Dr. Guo-Min Li is a professor of Radiation Oncology and Director of the Reece A. Overcash Jr. Center for Research on Colon Cancer, in Honor of Dr. Eugene Frenkel, at UT Southwestern. He received his BS and MS degrees in biology from Wuhan University in China and his Ph.D. degree in chemistry from Wayne State University. He performed his postdoctoral training with Nobel laureate Dr. Paul Modrich (Chemistry, 2015) at Duke University. Before joining UT Southwestern, Dr. Li held professorship at the University of Kentucky and the University of Southern California.
Dr. Li studies DNA mismatch repair (MMR), an important cellular mechanism that ensures replication fidelity. His work has contributed to the understanding of MMR and its role in cancer susceptibility and therapy. He discovered MMR defects as the genetic basis of hereditary non-polyposis colorectal cancer and sporadic colorectal cancers displaying microsatellite instability. He identified and characterized the majority of components required for human MMR, and reconstituted the human MMR reaction in vitro. Recently, his laboratory has discovered epigenetic factors as important MMR components/regulators, including histone modifications and non-coding RNAs. He is also responsible for discovering the apoptotic function of MMR, in which MMR proteins recognize chemically and physically adducted DNA and trigger a futile repair cycle to induce cell death, implicating MMR in cancer therapy. In addition, his lab has also elucidated the mechanism by which the mismatch repair system promotes (CAG)•(CTG) trinucleotide repeat expansion that causes many neurodegenerative disorders.
- Wuhan University (1982), Botany
- Graduate School
- Wuhan University (1985), Genetics
- Graduate School
- Wayne State University (1991), Chemistry
- DNA mismatch repair in neurodegenerative diseases
- Mechanistic studies of DNA mismatch repair
- Targeting DNA mismatch repair factors in cancer therapy
- Mispair-bound human MutS-MutL complex triggers DNA incisions and activates mismatch repair.
- Ortega J, Lee GS, Gu L, Yang W, Li GM, Cell Res 2021 Jan
- MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.
- Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM, Cancer Cell 2020 Dec
- DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.
- Lu C, Guan J, Lu S, Jin Q, Rousseau B, Lu T, Stephens D, Zhang H, Zhu J, Yang M, Ren Z, Liang Y, Liu Z, Han C, Liu L, Cao X, Zhang A, Qiao J, Batten K, Chen M, Castrillon DH, Wang T, Li B, Diaz LA, Li GM, Fu YX, Cancer Cell 2020 Nov
- Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSa interaction.
- Fang J, Huang Y, Mao G, Yang S, Rennert G, Gu L, Li H, Li GM Proc. Natl. Acad. Sci. U.S.A. 2018 Sep
- The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSa.
- Li F, Mao G, Tong D, Huang J, Gu L, Yang W, Li GM Cell 2013 Apr 153 3 590-600
- Reconstitution of 5'-directed human mismatch repair in a purified system.
- Zhang Y, Yuan F, Presnell SR, Tian K, Gao Y, Tomkinson AE, Gu L, Li GM Cell 2005 Sep 122 5 693-705
- Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.
- Drummond JT, Li GM, Longley MJ, Modrich P Science 1995 Jun 268 5219 1909-12
- Hypermutability and mismatch repair deficiency in RER+ tumor cells.
- Parsons R, Li GM, Longley MJ, Fang WH, Papadopoulos N, Jen J, de la Chapelle A, Kinzler KW, Vogelstein B, Modrich P Cell 1993 Dec 75 6 1227-36
- NBS1-CtIP-mediated DNA end resection suppresses cGAS binding to micronuclei.
- Abdisalaam S, Mukherjee S, Bhattacharya S, Kumari S, Sinha D, Ortega J, Li GM, Sadek HA, Krishnan S, Asaithamby A, Nucleic Acids Res 2022 Feb
- DNA polymerase ? promotes CAG?CTG repeat expansions in Huntington's disease via insertion sequences of its catalytic domain.
- Chan KY, Li X, Ortega J, Gu L, Li GM, J Biol Chem 2021 Aug 297 4 101144
- Professor, UT Southwestern (2017)
- Professor, University of Southern California (2015-2017)
- Professor, University of Kentucky (1995-2015)
- Postdoctoral fellow, Duke University (1991-1995)