Xiaochun Li, Ph.D.

Associate Professor

Endowed Title: Rita C. and William P. Clements, Jr. Scholar in Biomedical Research
School: Medical School
Department: Molecular Genetics | Biophysics
Graduate Programs: Cell and Molecular Biology, Molecular Biophysics

Education

Research Interest

Publications

Featured Publications

Cryo-EM structures of intact V-ATPase from bovine brain.: Wang R, Long T, Hassan A, Wang J, Sun Y, Xie XS, Li X, Nat Commun 2020 Aug 11 1 3921
Structure of nevanimibe-bound tetrameric human ACAT1.: Long T, Sun Y, Hassan A, Qi X, Li X, Nature 2020 May 581 7808 339-343
Structural basis for itraconazole-mediated NPC1 inhibition.: Long T, Qi X, Hassan A, Liang Q, De Brabander JK, Li X, Nat Commun 2020 Jan 11 1 152
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric G_i.: Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X, Nature 2019 Jun
Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.: Qi X, Schmiege P, Coutavas E, Li X Science 2018 Aug
Structures of human Patched and its complex with native palmitoylated sonic hedgehog.: Qi X, Schmiege P, Coutavas E, Wang J, Li X Nature 2018 Jul
Human TRPML1 channel structures in open and closed conformations.: Schmiege P, Fine M, Blobel G, Li X Nature 2017 Oct 550 7676 366-370
Inhibiting hedgehog signal by a patched-1 antibody.: Hu Q, Qi X, Donnelly L, Li X, Cell Discov 2025 Mar 11 1 29
Molecular basis of Spns1-mediated lysophospholipid transport from the lysosome.: Chen H, Ha HTT, Elghobashi-Meinhardt N, Le NA, Schmiege P, Nguyen LN, Li X, Proc Natl Acad Sci U S A 2025 Jan 122 1 e2409596121
Clues into Wnt cell surface signalosomes and its biogenesis.: Schmiege P, Li X, Trends Biochem Sci 2024 Oct

Books

Expression, Purification, and Structure Determination of Human PTCH1-HH-N Complexes. In Hedgehog Signaling

Xiaofeng Qi, Philip Schmiege, Leticia Esparza, Xiaochun Li (Ed.) (2022). New York, NY, Humana

A Structural Overview of TRPML1 and the TRPML Family. In Handb Exp Pharmacol

Michael Fine and Xiaochun Li (2022). Springer Nature

Honors & Awards

American Heart Association Established Investigator Award
(2023-2028)
Damon Runyon-Rachleff Innovation Award
(2019-2022)
Tri-Institutional (Memorial Sloan Kettering Cancer Research Center, Rockefeller University and Weill Cornell Medicine) Breakout Prize for Junior Investigators
(2017)
The Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
(2014-2017)
C.H. Li Memorial Scholar Fund Award, Rockefeller University
(2013)
The G. Harold and Leila Y. Mathers Foundation Award (2023-2025)