Dwain Thiele, M.D.

Dwain L. Thiele, M.D., FAASLD, is currently serving as the Vice Provost and Senior Associate Dean for Faculty Affairs and Initiatives, working in this capacity to expand opportunities for the growth and development of the faculty and for sustaining and further developing the Medical Center's academic enterprise.  A Professor of Internal Medicine, Dr. Thiele joined the UT Southwestern faculty in 1983 and has served as Vice Chair for Financial Affairs and as Interim Chair of the Department of Internal Medicine.  He also previously served as Chief of Hepatology and as Interim Chief of the Division of Digestive and Liver Diseases.  He received his medical degree from Baylor College of Medicine in Houston and completed his residency in Internal Medicine at Duke University School of Medicine, followed by fellowship training in Gastroenterology and Hepatology at UT Southwestern.  His research has focused on delineating mechanisms of cytotoxic lymphocyte activation, differentiation, and effector function.

Medical School

Baylor College of Medicine (1977)

Residency

Duke University School of Medicine (1980), Internal Medicine

Fellowship

UT Southwestern Medical School (1983), Gastroenterology & Liver Diseases

• Antiviral immune responses
• Cytotoxic lymphocyte function
• Transplantation immunology

Featured Publications

A selective inhibitor of dipeptidyl peptidase I impairs generation of CD8(+) T cell cytotoxic effector function

Thiele DL, McGuire MJ and Lipsky PE J. Immunol. 1997 158 5200-5210

Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I

McGuire MJ, Lipsky PE and Thiele DL J. Biol. Chem. 1993 268 2458-2467

The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I mediated conversion to membranolytic products

Thiele DL and Lipsky PE J. Exp. Med. 1990 172 183-194

Intestinal graft versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes

Thiele DL, Eigenbrodt ML, Bryde SE, Eigenbrodt EH and Lipsky PE J. Clin. Invest. 1989 84 1947-1956

Regulation of cellular function by products of lysosomal enzyme activity: Elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes

Thiele DL and Lipsky PE Proc. Natl. Acad. Sci. USA 1985 82 2468-2472

The role of serpinB9 / serine protease inhibitor 6 in preventing granzyme B dependent hepatotoxicity

Stout-Delgado HW, Y Getachew, TE Rogers, BC Miller and DL Thiele Hepatology 2007 45 In Press

Intrahepatic Lymphocyte Expression of Dipeptidyl Peptidase I Processed Granzyme B and Perforin Induces Hepatocyte Expression of Serine Proteinase Inhibitor 6 (Serpinb9/SPI-6).

74. Stout-Delgado HW, Y Getachew, BC Miller and DL Thiele J. Immunol. 2007 179 6561-6567

Anti-viral cytokines induce hepatic expression of the granzyme B inhibitors proteinase inhibitor 9 and serine proteinase inhibitor 6

Barrie MB, HW Stout, MS Abougergi, BC Miller and DL Thiele J Immunol 2004 172 6453-6459

Fas and TNFR1 but not cytolytic granule dependent mechanisms mediate clearance of liver adenovirus infection

Abougergi MC, SJ Gidner, DK Spady, BC Miller and DL Thiele Hepatology 2004 41 97-102

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB and Thiele DL Proc Natl Acad Sci U S A 2003 100 6221-6226

• American Association of Physicians
  (2004)
• Teacher of the Year, UT Southwestern Gastroenterology Training Program
  (2000)
• American Society for Clinical Investigation
  (1997)
• Best Doctors in America
  (1996)
• Teacher of the Year, UT Southwestern Gastroenterology Training Program
  (1994)

• American Association for Immunologists
• American Association for the Study of Liver Diseases
• American Gastroenterological Association