Tsinghua University (2008), Chemistry
Graduate School
Tsinghua University (2012), Life Sciences

Research Interest

  • Cholesterol Metabolism
  • Hedgehog signaling pathway
  • Lysosomal membrane proteins and lysosomal storage diseases


Featured Publications LegendFeatured Publications

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
Trinh MN, Lu F, Li X, Das A, Liang Q, De Brabander JK, Brown MS, Goldstein JL Proc. Natl. Acad. Sci. U.S.A. 2016 Dec
Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.
Li X, Saha P, Li J, Blobel G, Pfeffer SR Proc. Natl. Acad. Sci. U.S.A. 2016 Aug
Structure of human Niemann-Pick C1 protein.
Li X, Wang J, Coutavas E, Shi H, Hao Q, Blobel G Proc. Natl. Acad. Sci. U.S.A. 2016 Jun
Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to ?-secretase.
Sun L, Li X, Shi Y Curr. Opin. Struct. Biol. 2016 Jan 37 97-107
Crystal structure of a phosphorylation-coupled vitamin C transporter.
Luo P, Yu X, Wang W, Fan S, Li X, Wang J Nat. Struct. Mol. Biol. 2015 Feb
Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum.
Li X, Roberti R, Blobel G Nature 2014 Oct
Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies.
Condon SM, Mitsuuchi Y, Deng Y, Laporte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, Burns JM, Graham MA, McKinlay MA, Li X, Wang J, Shi Y, Feltham R, Bettjeman B, Cumming MH, Vince JE, Khan N, Silke J, Day CL, Chunduru SK J. Med. Chem. 2014 Apr
Structure of a presenilin family intramembrane aspartate protease.
Li X, Dang S, Yan C, Gong X, Wang J, Shi Y Nature 2013 Jan 493 7430 56-61
Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE.
Li X, Wang J, Shi Y Nat Commun 2011 Aug 2 408
Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage.
Li X, Wang B, Feng L, Kang H, Qi Y, Wang J, Shi Y Proc. Natl. Acad. Sci. U.S.A. 2009 Sep 106 35 14837-42

Honors & Awards

  • Damon Runyon-Rachleff Innovation Award
  • Tri-Institutional (Memorial Sloan Kettering Cancer Research Center, Rockefeller University and Weill Cornell Medicine) Breakout Prize for Junior Investigators
  • The Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
  • C.H. Li Memorial Scholar Fund Award, Rockefeller University