Dwain Thiele, M.D. Professor Emeritus School Medical School Department Office of the Provost | Internal Medicine Graduate Programs Immunology Biography Dwain L. Thiele, M.D., FAASLD, is Professor Emeritus of Internal Medicine. He joined the UT Southwestern faculty in 1983. Dr. Thiele served in various roles including Vice Provost and Senior Assoicate Dean for Faculty Affairs and Initiatives; Senior Assoicate Dean for Strategic Development; Interim Chair of Internal Medicine; Interim Executive Vice President for Academic Affairs, Provost, and Dean of UT Southwestern Medical School; and Interim Chair of the Department of Ophthalmology. He recieved his medical degree from Baylor College of Medicine in Houston and completed his residency in Internal Medicine at Duke Univeristy School of Medicine, followed by fellowship training in Gastroenterology and Hepatology at UT Southwestern. His research has focused on delineating mechanisms of cytotoxic lymphocyte activation, differentiation, and effector function. Education Undergraduate Rice University (1974) Medical School Baylor College of Medicine (1977) Research Interest Antiviral immune responses Cytotoxic lymphocyte function Transplantation immunology Publications Featured Publications A selective inhibitor of dipeptidyl peptidase I impairs generation of CD8(+) T cell cytotoxic effector function Thiele DL, McGuire MJ and Lipsky PE J. Immunol. 1997 158 5200-5210 Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I McGuire MJ, Lipsky PE and Thiele DL J. Biol. Chem. 1993 268 2458-2467 The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I mediated conversion to membranolytic products Thiele DL and Lipsky PE J. Exp. Med. 1990 172 183-194 Intestinal graft versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes Thiele DL, Eigenbrodt ML, Bryde SE, Eigenbrodt EH and Lipsky PE J. Clin. Invest. 1989 84 1947-1956 Regulation of cellular function by products of lysosomal enzyme activity: Elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes Thiele DL and Lipsky PE Proc. Natl. Acad. Sci. USA 1985 82 2468-2472 The role of serpinB9 / serine protease inhibitor 6 in preventing granzyme B dependent hepatotoxicity Stout-Delgado HW, Y Getachew, TE Rogers, BC Miller and DL Thiele Hepatology 2007 45 In Press Intrahepatic Lymphocyte Expression of Dipeptidyl Peptidase I Processed Granzyme B and Perforin Induces Hepatocyte Expression of Serine Proteinase Inhibitor 6 (Serpinb9/SPI-6). 74. Stout-Delgado HW, Y Getachew, BC Miller and DL Thiele J. Immunol. 2007 179 6561-6567 Anti-viral cytokines induce hepatic expression of the granzyme B inhibitors proteinase inhibitor 9 and serine proteinase inhibitor 6 Barrie MB, HW Stout, MS Abougergi, BC Miller and DL Thiele J Immunol 2004 172 6453-6459 Fas and TNFR1 but not cytolytic granule dependent mechanisms mediate clearance of liver adenovirus infection Abougergi MC, SJ Gidner, DK Spady, BC Miller and DL Thiele Hepatology 2004 41 97-102 Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB and Thiele DL Proc Natl Acad Sci U S A 2003 100 6221-6226 Results 1-10 of 10 1 Honors & Awards American Association of Physicians (2004) Teacher of the Year, UT Southwestern Gastroenterology Training Program (2000) American Society for Clinical Investigation (1997) Best Doctors in America (1996) Teacher of the Year, UT Southwestern Gastroenterology Training Program (1994) Professional Associations/Affiliations American Association for Immunologists American Association for the Study of Liver Diseases American Gastroenterological Association
