Xiaochun Li, Ph.D.
Assistant Professor
Endowed Title Rita C. and William P. Clements, Jr. Scholar in Biomedical Research
Department Molecular Genetics | Biophysics
Graduate Programs Cell and Molecular Biology, Molecular Biophysics
Education
- Undergraduate
- Tsinghua University (2008), Chemistry
- Graduate School
- Tsinghua University (2012), Life Sciences
Research Interest
- Cholesterol Metabolism
- Hedgehog signaling pathway
- Lysosomal membrane proteins and lysosomal storage diseases
Publications
Featured Publications
- Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
- Wang R, Qi X, Schmiege P, Coutavas E, Li X, Sci Adv 2020 Feb 6 7 eaaz1466
- Structural basis for itraconazole-mediated NPC1 inhibition.
- Long T, Qi X, Hassan A, Liang Q, De Brabander JK, Li X, Nat Commun 2020 Jan 11 1 152
- Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.
- Long T, Hassan A, Thompson BM, McDonald JG, Wang J, Li X, Nat Commun 2019 Jun 10 1 2452
- Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
- Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X, Nature 2019 Jun
- Structural basis for PtdInsP2-mediated human TRPML1 regulation
- Fine M, Schmiege P, Li X Nat Commun 2018 Oct 9 1 4192
- Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
- Qi X, Schmiege P, Coutavas E, Li X Science 2018 Aug
- Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
- Qi X, Schmiege P, Coutavas E, Wang J, Li X Nature 2018 Jul
- Human TRPML1 channel structures in open and closed conformations.
- Schmiege P, Fine M, Blobel G, Li X Nature 2017 Oct 550 7676 366-370
- Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling
- Xiaofeng Qi and Xiaochun Li Trends in Biochemical Sciences 2020 published online
- Structural insights into group II TRP channels.
- Fine M, Li X, Dang S, Cell Calcium 2019 Nov 86 102107
Honors & Awards
- Damon Runyon-Rachleff Innovation Award
(2019) - Tri-Institutional (Memorial Sloan Kettering Cancer Research Center, Rockefeller University and Weill Cornell Medicine) Breakout Prize for Junior Investigators
(2017) - The Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
(2014-2017) - C.H. Li Memorial Scholar Fund Award, Rockefeller University
(2013-2013)