Mingyi Chen, M.D., Ph.D.
Associate Professor

Medical School

Peking University Health Science Center, China (1992)

Graduate School

Kyoto University, Japan (2001), Pharmacology

Postdoctoral Fellowship

UCLA/Howard Hughes Medical Institute (2005), Pathology/lab Medicine

Internship

UC San Diego Health (2006), Pathology

Residency

Loma Linda University Medical Center (2009), Pathology

Fellowship

City of Hope National Medical Center (2010), Hematopathology

• Molecular pathogenesis of lymphoma and leukemia, tumor immunology and GVHD
• Sickle cell disease, thrombosis, and vascular biology
• Viral infections and cancergenesis, and cancer stem cells

Featured Publications

Clonal Deletion of Tumor-Specific T Cells by Interferon-? Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.

Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L Immunity 2019 Feb

Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.

Pai CS, Simons DM, Lu X, Evans M, Wei J, Wang YH, Chen M, Huang J, Park C, Chang A, Wang J, Westmoreland S, Beam C, Banach D, Bowley D, Dong F, Seagal J, Ritacco W, Richardson PL, Mitra S, Lynch G, Bousquet P, Mankovich J, Kingsbury G, Fong L J. Clin. Invest. 2018 Dec

Disruption of the Rbm38-eIF4E complex with a synthetic peptide Pep8 increases p53 expression.

Lucchesi CA, Zhang J, Ma B, Chen M, Chen X Cancer Res. 2018 Dec

An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors.

Wang T, Lu R, Kapur P, Jaiswal BS, Hannan R, Zhang Z, Pedrosa I, Luke JJ, Zhang H, Goldstein LD, Yousuf Q, Gu YF, McKenzie T, Joyce A, Kim MS, Wang X, Luo D, Onabolu O, Stevens C, Xie Z, Chen M, Filatenkov A, Torrealba J, Luo X, Guo W, He J, Stawiski E, Modrusan Z, Durinck S, Seshagiri S, Brugarolas J Cancer Discov 2018 Jun

Alterations in cancer stem-cell marker CD44 expression predict oncologic outcome in soft-tissue sarcomas.

Henderson T, Chen M, Darrow MA, Li CS, Chiu CL, Monjazeb AM, Murphy WJ, Canter RJ J. Surg. Res. 2018 Mar 223 207-214

The Rbm38-p63 feedback loop is critical for tumor suppression and longevity.

Jiang Y, Xu E, Zhang J, Chen M, Flores E, Chen X Oncogene 2018 Mar

PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression.

Tang H, Liang Y, Anders RA, Taube JM, Qiu X, Mulgaonkar A, Liu X, Harrington SM, Guo J, Xin Y, Xiong Y, Nham K, Silvers W, Hao G, Sun X, Chen M, Hannan R, Qiao J, Dong H, Peng H, Fu YX J. Clin. Invest. 2018 Feb 128 2 580-588

CD3-positive plasmablastic B-cell neoplasms: a diagnostic pitfall.

Pan Z, Chen M, Zhang Q, Wang E, Yin L, Xu Y, Huang Q, Yuan Y, Zhang X, Zheng G, Yuan J Mod. Pathol. 2018 Jan

Erythrophagocytosis by T-cell lymphoma cells in a patient with hereditary spherocytosis post-splenectomy.

Frame IJ, Coberly J, Fuda FS, Chen M Br. J. Haematol. 2017 Nov

Enumeration of bone marrow plasmacytoid dendritic cells by multiparameter flow cytometry as a prognostic marker following allogeneic hematopoietic stem cell transplantation.

Su RJ, Green R, Chen M Blood Cells Mol. Dis. 2017 Oct

 Featured Books

Hematological disorders following bariatric surgery.. In Pathophysiology of Bariatric Surgery: Metabolism, Nutrition, Procedures, Outcomes and Adverse Effects.

Qiu H, Green R, Chen M (2016). Victor Preedy, (ed), Academic Press.

Molecular Biology of Glycogen Storage Diseases. In Molecular Pathology of Liver Diseases

Chen M. (2010). Springer's ISBN 978-1-4419-7106-7, pp. 677-682., P.S. Monga. eds. Philip T. Cagle, editor., (ed),