Srinivas Malladi, Ph.D.
Assistant Professor

Srinivas obtained his Ph.D. from The University of Texas at Austin and then joined Memorial Sloan Kettering Cancer Center as an American Cancer Society Fellow with Dr. Joan Massague.

Dr. Malladi’s lab in the Department of Pathology is focused on understanding how disseminated cancer cells survive and give rise to overt metastasis at a cellular and molecular level using a multidisciplinary and integrative approach.

• Cancer Invasion and Metastasis
• Metastatic Stem Cells
• Tumor Biology and Microenvironment

Featured Publications

Mouse Models to Study Natural Killer Cell-Mediated Immunosurveillance and Metastatic Latency.

Nair VR, Malladi S Methods Mol. Biol. 2019 1884 141-150

Metastatic Latency, a Veiled Threat.

Kim K, Marquez-Palencia M, Malladi S, Front Immunol 2019 10 1836

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.

Er EE, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, Griscom B, Rosenblum M, Boire A, Brogi E, Giancotti FG, Schachner M, Malladi S, Massagué J Nat. Cell Biol. 2018 Aug 20 8 966-978

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.

Malladi S, Macalinao DG, Jin X, He L, Basnet H, Zou Y, de Stanchina E, Massagué J Cell 2016 Mar 165 1 45-60

Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.

Zhang XH, Jin X, Malladi S, Zou Y, Wen YH, Brogi E, Smid M, Foekens JA, Massagué J Cell 2013 Aug 154 5 1060-73

A CXCL1 paracrine network links cancer chemoresistance and metastasis.

Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris PG, Manova-Todorova K, Leversha M, Hogg N, Seshan VE, Norton L, Brogi E, Massagué J Cell 2012 Jul 150 1 165-78

The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer.

Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB EMBO J. 2009 Jul 28 13 1916-25

The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities.

Wu CC, Lee S, Malladi S, Chen MD, Mastrandrea NJ, Zhang Z, Bratton SB Nat Commun 2016 Nov 7 13565

The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation.

Fisher AA, Labenski MT, Malladi S, Chapman JD, Bratton SB, Monks TJ, Lau SS Toxicol. Sci. 2011 Jul 122 1 64-72

Deletion mutational analysis of BMRP, a pro-apoptotic protein that binds to Bcl-2.

Malladi S, Parsa KV, Bhupathi D, Rodríguez-González MA, Conde JA, Anumula P, Romo HE, Claunch CJ, Ballestero RP, González-García M Mol. Cell. Biochem. 2011 May 351 1-2 217-32

 Featured Books

Apoptosis. In Comprehensive Toxicology

Srinivas Malladi, Madhavi Challa-Malladi, and Shawn Bratton (2010). Elsevier, Elsevier

Mouse Models to Study Natural Killer Cell-Mediated Immunosurveillance and Metastatic Latency.. In Cancer Immunosurveillance

Nair VR, Malladi S (2019). Springer Protocols,

• Cancer Prevention Research Institute of Texas
  Scholar Award (2017-2020)
• American Cancer Society
  Research Fellow (2012-2015)
• University of Texas - Austin Graduate Student Fellowship
  (2010)

• American Association for Cancer Research (2010)