Dr. Taurog has been a faculty member in the Division of Rheumatic Diseases at UT Southwestern since 1986. Since joining the faculty he has served as attending physician in rheumatology and internal medicine at Parkland Memorial Hospital. From 1980 to 1986 he was a faculty member in rheumatology and internal medicine at the University of Minnesota in Minneapolis. 

The goal of Dr. Taurog's research has been to understand the molecular basis for the association of the rheumatic disease called ankylosing spondylitis with the major histocompatibility allele HLA-B27. This MHC class I allele is found in 7 percent of the U.S. population, but in over 90 percent of individuals with ankylosing spondylitis. Of individuals with B27, it is estimated that up to 13 percent will develop ankylosing spondylitis or a related form of spondyloarthritis. 

Dr. Taurog's efforts largely involve the study of rats transgenic for HLA-B27 and its associated light chain, beta-2-microglobulin. The rats develop a spontaneous arthritis and spondylitis that in many ways mimics the spectrum of the human spondyloarthropathies. 

We have used a variety of cellular, genetic, biochemical and microbiological approaches have been used to try to understand the role of the B27 molecule in the pathogenesis of this experimental disorder.


Medical School
UT Southwestern Medical Center (1974)
Harvard Medical School/Brigham & Women's Hospital (1975), Int. Medicine
Harvard Medical School/Brigham & Women's Hospital (1976), Int. Medicine
National Institutes of Health-Research (1980), Immunology/rheumatology

Research Interest

  • Role of HLA-B27 in Spondyloarthritis


Featured Publications LegendFeatured Publications

Loss of bone strength in HLA-B27 transgenic rats is characterized by a high bone turnover and is mainly osteoclast-driven.
Rauner M, Thiele S, Fert I, Araujo LM, Layh-Schmitt G, Colbert RA, Hofbauer C, Bernhardt R, Bürki A, Schwiedrzik J, Zysset PK, Pietschmann P, Taurog JD, Breban M, Hofbauer LC Bone 2015 Mar 75 183-191
Role of PPM1A and anti-PPM1A Autoantibodies in Ankylosing Spondylitis.
Kim YG, Sohn DH, Zhao X, Sokolove J, Lindstrom TM, Yoo B, Lee CK, Reveille JD, Taurog JD, Robinson WH Arthritis & rheumatology (Hoboken, N.J.) 2014 Jun
Reverse interferon signature is characteristic of antigen-presenting cells in human and rat spondyloarthritis.
Fert I, Cagnard N, Glatigny S, Letourneur F, Jacques S, Smith JA, Colbert RA, Taurog JD, Chiocchia G, Araujo LM, Breban M Arthritis & rheumatology (Hoboken, N.J.) 2014 Apr 66 4 841-51

Honors & Awards

  • Master of the American College of Rheumatology
  • Glenn Clark Lectureship
    University of Tennessee, Memphis (2008)
  • William M. & Gatha Burnett Professorship for Arthritis Research
    UT Southwestern Medical Center (1997)
  • Kroc Lectureship
    University of Michigan (1993)
  • Carol-Nachman Prize for Rheumatology
    State Capital of Wiesbaden, Germany (1992)
  • Rheumatologist of the Year
    Abstract Rhumato (French Journal) (1991)

Professional Associations/Affiliations

  • American Society for Clinical Investigation (1991)
  • American Association of Immunologists (1980)
  • American College of Rheumatology (1980)