Brendan Kelley, M.D., is Associate Professor and Clinical Vice-Chair of the Department of Neurology at UT Southwestern Medical Center. He specializes in evaluation and study of neurological causes of impairment in memory and cognition.

A native of Ohio, Dr. Kelley earned his medical degree at The Ohio State University and the Executive MBA Program at The Ohio State University’s Fisher College of Business. He also earned a master’s degree in Physics at Cornell University. Dr. Kelley completed a residency in neurology at Cleveland Clinic and then received advanced fellowship training in Behavioral Neurology and Multiple Sclerosis at Mayo Clinic.

Dr. Kelley returned to The Ohio State University in 2014, where his clinical work and research focused on Alzheimer’s disease and Lewy body dementia. While there, he established a fellowship program in Behavioral Neurology and Neuropsychiatry. Prior to that, he served as the Bob and Sandy Heimann Chair for Alzheimer’s Disease Research and Education in the University of Cincinnati Department of Neurology from 2008 to 2013.

Certified by the American Board of Psychiatry and Neurology and in Behavioral Neurology by the Unified Council of Neurological Subspecialties, Dr. Kelley proudly joined the UT Southwestern faculty in 2017 as Associate Professor and Clinical Vice-Chair of Neurology.

Dr. Kelley’s research activity focuses on the clinical translation of novel techniques to study emerging techniques to better identify changes in the brain and spinal fluid related to Alzheimer’s disease and other dementias. He collaborates with investigators in many of the research labs at UT Southwestern that conduct basic scientific investigations aimed to better understand the biological processes that cause neurodegeneration, and to improve our ability to detect these changes before irreversible cognitive impairments have occurred. He also participates in clinical research trials conducted throughout the United States which are aimed to test new compounds as potential treatments for dementia.

Dr. Kelley has authored numerous peer-reviewed scientific articles and book chapters related to Alzheimer’s disease and other dementias. His commitment to the field extends to future, and he proudly directs the UT Southwestern Behavioral Neurology and Neuropsychiatry fellowship program. His enthusiasm for the field and dedication to the role of educator contributes meaningfully to the education of residents, graduate students and fellows, ensuring the future progress of treating these challenging diseases.

Dr. Kelley is highly committed to the care of patients having disorders of memory and cognition. He regularly receives accolades for his outstanding patient satisfaction and collegiality.


Medical School
The Ohio State University College of Medicine (2002)
Cleveland Clinic Foundation (2003), Internal Medicine
Cleveland Clinic Foundation (2006), Neurology
Mayo Clinic College of Medicine and Science (2007), Behavioral Neurology
Mayo Clinic College of Science and Medicine (2008), Multiple Sclerosis

Research Interest

  • Alzheimer's Disease
  • Atypical Dementias
  • Frontotemporal Dementia
  • Lewy Body Dementia
  • Mild Cognitive Impairment
  • Young-Onset Dementia


Featured Publications LegendFeatured Publications

Dopamine agonists and pathologic behaviors.
Kelley BJ, Duker AP, Chiu P Parkinsons Dis 2012 2012 603631
Vascular risk factors and cognitive impairment in a stroke-free cohort.
Unverzagt FW, McClure LA, Wadley VG, Jenny NS, Go RC, Cushman M, Kissela BM, Kelley BJ, Kennedy R, Moy CS, Howard V, Howard G Neurology 2011 Nov 77 19 1729-36
Compressive myelopathy mimicking transverse myelitis.
Kelley BJ, Erickson BJ, Weinshenker BG Neurologist 2010 Mar 16 2 120-2
Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin.
Kelley BJ, Haidar W, Boeve BF, Baker M, Shiung M, Knopman DS, Rademakers R, Hutton M, Adamson J, Kuntz KM, Dickson DW, Parisi JE, Smith GE, Petersen RC Arch. Neurol. 2010 Feb 67 2 171-7
Seizures in patients with multiple sclerosis: epidemiology, pathophysiology and management.
Kelley BJ, Rodriguez M CNS Drugs 2009 Oct 23 10 805-15
Prominent phenotypic variability associated with mutations in Progranulin.
Kelley BJ, Haidar W, Boeve BF, Baker M, Graff-Radford NR, Krefft T, Frank AR, Jack CR, Shiung M, Knopman DS, Josephs KA, Parashos SA, Rademakers R, Hutton M, Pickering-Brown S, Adamson J, Kuntz KM, Dickson DW, Parisi JE, Smith GE, Ivnik RJ, Petersen RC Neurobiol. Aging 2009 May 30 5 739-51
Rapidly progressive young-onset dementia.
Kelley BJ, Boeve BF, Josephs KA Cogn Behav Neurol 2009 Mar 22 1 22-7
Cognitive and noncognitive neurological features of young-onset dementia.
Kelley BJ, Boeve BF, Josephs KA Dement Geriatr Cogn Disord 2009 27 6 564-71
Young-onset dementia: demographic and etiologic characteristics of 235 patients.
Kelley BJ, Boeve BF, Josephs KA Arch. Neurol. 2008 Nov 65 11 1502-8
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.
Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NA, Xu YF, Stewart H, Kelley BJ, Kuntz K, Crook RJ, Sreedharan J, Vance C, Sorenson E, Lippa C, Bigio EH, Geschwind DH, Knopman DS, Mitsumoto H, Petersen RC, Cashman NR, Hutton M, Shaw CE, Boylan KB, Boeve B, Graff-Radford NR, Wszolek ZK, Caselli RJ, Dickson DW, Mackenzie IR, Petrucelli L, Rademakers R PLoS Genet. 2008 Sep 4 9 e1000193


Featured Books Legend Featured Books

Honors & Awards

  • UT Southwestern APP Champion of the Year
  • Buckeye Pride Award for Patient Satisfaction
  • Columbus Monthly Top Doctors
  • Cincinnati Magazine Top Doctors
  • Bob and Sandy Heimann Chair for Alzheimer¬ís Disease Research and Education, University of Cincinnati Department of Neurology
  • AAN Award for Excellence in Clinical Neurology
  • The Ohio State University Neurology Department Award for Outstanding Performance
  • Excellence in Teaching Award, The Ohio State University Department of Physics
  • J. D. and C. D. Smith award, The Ohio State University Department of Physics
  • Summa Cum Laude, The Ohio State University
  • Outstanding Scholar in the College of Humanities, The Ohio State University
  • Distinguished Scholar Award, The Ohio State University
  • Dobro Slovo (National Slavic Studies Honor Society)
  • Phi Beta Kappa, The Ohio State University

Professional Associations/Affiliations

  • Fellow - American Neurological Association (2013)
  • Fellow - American Academy of Neurology (2000)