Xiaochun Li, Ph.D.

Undergraduate

Tsinghua University (2008), Chemistry

Graduate School

Tsinghua University (2012), Life Sciences

• Lipid Metabolism and Signaling
• Lysosomal Membrane Proteins and Lysosomal Storage Diseases

Featured Publications

Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.

Qi X, Hu Q, Elghobashi-Meinhardt N, Long T, Chen H, Li X, Cell 2023 Oct

Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.

Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X, Nat Struct Mol Biol 2023 Sep

Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.

Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH, Cell 2023 May

Structure and mechanism of human cystine exporter cystinosin.

Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X, Cell 2022 Sep

Mechanisms and inhibition of Porcupine-mediated Wnt acylation.

Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X, Nature 2022 Jul

Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.

Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X, Nat Commun 2022 Jul 13 1 4273

Molecular basis of cholesterol efflux via ABCG subfamily transporters.

Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X, Proc Natl Acad Sci U S A 2021 Aug 118 34

Molecular basis of V-ATPase inhibition by bafilomycin A1.

Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X, Nat Commun 2021 03 12 1 1782

Cryo-EM structures of intact V-ATPase from bovine brain.

Wang R, Long T, Hassan A, Wang J, Sun Y, Xie XS, Li X, Nat Commun 2020 Aug 11 1 3921

Structure of nevanimibe-bound tetrameric human ACAT1.

Long T, Sun Y, Hassan A, Qi X, Li X, Nature 2020 May 581 7808 339-343

 Featured Books

Expression, Purification, and Structure Determination of Human PTCH1-HH-N Complexes. In Hedgehog Signaling

Xiaofeng Qi, Philip Schmiege, Leticia Esparza, Xiaochun Li (Ed.) (2022). New York, NY, Humana

A Structural Overview of TRPML1 and the TRPML Family. In Handb Exp Pharmacol

Michael Fine and Xiaochun Li (2022). Springer Nature

• American Heart Association Established Investigator Award
  (2023-2028)
• Damon Runyon-Rachleff Innovation Award
  (2019-2022)
• Tri-Institutional (Memorial Sloan Kettering Cancer Research Center, Rockefeller University and Weill Cornell Medicine) Breakout Prize for Junior Investigators
  (2017)
• The Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
  (2014-2017)
• C.H. Li Memorial Scholar Fund Award, Rockefeller University
  (2013)
• The G. Harold and Leila Y. Mathers Foundation Award (2023-2025)