Biography

Dr. Huocong Huang received his medical degree from Sun Yat-sen University and his Ph.D. in Biochemistry and Molecular Biology from University of Nebraska Medical Center. His graduate research was mentored by Dr. Keith R. Johnson, focusing on the signaling transduction and protein interaction of collagen-induced cell plasticity. He then joined Dr. Rolf Brekken’s laboratory at UT Southwestern Medical Center for postdoctoral training. His postdoctoral research studied the function of cancer-associated fibroblasts and extracellular matrix in pancreatic ductal adenocarcinoma. He also examined the therapeutic potential of these stromal targets using animal models. Dr. Huang’s current research is focused on understanding the heterogeneity, origin and function of fibroblasts in physiological or pathological conditions including cancer, fibrosis, wound healing and aging.  

Education

Graduate School
Uni of Nebraska-Med Ctr (2016), Philosophy

Research Interest

  • Cancer-associated Fibroblast
  • Cell Biology
  • Fibrosis
  • Signal Transduction
  • Tumor Microenvironment

Publications

Featured Publications LegendFeatured Publications

Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics.
Layeghi-Ghalehsoukhteh S, Pal Choudhuri S, Ocal O, Zolghadri Y, Pashkov V, Niederstrasser H, Posner BA, Kantheti HS, Azevedo-Pouly AC, Huang H, Girard L, MacDonald RJ, Brekken RA, Wilkie TM, Sci Rep 2020 11 10 1 20662
Beyond stiffness: collagen signaling in pancreatic cancer and pancreas regeneration.
Huang H, Brekken RA, Am. J. Pathol. 2020 May
2-Amino-2, 3-Dihydro-1H-Indene-5-Carboxamide-Based Discoidin Domain Receptors 1 (DDR1) Inhibitors: Design, Synthesis, and In Vivo Anti-pancreatic Cancer Efficacy.
Zhu D, Huang H, Pinkas D, Luo J, Ganguly D, Fox AE, Arner E, Xiang Q, Tu ZC, Bullock AN, Brekken RA, Ding K, Lu X, J. Med. Chem. 2019 Jul

Books

Featured Books Legend Featured Books

Honors & Awards

  • Best Presentation Award, Cancer Biology Program Retreat, UTSW
    (2019)
  • Best Poster Award, 8th International Meeting on Epithelial-Mesenchymal Transition
    (2017)

Professional Associations/Affiliations

  • American Association for Cancer Research (2018)
  • American Society for Cell Biology (2014)