Non-muscle cell movements are essential for many cellular functions, to repair tissues, to fight infection and to orchestrate normal development. The actin cytoskeleton assembles into scaffolds to support the motile machinery of the cell, and the scaffolds are remodeled during cell signaling and dismantled during apoptosis.
Dr. Sun’s main research projects at UT Southwestern focus on the function of lipid kinases that synthesize PIP2 (Phosphatidylinositol Phosphate 5 Kinases and 4 Kinases ) and the regulatory proteins that respond to PIP2, and how proteins can regulate dynamic actin remodeling in response to membrane signaling. Dr. Sun is currently Co-Director of the Imaging Facility within the Department of Physiology.
- Graduate School
- Fudan University (1977)
- Membrane signaling
- Regulation of the cell cytoskeleton
- Effects of CapG overexpression on agonist-induced motility and second messenger generation
- Sun HQ, Kwiatkowska K, Wooten DC, Yin HL J Cell Biol April 1995 129(1) 147-56
- Actin monomer binding proteins
- Sun HQ, Kwiatkowska K, Yin HL Curr Opin Cell Biol February 1995 7(1) 102-10
- The actin side-binding domain of gelsolin also caps actin filaments. Implications for actin filament severing
- Sun HQ, Wooten DC, Janmey PA, Yin HL J Biol Chem April 1994 269(13) 9473-9