Xiaochun Li, Ph.D.
Associate Professor

Undergraduate

Tsinghua University (2008), Chemistry

Graduate School

Tsinghua University (2012), Life Sciences

• Lipid Metabolism and Signaling
• Lysosomal Membrane Proteins and Lysosomal Storage Diseases

Featured Publications

Structure of S1PR2-heterotrimeric G₁₃ signaling complex.

Chen H, Chen K, Huang W, Staudt LM, Cyster JG, Li X, Sci Adv 2022 Apr 8 13 eabn0067

Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states

Sun Y and Li X Nature Cardiovascular Research 2022 1 238-245

Molecular basis of cholesterol efflux via ABCG subfamily transporters.

Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X, Proc Natl Acad Sci U S A 2021 Aug 118 34

Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.

Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X, Sci Adv 2021 Aug 7 34

Molecular basis of V-ATPase inhibition by bafilomycin A1.

Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X, Nat Commun 2021 03 12 1 1782

Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.

Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X, Nat. Chem. Biol. 2020 Sep

Cryo-EM structures of intact V-ATPase from bovine brain.

Wang R, Long T, Hassan A, Wang J, Sun Y, Xie XS, Li X, Nat Commun 2020 Aug 11 1 3921

Structure of nevanimibe-bound tetrameric human ACAT1.

Long T, Sun Y, Hassan A, Qi X, Li X, Nature 2020 May 581 7808 339-343

Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.

Wang R, Qi X, Schmiege P, Coutavas E, Li X, Sci Adv 2020 Feb 6 7 eaaz1466

Structural basis for itraconazole-mediated NPC1 inhibition.

Long T, Qi X, Hassan A, Liang Q, De Brabander JK, Li X, Nat Commun 2020 Jan 11 1 152

 Featured Books

Expression, Purification, and Structure Determination of Human PTCH1-HH-N Complexes. In Hedgehog Signaling

Xiaofeng Qi, Philip Schmiege, Leticia Esparza, Xiaochun Li (Ed.) (2022). New York, NY, Humana

• Damon Runyon-Rachleff Innovation Award
  (2019-2022)
• Tri-Institutional (Memorial Sloan Kettering Cancer Research Center, Rockefeller University and Weill Cornell Medicine) Breakout Prize for Junior Investigators
  (2017)
• The Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
  (2014-2017)
• C.H. Li Memorial Scholar Fund Award, Rockefeller University
  (2013)