Ngoc Uyen Nhi Nguyen, Ph.D.

• Cardiac and Skeletal Muscle Regeneration
• Heart Failure
• Muscular Dystrophy
• Sarcopenia
• Skeletal Muscle Differentiation

 Featured Publications

A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes.

Nguyen NUN, Canseco DC, Xiao F, Nakada Y, Li S, Lam NT, Muralidhar SA, Savla JJ, Hill JA, Le V, Zidan KA, El-Feky HW, Wang Z, Ahmed MS, Hubbi ME, Menendez-Montes I, Moon J, Ali SR, Le V, Villalobos E, Mohamed MS, Elhelaly WM, Thet S, Anene-Nzelu CG, Tan WLW, Foo RS, Meng X, Kanchwala M, Xing C, Roy J, Cyert MS, Rothermel BA, Sadek HA, Nature 2020 06 582 7811 271-276

Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.

Ahmed MS, Wang P, Nguyen NUN, Nakada Y, Menendez-Montes I, Ismail M, Bachoo R, Henkemeyer M, Sadek HA, Kandil ES, Proc Natl Acad Sci U S A 2021 Mar 118 10

Mechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Severe Mitral Regurgitation.

Li S, Nguyen NUN, Xiao F, Menendez-Montes I, Nakada Y, Tan WLW, Anene-Nzelu CG, Foo RS, Thet S, Cardoso AC, Wang P, Elhelaly WM, Lam NT, Pereira AHM, Hill JA, Sadek HA, Circulation 2020 Jun 141 22 1787-1799

Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression.

Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, Menendez-Montes I, Ensley EL, Petric UB, Sharma G, Sherry AD, Malloy CR, Khemtong C, Kinter MT, Tan WLW, Anene-Nzelu CG, Foo RS, Nguyen NUN, Li S, Ahmed MS, Elhelaly WM, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert KM, Mitsche MA, McDonald JG, Hill JA, Huang L, Shaul PW, Szweda LI, Sadek HA, Nat Metab 2020 Feb 2 2 167-178

Fibroblast Primary Cilia are Required for Cardiac Fibrosis.

Villalobos E, Criollo A, Schiattarella GG, Altamirano F, French KM, May HI, Jiang N, Nguyen NUN, Romero D, Roa JC, García L, Diaz-Araya G, Morselli E, Ferdous A, Conway SJ, Sadek HA, Gillette TG, Lavandero S, Hill JA, Circulation 2019 Mar

DNA Damage Response Mediates Pressure Overload-Induced Cardiomyocyte Hypertrophy.

Nakada Y, Nhi Nguyen NU, Xiao F, Savla JJ, Lam NT, Abdisalaam S, Bhattacharya S, Mukherjee S, Asaithamby A, Gillette TG, Hill JA, Sadek HA Circulation 2019 Feb 139 9 1237-1239

Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.

Rotter D, Peiris H, Grinsfelder DB, Martin AM, Burchfield J, Parra V, Hull C, Morales CR, Jessup CF, Matusica D, Parks BW, Lusis AJ, Nguyen NUN, Oh M, Iyoke I, Jakkampudi T, McMillan DR, Sadek HA, Watt MJ, Gupta RK, Pritchard MA, Keating DJ, Rothermel BA EMBO Rep. 2018 Dec 19 12

Dual roles of palladin protein in in vitro myogenesis: inhibition of early induction but promotion of myotube maturation.

Nguyen NU, Wang HV, PLoS One 2015 10 4 e0124762

Actin-associated protein palladin is required for migration behavior and differentiation potential of C2C12 myoblast cells.

Nguyen NU, Liang VR, Wang HV, Biochem Biophys Res Commun 2014 Sep 452 3 728-33

 Featured Books

Chapter 8 - Autophagy in germ cells, stem cells, and induced pluripotent stem cells. In Autophagy in Health and Disease

Moydul Islam, Ngoc Uyen Nhi Nguyen, Abhinav Diwan and Beverly A. Rothermel (2022). Elsevier

• American Heart Association
  Career Development Award (2021-2024)
• The Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center
  Trainee Fellowship (2020-2021)
• American Heart Association
  Postdoctoral Fellowship (2018-2020)
• The Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center
  Trainee Fellowship (2017-2018)
• The Biology Society of China 38th Conference-Biodiversity Under Threat Symposium, Taiwan
  Best Poster Award (2013)

• American Heart Association (2017)