Brendan Kelley, M.D., is Associate Professor and Clinical Vice-Chair of the Department of Neurology at UT Southwestern Medical Center. He specializes in evaluation and study of neurological causes of impairment in memory and cognition.

A native of Ohio, Dr. Kelley earned his medical degree at The Ohio State University and the Executive MBA Program at The Ohio State University’s Fisher College of Business. He also earned a master’s degree in Physics at Cornell University. Dr. Kelley completed a residency in neurology at Cleveland Clinic and then received advanced fellowship training in Behavioral Neurology and Multiple Sclerosis at Mayo Clinic.

Dr. Kelley returned to The Ohio State University in 2014, where his clinical work and research focused on Alzheimer’s disease and Lewy body dementia. While there, he established a fellowship program in Behavioral Neurology and Neuropsychiatry. Prior to that, he served as the Bob and Sandy Heimann Chair for Alzheimer’s Disease Research and Education in the University of Cincinnati Department of Neurology from 2008 to 2013.

Certified by the American Board of Psychiatry and Neurology and in Behavioral Neurology by the Unified Council of Neurological Subspecialties, Dr. Kelley proudly joined the UT Southwestern faculty in 2017 as Associate Professor and Clinical Vice-Chair of Neurology.

Dr. Kelley’s research activity focuses on the clinical translation of novel techniques to study emerging techniques to better identify changes in the brain and spinal fluid related to Alzheimer’s disease and other dementias. He collaborates with investigators in many of the research labs at UT Southwestern that conduct basic scientific investigations aimed to better understand the biological processes that cause neurodegeneration, and to improve our ability to detect these changes before irreversible cognitive impairments have occurred. He also participates in clinical research trials conducted throughout the United States which are aimed to test new compounds as potential treatments for dementia.

Dr. Kelley has authored numerous peer-reviewed scientific articles and book chapters related to Alzheimer’s disease and other dementias. His commitment to the field extends to future, and he proudly directs the UT Southwestern Behavioral Neurology and Neuropsychiatry fellowship program. His enthusiasm for the field and dedication to the role of educator contributes meaningfully to the education of residents, graduate students and fellows, ensuring the future progress of treating these challenging diseases.

Dr. Kelley is highly committed to the care of patients having disorders of memory and cognition. He regularly receives accolades for his outstanding patient satisfaction and collegiality.


Medical School
The Ohio State University College of Medicine (2002)
Cleveland Clinic Foundation (2003), Internal Medicine
Cleveland Clinic Foundation (2006), Neurology
Mayo Clinic College of Medicine and Science (2007), Behavioral Neurology
Mayo Clinic College of Science and Medicine (2008), Multiple Sclerosis

Research Interest

  • Alzheimer's Disease
  • Atypical Dementias
  • Frontotemporal Dementia
  • Lewy Body Dementia
  • Mild Cognitive Impairment
  • Young-Onset Dementia


Featured Publications LegendFeatured Publications

Bilingual problem-solving training for caregivers of adults with dementia: A randomized, factorial-design protocol for the CaDeS trial.
Juengst S, Supnet C, Kew CLN, Silva V, Vega M, Han G, Kelley B, Smith ML, Maestre G, Contemp Clin Trials 2021 Jul 108 106506
Dramatic Benefits from Standard Work Implementation
Kelley BJ, Bellamy B, Haley R J Medical Practice Management 2018 33 6 378-382
Chronic Use of Aspirin and Total White Matter Lesion Volume: Results from the Women's Health Initiative Memory Study of Magnetic Resonance Imaging Study.
Holcombe A, Ammann E, Espeland MA, Kelley BJ, Manson JE, Wallace R, Robinson J J Stroke Cerebrovasc Dis 2017 May
Treatment of Mild Cognitive Impairment.
Kelley BJ Curr Treat Options Neurol 2015 Sep 17 9 372
Regular aspirin use does not reduce risk of cognitive decline.
Kelley BJ, McClure LA, Unverzagt FW, Kissela B, Kleindorfer D, Howard G, Wadley VG J Am Geriatr Soc 2015 Feb 63 2 390-2
Vascular Cognitive Impairment - Part 1
Zha AM, Kelley BJ Practical Neurology 2015 January/February
Vascular Cognitive Impairment ? Part 2
Zha AM, Kelley BJ Practical Neurology 2015 March
Performance of the NINDS-CSN 5-minute protocol in a national population-based sample.
Kennedy RE, Wadley VG, McClure LA, Letter AJ, Unverzagt FW, Crowe M, Nyenhius D, Kelley BJ, Kana B, Marceaux J, Kurella Tamura M, Howard V, Howard G J Int Neuropsychol Soc 2014 Sep 20 8 856-67
Cognitive effects of statin medications.
Kelley BJ, Glasser S CNS Drugs 2014 May 28 5 411-9
C9ORF72 repeat expansions in cases with previously identified pathogenic mutations.
van Blitterswijk M, Baker MC, DeJesus-Hernandez M, Ghidoni R, Benussi L, Finger E, Hsiung GY, Kelley BJ, Murray ME, Rutherford NJ, Brown PE, Ravenscroft T, Mullen B, Ash PE, Bieniek KF, Hatanpaa KJ, Karydas A, Wood EM, Coppola G, Bigio EH, Lippa C, Strong MJ, Beach TG, Knopman DS, Huey ED, Mesulam M, Bird T, White CL, Kertesz A, Geschwind DH, Van Deerlin VM, Petersen RC, Binetti G, Miller BL, Petrucelli L, Wszolek ZK, Boylan KB, Graff-Radford NR, Mackenzie IR, Boeve BF, Dickson DW, Rademakers R Neurology 2013 Oct 81 15 1332-41


Featured Books Legend Featured Books

Honors & Awards

  • UT Southwestern APP Champion of the Year
  • Buckeye Pride Award for Patient Satisfaction
  • Columbus Monthly Top Doctors
  • Cincinnati Magazine Top Doctors
  • Bob and Sandy Heimann Chair for Alzheimer¬ís Disease Research and Education, University of Cincinnati Department of Neurology
  • AAN Award for Excellence in Clinical Neurology
  • The Ohio State University Neurology Department Award for Outstanding Performance
  • Excellence in Teaching Award, The Ohio State University Department of Physics
  • J. D. and C. D. Smith award, The Ohio State University Department of Physics
  • Summa Cum Laude, The Ohio State University
  • Outstanding Scholar in the College of Humanities, The Ohio State University
  • Distinguished Scholar Award, The Ohio State University
  • Dobro Slovo (National Slavic Studies Honor Society)
  • Phi Beta Kappa, The Ohio State University

Professional Associations/Affiliations

  • Fellow - American Academy of Neurology (2000)
  • Fellow - American Neurological Association (2013)