Srinivas obtained his Ph.D. from The University of Texas at Austin and then joined Memorial Sloan Kettering Cancer Center as an American Cancer Society Fellow with Dr. Joan Massague.
Dr. Malladi’s lab in the Department of Pathology is focused on understanding how disseminated cancer cells survive and give rise to overt metastasis at a cellular and molecular level using a multidisciplinary and integrative approach.
- Cancer Invasion and Metastasis
- Metastatic Stem Cells
- Tumor Biology and Microenvironment
- The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.
- Choi YE, Butterworth M, Malladi S, Duckett CS, Cohen GM, Bratton SB J. Biol. Chem. 2009 May 284 19 12772-82
- Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c.
- Fisher AA, Labenski MT, Malladi S, Gokhale V, Bowen ME, Milleron RS, Bratton SB, Monks TJ, Lau SS Biochemistry 2007 Oct 46 39 11090-100
- Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease.
- Challa M, Malladi S, Pellock BJ, Dresnek D, Varadarajan S, Yin YW, White K, Bratton SB EMBO J. 2007 Jul 26 13 3144-56
- BMRP is a Bcl-2 binding protein that induces apoptosis.
- Chintharlapalli SR, Jasti M, Malladi S, Parsa KV, Ballestero RP, González-García M J. Cell. Biochem. 2005 Feb 94 3 611-26
Apoptosis. In Comprehensive Toxicology
Srinivas Malladi, Madhavi Challa-Malladi, and Shawn Bratton (2010). Elsevier, Elsevier
Mouse Models to Study Natural Killer Cell-Mediated Immunosurveillance and Metastatic Latency.. In Cancer Immunosurveillance
Nair VR, Malladi S (2019). Springer Protocols,
Honors & Awards
- Cancer Prevention Research Institute of Texas
Scholar Award (2017-2020)
- American Cancer Society
Research Fellow (2012-2015)
- University of Texas - Austin Graduate Student Fellowship
- American Association for Cancer Research (2010)