist reverses depression and anxiety-like behavior in streptozotocin-induced diabetic mice: possible implication of serotonergic system. Gupta D, Radhakrishnan M, Kurhe Y, Eur J Pharmacol 2014 Dec 744 59-66 Insulin reverses anxiety-like behavior evoked by streptozotocin-induced diabetes in mice. Gupta D, Radhakrishnan M, Kurhe Y, Metab Brain Dis 2014 Sep 29 3 737-46 Antidepressant effects of insulin in streptozotocin induced diabetic mice: Modulation of brain serotonin system. Gupta D, Kurhe Y, Radhakrishnan M, Physiol Behav 2014 Apr 129 73-8 Results 1-10 of 10 1 Books Featured Books Antidepressant Therapy for Depression: An Update. Understanding Depression Gupta D, Radhakrishnan M. (2018). Singapore, Springer Honors & Awards Postgraduate Travel Award for 14th Meeting on Asian-Pacific Society for Neurochemistry, MalaysiaAsian-Pacific Society for Neurochemistry (2016) ISN travel Award for 25th ISN-APSN Biennial Meeting in Cairns, AustraliaInternational Society of Neurochemistry (2015) Travel Award for 21st World Congress on Parkinson Disease & Related DisordersInternational Association of Parkinson Disease & Related Disorders (IAPRD), Milan, Italy (2015) Travel Award, for AAPS, Student Chapter, SingaporeDepartment of Biotechnology, Government of India (2015) Travel Award for 15th International Conference on Pharmacy and Pharmacology, World Academy of Science Engineering and Technology, London, UKDepartment of Science and Technology, Government of India (2014) University Grant Commission India-Basic Scientific Research FellowshipDepartment of Biotechnology, India (2012-2015) Young scientist and Best Poster AwardPharma-next Conference, India (2012) Sir, Ratan TATA Scholarship for Graduate Students (2006-2008) Professional Associations/Affiliations International Brain Research Organization (IBRO) (2016-2017) International Society for Neurochemistry (ISN) (2015) The American Diabetes Association (2019) The Endocrine Society (2019) The Obesity Society (2019-2021)
