
Xiaochun Li, Ph.D.
Associate Professor
Endowed Title Rita C. and William P. Clements, Jr. Scholar in Biomedical Research
Department Molecular Genetics | Biophysics
Graduate Programs Cell and Molecular Biology, Molecular Biophysics
Education
- Undergraduate
- Tsinghua University (2008), Chemistry
- Graduate School
- Tsinghua University (2012), Life Sciences
Research Interest
- Lipid Metabolism and Signaling
- Lysosomal Membrane Proteins and Lysosomal Storage Diseases
Publications
Featured Publications
- Structure of S1PR2-heterotrimeric G13 signaling complex.
- Chen H, Chen K, Huang W, Staudt LM, Cyster JG, Li X, Sci Adv 2022 Apr 8 13 eabn0067
- Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states
- Sun Y and Li X Nature Cardiovascular Research 2022 1 238-245
- Molecular basis of cholesterol efflux via ABCG subfamily transporters.
- Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X, Proc Natl Acad Sci U S A 2021 Aug 118 34
- Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
- Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X, Sci Adv 2021 Aug 7 34
- Molecular basis of V-ATPase inhibition by bafilomycin A1.
- Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X, Nat Commun 2021 03 12 1 1782
- Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
- Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X, Nat. Chem. Biol. 2020 Sep
- Cryo-EM structures of intact V-ATPase from bovine brain.
- Wang R, Long T, Hassan A, Wang J, Sun Y, Xie XS, Li X, Nat Commun 2020 Aug 11 1 3921
- Structure of nevanimibe-bound tetrameric human ACAT1.
- Long T, Sun Y, Hassan A, Qi X, Li X, Nature 2020 May 581 7808 339-343
- Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
- Wang R, Qi X, Schmiege P, Coutavas E, Li X, Sci Adv 2020 Feb 6 7 eaaz1466
- Structural basis for itraconazole-mediated NPC1 inhibition.
- Long T, Qi X, Hassan A, Liang Q, De Brabander JK, Li X, Nat Commun 2020 Jan 11 1 152
Books
Featured Books
Expression, Purification, and Structure Determination of Human PTCH1-HH-N Complexes. In Hedgehog Signaling
Xiaofeng Qi, Philip Schmiege, Leticia Esparza, Xiaochun Li (Ed.) (2022). New York, NY, Humana
Honors & Awards
- Damon Runyon-Rachleff Innovation Award
(2019-2022) - Tri-Institutional (Memorial Sloan Kettering Cancer Research Center, Rockefeller University and Weill Cornell Medicine) Breakout Prize for Junior Investigators
(2017) - The Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
(2014-2017) - C.H. Li Memorial Scholar Fund Award, Rockefeller University
(2013)