Srinivas Malladi, Ph.D.

Srinivas obtained his Ph.D. from The University of Texas at Austin and then joined Memorial Sloan Kettering Cancer Center as an American Cancer Society Fellow with Dr. Joan Massague.

Dr. Malladi’s lab in the Department of Pathology is focused on understanding how disseminated cancer cells survive and give rise to overt metastasis at a cellular and molecular level using a multidisciplinary and integrative approach.

• Cancer Cell Biology
• Host Tumor Interactions
• Metastatic Latency and Recurrence
• Tumor Heterogeneity and Metastasis
• Tumor Metabolism

Featured Publications

AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer.

Marquez-Palencia M, Reza Herrera L, Parida PK, Ghosh S, Kim K, Das NM, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Diegeler S, Aguilera TA, Peng Y, Lewis CM, Arteaga CL, Hanker AB, Whitehurst AW, Lorens JB, Brekken RA, Davis AJ, Malladi S, Cancer Res 2024 Jan

Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases.

Parida PK, Marquez-Palencia M, Ghosh S, Khandelwal N, Kim K, Nair V, Liu XZ, Vu HS, Zacharias LG, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, McDonald JG, Lemoff A, Peng Y, Lewis C, Vale G, Halberg N, Arteaga CL, Hanker AB, DeBerardinis RJ, Malladi S, Nat Cancer 2023 Jun 4 6 893-907

Cell Competition Shapes Metastatic Latency and Relapse.

Kim K, Huang H, Parida PK, He L, Marquez-Palencia M, Reese TC, Kapur P, Brugarolas J, Brekken RA, Malladi S, Cancer Discov 2022 Sep

Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness.

Parida PK, Marquez-Palencia M, Nair V, Kaushik AK, Kim K, Sudderth J, Quesada-Diaz E, Cajigas A, Vemireddy V, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Huffman K, Sahoo S, Alluri P, Lewis C, Peng Y, Bachoo RM, Arteaga CL, Hanker AB, DeBerardinis RJ, Malladi S, Cell Metab 2022 Jan 34 1 90-105.e7

Determinants of renal cell carcinoma invasion and metastatic competence.

Kim K, Zhou Q, Christie A, Stevens C, Ma Y, Onabolu O, Chintalapati S, Mckenzie T, Tcheuyap VT, Woolford L, Zhang H, Singla N, Parida PK, Marquez-Palencia M, Pedrosa I, Margulis V, Sagalowsky A, Xie Z, Wang T, Durinck S, Modrusan Z, Seshagiri S, Kapur P, Brugarolas J, Malladi S, Nat Commun 2021 10 12 1 5760

Mouse Models to Study Natural Killer Cell-Mediated Immunosurveillance and Metastatic Latency.

Nair VR, Malladi S Methods Mol. Biol. 2019 1884 141-150

Metastatic Latency, a Veiled Threat.

Kim K, Marquez-Palencia M, Malladi S, Front Immunol 2019 10 1836

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.

Er EE, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, Griscom B, Rosenblum M, Boire A, Brogi E, Giancotti FG, Schachner M, Malladi S, Massagué J Nat. Cell Biol. 2018 Aug 20 8 966-978

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.

Malladi S, Macalinao DG, Jin X, He L, Basnet H, Zou Y, de Stanchina E, Massagué J Cell 2016 Mar 165 1 45-60

Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.

Zhang XH, Jin X, Malladi S, Zou Y, Wen YH, Brogi E, Smid M, Foekens JA, Massagué J Cell 2013 Aug 154 5 1060-73

 Featured Books

Apoptosis. In Comprehensive Toxicology

Srinivas Malladi, Madhavi Challa-Malladi, and Shawn Bratton (2010). Elsevier, Elsevier

Mouse Models to Study Natural Killer Cell-Mediated Immunosurveillance and Metastatic Latency.. In Cancer Immunosurveillance

Nair VR, Malladi S (2019). Springer Protocols,

• Cancer Prevention Research Institute of Texas
  Scholar Award (2017-2020)
• American Cancer Society
  Research Fellow (2012-2015)
• University of Texas - Austin Graduate Student Fellowship
  (2010)

• American Association for Cancer Research (2010)