Madhukar Trivedi, M.D. Titles and Appointments Professor Endowed Title Betty Jo Hay Distinguished Chair in Mental Health; Julie K. Hersh Chair for Depression Research and Clinical Care School Medical School Department Psychiatry | Public Health Graduate Programs Clinical Psychology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Madhukar Trivedi is Professor of Psychiatry, Chief of the Division of Mood Disorders, and Director of the Center for Depression Research and Clinical Care at UT Southwestern Medical Center. He earned his MBBS and MS in Baroda, India, completing his residencies in Psychiatry at University General Hospital, Baroda, India and Henry Ford Hospital, Detroit, Michigan. He completed his fellowship at UT Southwestern, where he now serves as Betty Jo Hay Distinguished Chair in Mental Health and Julie K. Hersh Chair for Depression Research and Clinical Care. Certified by the American Board of Psychiatry and Neurology, Dr. Trivedi is an established clinical and translational researcher with extensive experience serving as PI and Co-PI on several single and multi-site clinical trials funded by NIH, foundations and industry sponsors. Dr. Trivedi’s research over the last 25 years has focused on understanding the neurobiology and psychology of depression and bipolar disorder, with a particular focus on developing an empirical basis for improving treatment of depression. Dr. Trivedi and his team have been involved in many of the pivotal studies involving the establishment of efficacy of antidepressant treatments (medications, psychotherapy, exercise, complimentary treatments, devices, etc.), examining next steps in treatment resistant depression to develop algorithms and guidelines, and developing and validating biomarkers in order to reach the goal of precision medicine for mood disorders. Among his most notable studies are the Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) trial, Combining Medications to Enhance Depression Outcomes (CO-MED) trial, Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, and the Texas Resilience Against Depression (T-RAD) study. His numerous awards include the National Depressive and Manic-Depressive Association Scientific Advisory Board, the Psychiatric Excellence Award from the Texas Society of Psychiatric Physicians (TSPP), the Gerald Klerman Senior Investigator Award, the American Psychiatric Association (APA) Award for Research, and the American College of Psychiatrists (ACP) Award for Research in Mood Disorders. For six consecutive years, Dr. Trivedi has been named a Global Highly Cited Researcher by Clarivate Analytics. He is also a member of numerous other professional organizations, including the American College of Neuropsychopharmacology (ACNP), the American College of Psychiatrists (ACP), the American Medical Association (AMA), the American Psychiatric Association (APA), the Dallas County Medical Society, the Society of Biological Psychiatry (SBP), the Texas Medical Association (TMA), and the Texas Society of Psychiatric Physicians (TSPP). Dr. Trivedi currently serves as Deputy Editor of the American Journal of Psychiatry and as president of the American Society of Clinical Psychopharmacology (ASCP). Education Medical School Baroda Medical College (1980) Internship S.S. General Hospital (1981), Psychiatry Residency University General Hospital (1985), Psychiatry Residency Henry Ford Health Systems (1990), Psychiatry Fellowship UT Southwestern Medical Center (1993), Psychiatry Research Interest Evidence based psychopharmacology and treatment algorithms in Mood Disorders Functional Brain Imaging in Major Depressive and Obsessive Compulsive Disorders Neurobiology and Psychopharmacology of Depression and Bipolar Disorder Publications Featured Publications Characterizing inflammatory profiles of suicidal behavior in adolescents: Rationale and design. Chin Fatt C, Ayvaci ER, Jha MK, Emslie G, Gibson S, Minhajuddin AT, Mayes TL, Farrar JD, Trivedi MH, J Affect Disord 2023 Mar 325 55-61 Youth Aware of Mental Health (YAM) Program With Texas Adolescents: Depression, Anxiety, and Substance Use Outcomes. Trivedi MH, Nandy K, Mayes TL, Wang T, Forbes K, Anderson JR, Fuller A, Hughes JL, J Clin Psychiatry 2022 May 83 4 Cross-Sectional Associations Among Symptoms of Pain, Irritability, and Depression and How These Symptoms Relate to Social Functioning and Quality of Life: Findings From the EMBARC and STRIDE Studies and the VitalSign6 Project. Jha MK, Schatzberg A, Minhajuddin A, Chin Fatt C, Mayes TL, Trivedi MH, J Clin Psychiatry 2021 Apr 82 3 Bupropion and Naltrexone in Methamphetamine Use Disorder. Trivedi MH, Walker R, Ling W, Dela Cruz A, Sharma G, Carmody T, Ghitza UE, Wahle A, Kim M, Shores-Wilson K, Sparenborg S, Coffin P, Schmitz J, Wiest K, Bart G, Sonne SC, Wakhlu S, Rush AJ, Nunes EV, Shoptaw S, N Engl J Med 2021 01 384 2 140-153 Psychometric properties of the concise health risk tracking (CHRT) in adolescents with suicidality. Mayes TL, Kennard BD, Killian M, Carmody T, Grannemann BD, Rush AJ, Jha MK, Hughes J, Emslie GJ, Trivedi MH J Affect Disord 2018 Mar 235 45-51 Problematic social media use and relationship to mental health characteristics in youth from the Texas Youth Depression and Suicide Research Network (TX-YDSRN) Betsy D. Kennard, Jennifer L. Hughes, Abu Minhajuddin, Sophia M. Jones, Manish K. Jha, Holli Slater, Taryn L. Mayes, Eric A. Storch, Jacquelyn M. LaGrone, Sarah L. Martin, Jessica L. Hamilton, Rebecca Wildman, Shamari Pitts, Joseph C. Blader, Blake M. Upshaw, E'Lenya K. Garcia, Sarah M. Wakefield, Madhukar H. Trivedi J Affect Disord. 2025 Characterizing Measurement-Based Care in the Texas Youth Depression and Suicide Research Network (TX-YDSRN). Slater H, AlZubi Y, Rezaeizadeh A, Hughes JL, Gorman A, Mayes TL, Elmore JS, Storch EA, Wakefield SM, Trivedi MH, Child Psychiatry Hum Dev 2024 Feb Treatment of Adolescent Depression: Comparison of Psychiatric and Pediatric Settings at an Academic Medical Center Using the VitalSign6 Application. Ayvaci ER, Minhajuddin A, Elmore JS, Yagnik K, Jha MK, Emslie GJ, Mayes TL, Trivedi MH, J Child Adolesc Psychopharmacol 2024 Jan Predicting suicidal events: A comparison of the Concise Health Risk Tracking Self-Report (CHRT-SR) and the Columbia Suicide Severity Rating Scale (C-SSRS). Mayes TL, Carmody T, Rush AJ, Nandy K, Emslie GJ, Kennard BD, Forbes K, Jha MK, Hughes JL, Heerschap JK, Trivedi MH, Psychiatry Res 2023 Jun 326 115306 Predictors of response and remission in patients with treatment-resistant depression: A post hoc pooled analysis of two acute trials of esketamine nasal spray. Turkoz I, Nelson JC, Wilkinson ST, Borentain S, Macaluso M, Trivedi MH, Williamson D, Sheehan JJ, Salvadore G, Singh J, Daly E, Psychiatry Res 2023 May 323 115165 Results 1-10 of 645 1 2 3 4 5 Next Last Books Featured Books Major Depressive Disorder: A Measurement Based Approach. In How to Practice Evidence-Based Psychiatry Trivedi, M.H. Kurian, B. (2010). Washington, D.C. and London, England, American Psychiatric Publishing, Inc. Primer on Depression. In Depression Trivedi, Madhukar H. Greer, Tracy L. Mayes, Taryn L. (Ed.) (2019). New York, NY, Oxford University Press Managing Relapse in Depression Nierenberg, A.A., Sussman, N., Trivedi, MH (2003). London, UK, Science Press Ltd Computerized Medication Algorithms in Behavioral Health Care. In Behavioral Health Care Informatics Trivedi, MH, Kern, J.K., Voegtle, T.M., Baker, S.M., Altshuler. K.Z. (2002). NewYork, NY, Springer-Verlag NewYork Inc Treatment-Refractory Depression. In Antidepressants: Past, Present and Future Trivedi, M. Bettinger, T. Kleiber, B. (2004). Springer Berlin, Heidelberg Depression. In Encyclopedia of Exercise Medicine in Health and Disease Rethorst, Chad D. Greer, Tracy L. Trivedi, Madhukar H. (2012). Springer Berlin, Heidelberg Biomarkers Predicting Antidepressant Treatment Response. In Depression Israel, Sonia Benrimoh, David Daniels, Sylvanne Turecki, Gustavo Gadad, Bharathi S. Jha, Manish K. Trivedi, Madhukar H. (2019). Oxford University Press Which therapy for which patient?. In Antidepressants and Major Depressive Disorder Greer, Tracy L. Kurian, Benji T. Trivedi, Madhukar H. (2012). Future Medicine Ltd. Biomarker-Based Treatment Selection: A Precision Medicine Approach for Depression. In Neurobiology of Depression Furman, Jennifer L. Trivedi, Madhukar H. (2019). Academic Press Precision Medicine for the Treatment of Depression. In Depression Diederich, Andrew Jones, Jessica M. Emslie, Graham J. Trivedi, Madhukar H. Kahalnik, Farra Greer, Tracy L. (2019). Oxford University Press Honors & Awards 2020 Excellence in Healthcare AwardD CEO Magazine (2020) DallasÂ’ Future 50 listDallas Innovates 2020: The Magazine (2020) FellowMemberAmerican Society of Clinical Psychopharmacology (2020) Scientific AdvisorAmerican Foundation for Suicide Prevention (2020) PresidentAmerican Society of Clinical Psychopharmacology (2019) WorldÂ’s Most Influential Scientific Minds / Highly Cited ResearcherClarivate Analytics (former Thomson Reuters) (2019) Outstanding Academician AwardIndo American Psychiatric Association (IAPA) (2005) Honorary International Advisory MemberThe Chinese Pharmacology Algorithm Project (2002) Psychiatric Excellence AwardTexas Society of Psychiatric Physicians (TSPP) (2002) Gerald L. Klerman Young Investigator AwardNational Depressive and Manic-Depressive Association Scientific Advisory Board (2000) Depression Specific Content Expert, Evidence Based Report Center (San Antonio)Agency for Health Care Policy and Research , U.S. Dept of Health and Human Services (1997) Professional Associations/Affiliations ACNP American College of Neuropsychopharmacology American Medical Association (1995) American Psychiatric Association American Society of Clinical Psychopharmacology (2009) Dallas County Medical Society (1995) International Society for Bipolar Disorders (2018) Society of Biological Psychiatry (1995) Texas Medical Association Texas Society of Psychiatric Physicians The American College of Psychiatrists (2002)
