Dwain L. Thiele, M.D., FAASLD, is currently serving as the Vice Provost and Senior Associate Dean for Faculty Affairs and Initiatives, working in this capacity to expand opportunities for the growth and development of the faculty and for sustaining and further developing the Medical Center's academic enterprise.  A Professor of Internal Medicine, Dr. Thiele joined the UT Southwestern faculty in 1983 and has served as Vice Chair for Financial Affairs and as Interim Chair of the Department of Internal Medicine.  He also previously served as Chief of Hepatology and as Interim Chief of the Division of Digestive and Liver Diseases.  He received his medical degree from Baylor College of Medicine in Houston and completed his residency in Internal Medicine at Duke University School of Medicine, followed by fellowship training in Gastroenterology and Hepatology at UT Southwestern.  His research has focused on delineating mechanisms of cytotoxic lymphocyte activation, differentiation, and effector function.


Medical School
Baylor College of Medicine (1977)
Duke University School of Medicine (1980), Internal Medicine
UT Southwestern Medical School (1983), Gastroenterology & Liver Diseases

Research Interest

  • Antiviral immune responses
  • Cytotoxic lymphocyte function
  • Transplantation immunology


Featured Publications LegendFeatured Publications

The role of serpinB9 / serine protease inhibitor 6 in preventing granzyme B dependent hepatotoxicity
Stout-Delgado HW, Y Getachew, TE Rogers, BC Miller and DL Thiele Hepatology 2007 45 In Press
Intrahepatic Lymphocyte Expression of Dipeptidyl Peptidase I Processed Granzyme B and Perforin Induces Hepatocyte Expression of Serine Proteinase Inhibitor 6 (Serpinb9/SPI-6).
74. Stout-Delgado HW, Y Getachew, BC Miller and DL Thiele J. Immunol. 2007 179 6561-6567
Anti-viral cytokines induce hepatic expression of the granzyme B inhibitors proteinase inhibitor 9 and serine proteinase inhibitor 6
Barrie MB, HW Stout, MS Abougergi, BC Miller and DL Thiele J Immunol 2004 172 6453-6459
Fas and TNFR1 but not cytolytic granule dependent mechanisms mediate clearance of liver adenovirus infection
Abougergi MC, SJ Gidner, DK Spady, BC Miller and DL Thiele Hepatology 2004 41 97-102
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo
Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB and Thiele DL Proc Natl Acad Sci U S A 2003 100 6221-6226

Honors & Awards

  • American Association of Physicians
  • Teacher of the Year, UT Southwestern Gastroenterology Training Program
  • American Society for Clinical Investigation
  • Best Doctors in America
  • Teacher of the Year, UT Southwestern Gastroenterology Training Program

Professional Associations/Affiliations

  • American Association for Immunologists
  • American Association for the Study of Liver Diseases
  • American Gastroenterological Association