Tsinghua University (2008), Chemistry
Graduate School
Tsinghua University (2012), Life Sciences

Research Interest

  • Cholesterol Metabolism
  • Hedgehog signaling pathway
  • Lysosomal membrane proteins and lysosomal storage diseases


Featured Publications LegendFeatured Publications

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
Trinh MN, Lu F, Li X, Das A, Liang Q, De Brabander JK, Brown MS, Goldstein JL Proc. Natl. Acad. Sci. U.S.A. 2016 Dec
Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to ?-secretase.
Sun L, Li X, Shi Y Curr. Opin. Struct. Biol. 2016 Jan 37 97-107

Honors & Awards

  • Tri-Institutional (Memorial Sloan Kettering Cancer Research Center, Rockefeller University and Weill Cornell Medicine) Breakout Prize for Junior Investigators
  • The Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
  • C.H. Li Memorial Scholar Fund Award, Rockefeller University

Professional Associations/Affiliations

  • Department of Molecular Genetics, UT Southwestern Medical Center (2017)
  • Laboratory of Cell Biology, The Rockefeller University, New York, NY (2012-2017)
  • School of Life Sciences, Tsinghua University, Beijing, China (2012-2012)
  • School of Life Sciences, Tsinghua University, Beijing, China (2008-2012)
  • Department of Chemistry, Tsinghua University, Beijing, China (2004-2008)