Dr. Thiele joined the Department of Internal Medicine in 1983, and the Graduate Program in Immunology in the Graduate School of Biomedical Sciences in 1986. He served as Chief of Hepatology from 1998-2005, Interim Chief of the Division of Digestive and Liver Diseases from 2002-2005,Vice Chair for Financial Affairs, Department of Internal Medicine from 2005-2010 and as Interim Chair, Department of Internal Medicine, 2009-2010 before assuming his current position as a Senior Associate Dean. Dr. Thiele has broad interests in clinical hepatology, with special interests in acute viral hepatitis, autoimmune hepatitis and acute hepatitis of unknown etiology. Research conducted in Dr. Thiele’s laboratory focuses on delineating mechanisms of cytotoxic lymphocyte activation, differentiation and effector function, and exploring the role of these immune effector mechanisms in clearance of viral infections from the liver.


Medical School
Baylor College of Medicine (1977)
Duke University School of Medicine (1980), Internal Medicine
University of Texas Southwestern Medical School (1983), Gastroenterology & Liver Diseases

Research Interest

  • Antiviral immune responses
  • Cytotoxic lymphocyte function
  • Transplantation immunology


Featured Publications LegendFeatured Publications

The role of serpinB9 / serine protease inhibitor 6 in preventing granzyme B dependent hepatotoxicity
Stout-Delgado HW, Y Getachew, TE Rogers, BC Miller and DL Thiele Hepatology 2007 45 In Press
Intrahepatic Lymphocyte Expression of Dipeptidyl Peptidase I Processed Granzyme B and Perforin Induces Hepatocyte Expression of Serine Proteinase Inhibitor 6 (Serpinb9/SPI-6).
74. Stout-Delgado HW, Y Getachew, BC Miller and DL Thiele J. Immunol. 2007 179 6561-6567
Anti-viral cytokines induce hepatic expression of the granzyme B inhibitors proteinase inhibitor 9 and serine proteinase inhibitor 6
Barrie MB, HW Stout, MS Abougergi, BC Miller and DL Thiele J Immunol 2004 172 6453-6459
Fas and TNFR1 but not cytolytic granule dependent mechanisms mediate clearance of liver adenovirus infection
Abougergi MC, SJ Gidner, DK Spady, BC Miller and DL Thiele Hepatology 2004 41 97-102
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo
Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB and Thiele DL Proc Natl Acad Sci U S A 2003 100 6221-6226

Honors & Awards

  • American Association of Physicians
  • Teacher of the Year, UT Southwestern Gastroenterology Training Program
  • American Society for Clinical Investigation
  • Best Doctors in America
  • Teacher of the Year, UT Southwestern Gastroenterology Training Program

Professional Associations/Affiliations

  • American Association for Immunologists
  • American Association for the Study of Liver Diseases
  • American Gastroenterological Association