Tsinghua University (2008), Chemistry
Graduate School
Tsinghua University (2012), Life Sciences

Research Interest

  • Cholesterol Metabolism, Biosynthesis and Signaling
  • Lysosomal Membrane Proteins and Lysosomal Storage Diseases


Featured Publications LegendFeatured Publications

Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
Wang R, Qi X, Schmiege P, Coutavas E, Li X, Sci Adv 2020 Feb 6 7 eaaz1466
Structural insights into group II TRP channels.
Fine M, Li X, Dang S, Cell Calcium 2019 Nov 86 102107
Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.
Long T, Hassan A, Thompson BM, McDonald JG, Wang J, Li X, Nat Commun 2019 Jun 10 1 2452
Structural basis for PtdInsP2-mediated human TRPML1 regulation
Fine M, Schmiege P, Li X Nat Commun 2018 Oct 9 1 4192
The regulatory mechanism of mammalian TRPMLs revealed by cryo-EM.
Schmiege P, Fine M, Li X FEBS J. 2018 Mar
3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.
Li X, Lu F, Trinh MN, Schmiege P, Seemann J, Wang J, Blobel G Proc. Natl. Acad. Sci. U.S.A. 2017 Aug 114 34 9116-9121
Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
Trinh MN, Lu F, Li X, Das A, Liang Q, De Brabander JK, Brown MS, Goldstein JL Proc. Natl. Acad. Sci. U.S.A. 2016 Dec
Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.
Li X, Saha P, Li J, Blobel G, Pfeffer SR Proc. Natl. Acad. Sci. U.S.A. 2016 Aug
Structure of human Niemann-Pick C1 protein.
Li X, Wang J, Coutavas E, Shi H, Hao Q, Blobel G Proc. Natl. Acad. Sci. U.S.A. 2016 Jun
Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to ?-secretase.
Sun L, Li X, Shi Y Curr. Opin. Struct. Biol. 2016 Jan 37 97-107

Honors & Awards

  • Damon Runyon-Rachleff Innovation Award
  • Tri-Institutional (Memorial Sloan Kettering Cancer Research Center, Rockefeller University and Weill Cornell Medicine) Breakout Prize for Junior Investigators
  • The Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
  • C.H. Li Memorial Scholar Fund Award, Rockefeller University