Xiaochun Li, Ph.D.
Assistant Professor

Undergraduate

Tsinghua University (2008), Chemistry

Graduate School

Tsinghua University (2012), Life Sciences

Featured Publications

Human TRPML1 channel structures in open and closed conformations.

Schmiege P, Fine M, Blobel G, Li X Nature 2017 Oct 550 7676 366-370

3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.

Li X, Lu F, Trinh MN, Schmiege P, Seemann J, Wang J, Blobel G Proc. Natl. Acad. Sci. U.S.A. 2017 Aug 114 34 9116-9121

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.

Li X, Saha P, Li J, Blobel G, Pfeffer SR Proc. Natl. Acad. Sci. U.S.A. 2016 Aug

Structure of human Niemann-Pick C1 protein.

Li X, Wang J, Coutavas E, Shi H, Hao Q, Blobel G Proc. Natl. Acad. Sci. U.S.A. 2016 Jun

Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum.

Li X, Roberti R, Blobel G Nature 2014 Oct

Structure of a presenilin family intramembrane aspartate protease.

Li X, Dang S, Yan C, Gong X, Wang J, Shi Y Nature 2013 Jan 493 7430 56-61

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.

Trinh MN, Lu F, Li X, Das A, Liang Q, De Brabander JK, Brown MS, Goldstein JL Proc. Natl. Acad. Sci. U.S.A. 2016 Dec

Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to ?-secretase.

Sun L, Li X, Shi Y Curr. Opin. Struct. Biol. 2016 Jan 37 97-107

Crystal structure of a phosphorylation-coupled vitamin C transporter.

Luo P, Yu X, Wang W, Fan S, Li X, Wang J Nat. Struct. Mol. Biol. 2015 Feb

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies.

Condon SM, Mitsuuchi Y, Deng Y, Laporte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, Burns JM, Graham MA, McKinlay MA, Li X, Wang J, Shi Y, Feltham R, Bettjeman B, Cumming MH, Vince JE, Khan N, Silke J, Day CL, Chunduru SK J. Med. Chem. 2014 Apr

• Tri-Institutional (Memorial Sloan Kettering Cancer Research Center, Rockefeller University and Weill Cornell Medicine) Breakout Prize for Junior Investigators
  (2017)
• The Gordon and Betty Moore Foundation Fellow of the Life Sciences Research Foundation
  (2014-2017)
• C.H. Li Memorial Scholar Fund Award, Rockefeller University
  (2013-2013)

• Department of Molecular Genetics, UT Southwestern Medical Center (2017)
• Laboratory of Cell Biology, The Rockefeller University, New York, NY (2012-2017)
• School of Life Sciences, Tsinghua University, Beijing, China (2012-2012)
• School of Life Sciences, Tsinghua University, Beijing, China (2008-2012)
• Department of Chemistry, Tsinghua University, Beijing, China (2004-2008)