Tsinghua University (2008), Chemistry
Graduate School
Tsinghua University (2012), Life Sciences

Research Interest

  • Cholesterol Metabolism
  • Hedgehog signaling pathway
  • Lysosomal membrane proteins and lysosomal storage diseases


Featured Publications LegendFeatured Publications

Structural insights into group II TRP channels.
Fine M, Li X, Dang S, Cell Calcium 2019 Nov 86 102107
The regulatory mechanism of mammalian TRPMLs revealed by cryo-EM.
Schmiege P, Fine M, Li X FEBS J. 2018 Mar
3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.
Li X, Lu F, Trinh MN, Schmiege P, Seemann J, Wang J, Blobel G Proc. Natl. Acad. Sci. U.S.A. 2017 Aug 114 34 9116-9121

Honors & Awards

  • Damon Runyon-Rachleff Innovation Award
  • Tri-Institutional (Memorial Sloan Kettering Cancer Research Center, Rockefeller University and Weill Cornell Medicine) Breakout Prize for Junior Investigators
  • The Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
  • C.H. Li Memorial Scholar Fund Award, Rockefeller University