Madhukar Trivedi is Professor of Psychiatry, Chief of the Division of Mood Disorders, and Director of the Center for Depression Research and Clinical Care at UT Southwestern Medical Center. He earned his MBBS and MS in Baroda, India, completing his residencies in Psychiatry at University General Hospital, Baroda, India and Henry Ford Hospital, Detroit, Michigan. He completed his fellowship at UT Southwestern, where he now serves as Betty Jo Hay Distinguished Chair in Mental Health and Julie K. Hersh Chair for Depression Research and Clinical Care. Certified by the American Board of Psychiatry and Neurology, Dr. Trivedi is an established clinical and translational researcher with extensive experience serving as PI and Co-PI on several single and multi-site clinical trials funded by NIH, foundations and industry sponsors.
Dr. Trivedi’s research over the last 25 years has focused on understanding the neurobiology and psychology of depression and bipolar disorder, with a particular focus on developing an empirical basis for improving treatment of depression. Dr. Trivedi and his team have been involved in many of the pivotal studies involving the establishment of efficacy of antidepressant treatments (medications, psychotherapy, exercise, complimentary treatments, devices, etc.), examining next steps in treatment resistant depression to develop algorithms and guidelines, and developing and validating biomarkers in order to reach the goal of precision medicine for mood disorders. Among his most notable studies are the Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) trial, Combining Medications to Enhance Depression Outcomes (CO-MED) trial, Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, and the Texas Resilience Against Depression (T-RAD) study.
His numerous awards include the National Depressive and Manic-Depressive Association Scientific Advisory Board, the Psychiatric Excellence Award from the Texas Society of Psychiatric Physicians (TSPP), the Gerald Klerman Senior Investigator Award, the American Psychiatric Association (APA) Award for Research, and the American College of Psychiatrists (ACP) Award for Research in Mood Disorders. For six consecutive years, Dr. Trivedi has been named a Global Highly Cited Researcher by Clarivate Analytics. He is also a member of numerous other professional organizations, including the American College of Neuropsychopharmacology (ACNP), the American College of Psychiatrists (ACP), the American Medical Association (AMA), the American Psychiatric Association (APA), the Dallas County Medical Society, the Society of Biological Psychiatry (SBP), the Texas Medical Association (TMA), and the Texas Society of Psychiatric Physicians (TSPP). Dr. Trivedi currently serves as Deputy Editor of the American Journal of Psychiatry and as president of the American Society of Clinical Psychopharmacology (ASCP).
- Medical School
- Baroda Medical College (1980)
- S.S. General Hospital (1981), Psychiatry
- University General Hospital (1985), Psychiatry
- Henry Ford Health Systems (1990), Psychiatry
- UT Southwestern Medical Center (1993), Psychiatry
- Evidence based psychopharmacology and treatment algorithms in Mood Disorders
- Functional Brain Imaging in Major Depressive and Obsessive Compulsive Disorders
- Neurobiology and Psychopharmacology of Depression and Bipolar Disorder
- Modeling predictors, moderators and mediators of treatment outcome and resistance in depression.
- Trivedi MH Biol. Psychiatry 2013 Jul 74 1 2-4
- Increase in work productivity of depressed individuals with improvement in depressive symptom severity.
- Trivedi MH, Morris DW, Wisniewski SR, Lesser I, Nierenberg AA, Daly E, Kurian BT, Gaynes BN, Balasubramani GK, Rush AJ Am J Psychiatry 2013 Jun 170 6 633-41
- Evidence-based recommendations for the prescription of exercise for major depressive disorder.
- Rethorst CD, Trivedi MH J Psychiatr Pract 2013 May 19 3 204-12
- Clinical and sociodemographic characteristics associated with suicidal ideation in depressed outpatients.
- Trivedi MH, Morris DW, Wisniewski SR, Nierenberg AA, Gaynes BN, Kurian BT, Warden D, Stegman D, Shores-Wilson K, Rush AJ Can J Psychiatry 2013 Feb 58 2 113-22
- Exercise as an augmentation treatment for nonremitted major depressive disorder: a randomized, parallel dose comparison.
- Trivedi MH, Greer TL, Church TS, Carmody TJ, Grannemann BD, Galper DI, Dunn AL, Earnest CP, Sunderajan P, Henley SS, Blair SN J Clin Psychiatry 2011 May 72 5 677-84
- The current crisis of confidence in antidepressants.
- Nierenberg AA, Leon AC, Price LH, Shelton RC, Trivedi MH J Clin Psychiatry 2011 Jan 72 1 27-33
- Stimulant reduction intervention using dosed exercise (STRIDE) - CTN 0037: study protocol for a randomized controlled trial.
- Trivedi MH, Greer TL, Grannemann BD, Church TS, Somoza E, Blair SN, Szapocznik J, Stoutenberg M, Rethorst C, Warden D, Ring KM, Walker R, Morris DW, Kosinski AS, Kyle T, Marcus B, Crowell B, Oden N, Nunes E Trials 2011 12 206
- Association between major depressive episodes in patients with chronic kidney disease and initiation of dialysis, hospitalization, or death.
- Hedayati SS, Minhajuddin AT, Afshar M, Toto RD, Trivedi MH, Rush AJ JAMA 2010 May 303 19 1946-53
- Bupropion-SR, Sertraline, or Venlafaxine-XR after Failure of SSRIs for Depression
- Rush, A.J., Trivedi, M.H., Wisniewski, S.R., Stewart, J.W., Nierenberg, A., Thase, M.E., Ritz, L., Biggs, M.M., Warden, D., Luther, J.F., Shores-Wilson, K., Niederehe, G., Fava, M. New England Journal of Medicine Spring 2006 354 1231-42
- Medication Augmentation after the Failure of SSRIs for Depression
- Trivedi, M.H., Fava, M., Wisniewski, S.R., Thase, M.E., Quitkin, F., Warden, D., Ritz, L., Nierenberg, A.A., Lebowitz, B.D., Biggs, M.M., Luther, J. F., Shores-Wilson, K., Rush, A.J. New England Journal of Medicine Spring 2006 354 1243-52
Primer on Depression
(Ed.) (2019). New York, NY, Oxford University Press
Managing Relapse in Depression
Nierenberg, A.A., Sussman, N., Trivedi, MH (2003). London, UK, Science Press Ltd
Computerized Medication Algorithms in Behavioral Health Care. In Behavioral Health Care Informatics
Trivedi, MH, Kern, J.K., Voegtle, T.M., Baker, S.M., Altshuler. K.Z. (2001). NewYork, NY, Springer-Verlag NewYork Inc
Honors & Awards
- 2020 Excellence in Healthcare Award
D CEO Magazine (2020)
- Dallas Future 50 list
Dallas Innovates 2020: The Magazine (2020)
American Society of Clinical Psychopharmacology (2020)
- Scientific Advisor
American Foundation for Suicide Prevention (2020)
American Society of Clinical Psychopharmacology (2019)
- Worlds Most Influential Scientific Minds / Highly Cited Researcher
Clarivate Analytics (former Thomson Reuters) (2019)
- Outstanding Academician Award
Indo American Psychiatric Association (IAPA) (2005)
- Honorary International Advisory Member
The Chinese Pharmacology Algorithm Project (2002)
- Psychiatric Excellence Award
Texas Society of Psychiatric Physicians (TSPP) (2002)
- Gerald L. Klerman Young Investigator Award
National Depressive and Manic-Depressive Association Scientific Advisory Board (2000)
- Depression Specific Content Expert, Evidence Based Report Center (San Antonio)
Agency for Health Care Policy and Research , U.S. Dept of Health and Human Services (1997)
- International Society for Bipolar Disorders (2018)
- American Society of Clinical Psychopharmacology (2009)
- The American College of Psychiatrists (2002)
- American Medical Association (1995)
- Dallas County Medical Society (1995)
- Society of Biological Psychiatry (1995)
- ACNP American College of Neuropsychopharmacology
- American Psychiatric Association
- Texas Medical Association
- Texas Society of Psychiatric Physicians