Mingyi Chen, M.D., Ph.D.
Associate Professor

Medical School

Peking University Health Science Center, China (1992)

Graduate School

Kyoto University, Japan (2001), Pharmacology

Postdoctoral Fellowship

UCLA/Howard Hughes Medical Institute (2005), Pathology/lab Medicine

Internship

UC San Diego Health (2006), Pathology

Residency

Loma Linda University Medical Center (2009), Pathology

Fellowship

City of Hope National Medical Center (2010), Hematopathology

• Molecular pathogenesis of lymphoma and leukemia, tumor immunology and GVHD
• Sickle cell disease, thrombosis, and vascular biology
• Viral infections and cancergenesis, and cancer stem cells

Featured Publications

Philadelphia chromosome-negative acute leukemia in chronic myeloid leukemia.

Gong Z, Xu ML, Chen M, Cui W, Kantarjian HM, Cortes JE, Zhou T, Tang G, Wang W, Medeiros LJ, Hu S, Am. J. Hematol. 2019 Jul

Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis.

Zhang Y, Feng X, Zhang J, Chen M, Huang E, Chen X, Oncogene 2019 Jul

CD123 a novel biomaker for diagnosis and treatment of leukemia.

Shi M, Jeanna Su R, Parmar KP, Chaudhry R, Sun K, Rao J, Chen M, Cardiovasc Hematol Disord Drug Targets 2019 Jun

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation.

Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J, Cancer Discov 2019 Jun

Mantle Cell Lymphoma With Mantle Zone Growth Pattern.

Yuan J, Li S, Liu X, Su RJ, Chen M, Wu X, Zheng G, Smith LM, Wang L, Li Y, Liu C, Zhou J, Shen Q, Zhang L, Wang E, Xu ML, Pan Z, Am. J. Clin. Pathol. 2019 May

Clonal Deletion of Tumor-Specific T Cells by Interferon-? Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.

Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L Immunity 2019 Feb

Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.

Pai CS, Simons DM, Lu X, Evans M, Wei J, Wang YH, Chen M, Huang J, Park C, Chang A, Wang J, Westmoreland S, Beam C, Banach D, Bowley D, Dong F, Seagal J, Ritacco W, Richardson PL, Mitra S, Lynch G, Bousquet P, Mankovich J, Kingsbury G, Fong L J. Clin. Invest. 2018 Dec

Disruption of the Rbm38-eIF4E complex with a synthetic peptide Pep8 increases p53 expression.

Lucchesi CA, Zhang J, Ma B, Chen M, Chen X Cancer Res. 2018 Dec

An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors.

Wang T, Lu R, Kapur P, Jaiswal BS, Hannan R, Zhang Z, Pedrosa I, Luke JJ, Zhang H, Goldstein LD, Yousuf Q, Gu YF, McKenzie T, Joyce A, Kim MS, Wang X, Luo D, Onabolu O, Stevens C, Xie Z, Chen M, Filatenkov A, Torrealba J, Luo X, Guo W, He J, Stawiski E, Modrusan Z, Durinck S, Seshagiri S, Brugarolas J Cancer Discov 2018 Jun

Alterations in cancer stem-cell marker CD44 expression predict oncologic outcome in soft-tissue sarcomas.

Henderson T, Chen M, Darrow MA, Li CS, Chiu CL, Monjazeb AM, Murphy WJ, Canter RJ J. Surg. Res. 2018 Mar 223 207-214

 Featured Books

Hematological disorders following bariatric surgery.. In Pathophysiology of Bariatric Surgery: Metabolism, Nutrition, Procedures, Outcomes and Adverse Effects.

Qiu H, Green R, Chen M (2016). Victor Preedy, (ed), Academic Press.

Molecular Biology of Glycogen Storage Diseases. In Molecular Pathology of Liver Diseases

Chen M. (2010). Springer's ISBN 978-1-4419-7106-7, pp. 677-682., P.S. Monga. eds. Philip T. Cagle, editor., (ed),