Dr. Huocong Huang received his medical degree from Sun Yat-sen University and his Ph.D. in Biochemistry and Molecular Biology from University of Nebraska Medical Center. His graduate research was mentored by Dr. Keith R. Johnson, focusing on the signaling transduction and protein interaction of collagen-induced cell plasticity. He then joined Dr. Rolf Brekken’s laboratory at UT Southwestern Medical Center for postdoctoral training. His postdoctoral research studied the function of cancer-associated fibroblasts and extracellular matrix in pancreatic ductal adenocarcinoma. He also examined the therapeutic potential of these stromal targets using animal models. Dr. Huang’s current research is focused on understanding the origin, immune-regulating function and signaling of fibroblast in physiological or pathological conditions including cancer, immune-related diseases and aging.  


Graduate School
Uni of Nebraska-Med Ctr (2016), Philosophy

Research Interest

  • Cancer-associated Fibroblast
  • Cell Biology
  • Fibrosis
  • Mesothelial Cell
  • Signal Transduction
  • Tumor Microenvironment


Featured Publications LegendFeatured Publications

Tumor cell-intrinsic epigenetic SETpoint of cancer-associated fibroblasts.
Chen X, Huang H, Cancer Cell 2024 Apr
FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells.
Zhu Z, Lou G, Teng XL, Wang H, Luo Y, Shi W, Yihunie K, Hao S, DeGolier K, Liao C, Huang H, Zhang Q, Fry T, Wang T, Yao C, Wu T, Nat Immunol 2023 Nov
TWIST2-mediated chromatin remodeling promotes fusion-negative rhabdomyosarcoma.
Shah AM, Guo L, Morales MG, Jaichander P, Chen K, Huang H, Cano Hernandez K, Xu L, Bassel-Duby R, Olson EN, Liu N, Sci Adv 2023 Apr 9 17 eade8184
Targeting TNF-a producing macrophages activate antitumor immunity in pancreatic cancer through IL33 signaling.
Dixit A, Sarver AL, Zettervall J, Huang H, Zheng K, Brekken RA, Provenzano P, JCI Insight 2022 Oct
Cell Competition Shapes Metastatic Latency and Relapse.
Kim K, Huang H, Parida PK, He L, Marquez-Palencia M, Reese TC, Kapur P, Brugarolas J, Brekken RA, Malladi S, Cancer Discov 2022 Sep
VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment.
Zhang Y, Huang H, Coleman M, Ziemys A, Gopal P, Kazmi SM, Brekken RA, JCI Insight 2021 Oct


Featured Books Legend Featured Books

Honors & Awards

  • Henry C. Pitot Memorial Keynote Lecture Speaker, American Society for Matrix Biology
  • Center for Organogenesis Research and Trauma (CORT) Award, UTSW
  • K99/R00 Award, NIH/NCI
  • Best Presentation Award, Cancer Biology Program Retreat, UTSW
  • Best Poster Award, 8th International Meeting on Epithelial-Mesenchymal Transition

Professional Associations/Affiliations

  • American Association for Cancer Research (2018)
  • American Society for Cell Biology (2014)
  • International Society for Stem Cell Research (2021)