Research Interest

  • Bioinformatics
  • Computational Biology
  • Computational Oncology
  • Machine Learning

Publications

Featured Publications LegendFeatured Publications

Completeness and Consistency in Structural Domain Classifications.
Schaeffer RD, Kinch LN, Pei J, Medvedev KE, Grishin NV, ACS Omega 2021 Jun 6 24 15698-15707
Recent advances suggest increased influence of selective pressure in allostery.
Bhat AS, Dustin Schaeffer R, Kinch L, Medvedev KE, Grishin NV, Curr Opin Struct Biol 2020 06 62 183-188
ECOD: identification of distant homology among multidomain and transmembrane domain proteins.
Schaeffer RD, Kinch L, Medvedev KE, Pei J, Cheng H, Grishin N, BMC Mol Cell Biol 2019 06 20 1 18
Functional and evolutionary analysis of viral proteins containing a Rossmann-like fold.
Medvedev KE, Kinch LN, Grishin NV, Protein Sci 2018 08 27 8 1450-1463
High temperature and pressure influence the interdomain orientation of Nip7 proteins from P. abyssi and P. furiosus: MD simulations.
Medvedev KE, Kolchanov NA, Afonnikov DA, J Biomol Struct Dyn 2018 01 36 1 68-82
Identification of residues of the archaeal RNA-binding Nip7 proteins specific to environmental conditions.
Medvedev KE, Kolchanov NA, Afonnikov DA, J Bioinform Comput Biol 2017 Apr 15 2 1650036
Molecular dynamics simulations of the Nip7 proteins from the marine deep- and shallow-water Pyrococcus species.
Medvedev KE, Alemasov NA, Vorobjev YN, Boldyreva EV, Kolchanov NA, Afonnikov DA, BMC Struct Biol 2014 Oct 14 23
Important role of hydrophobic interactions in high-pressure adaptation of proteins.
Afonnikov DA, Medvedev KE, Gunbin KV, Kolchanov NA, Dokl Biochem Biophys 2011 May-Jun 438 113-6