Gaurav Sharma, Ph.D.

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Gaurav Sharma, Ph.D., MBA, is an Assistant Professor in the Department of Cardiovascular and Thoracic Surgery at UT Southwestern Medical Center. He earned a B.Sc. in Biological Sciences and an M.Sc. in Biotechnology, followed by a Ph.D. in Biomedical Sciences. Additionally, he obtained an MBA from the Quantic School of Business and Technology, Washington, DC. His Ph.D. from the All India Institute of Medical Sciences (AIIMS) utilized NMR and LCMS metabolomics to characterize and elucidate the drug response of anticancer formulations. Dr. Sharma conducted postdoctoral research in intermediary metabolism and metabolic imaging at the Advanced Imaging Research Center at UT Southwestern Medical Center.

Dr. Sharma is a recipient of predoctoral and postdoctoral fellowships from the Indian Council of Medical Research (ICMR) and the American Heart Association (AHA), respectively. Most recently, he has been awarded the Second Century Early Faculty Independence Award from the American Heart Association (AHA). Currently, he serves as a member of editorial boards for several journals, including The Journal of Heart and Lung Transplantation-Open, Journal of Translational Medicine, Frontiers in Cardiovascular Medicine, BMC Cardiovascular Disorders, BMC Cancer, PeerJ, Heliyon, and Medicine. Additionally, he has served as an ad hoc peer reviewer for more than 40 international peer-reviewed and indexed scientific journals. He also serves as a member of study sections for several national and international grant study sections

Dr. Sharma’s lab focuses on understanding the role of altered metabolic states in biological systems, including cardiovascular and metabolic diseases. This research is tightly integrated with clinical activities in cardiothoracic surgery, enabling seamless possibilities to assess the applicability of findings in patients and assist cardiothoracic surgeons in clinical decision-making.

Graduate School

All India Inst of Medical Sci , Biomedical Sciences

Graduate School

Quantic School Business & Tech , Business Administration

• Cardiovascular & Metabolic Diseases
• Hyperpolarized Carbon-13 Metabolic Imaging
• Magnetic Resonance Spectroscopy/Imaging (MRS/I)
• Metabolic Flux Analysis
• Metabolomics in the Heart, Lung, and Perfusion Preservation
• NMR and MS metabolomics
• Stable Isotope Tracers for Assessing Metabolism in vivo and ex vivo

Featured Publications

Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver.

Jin ES, Malloy CR, Sharma G, Finn E, Fuller KNZ, Reyes YG, Lovell MA, Derderian SC, Schoen JA, Inge TH, Cree MG, Redox Biol 2023 Jul 63 102749

Oxidation of hyperpolarized [1-¹³ C]pyruvate in isolated rat kidneys.

Sharma G, Maptue N, Rahim M, Mijes MLT, Hever T, Wen X, Funk AM, Malloy CR, Young JD, Khemtong C, NMR Biomed 2022 Oct e4857

Co-Polarized [1-¹³C]Pyruvate and [1,3-¹³C₂]Acetoacetate Provide a Simultaneous View of Cytosolic and Mitochondrial Redox in a Single Experiment.

Sharma G, Wen X, Maptue NR, Hever T, Malloy CR, Sherry AD, Khemtong C, ACS Sens 2021 11 6 11 3967-3977

PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.

Li Q, Li C, Elnwasany A, Sharma G, An YA, Zhang G, Elhelaly WM, Lin J, Gong Y, Chen G, Wang M, Zhao S, Dai C, Smart CD, Liu J, Luo X, Deng Y, Tan L, Lv SJ, Davidson SM, Locasale JW, Lorenzi PL, Malloy CR, Gillette TG, Vander Heiden MG, Scherer PE, Szweda LI, Fu G, Wang ZV, Circulation 2021 08 144 9 712-727

Real-time hyperpolarized ¹³C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4-double knockout mouse livers.

Sharma G, Wu CY, Wynn RM, Gui W, Malloy CR, Sherry AD, Chuang DT, Khemtong C, Sci Rep 2019 Nov 9 1 16480

Metabolism of hyperpolarized ¹³ C-acetoacetate to ?-hydroxybutyrate detects real-time mitochondrial redox state and dysfunction in heart tissue.

Chen W, Sharma G, Jiang W, Maptue NR, Malloy CR, Sherry AD, Khemtong C, NMR Biomed 2019 Apr e4091

MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid ?-Oxidation.

Makarewich CA, Baskin KK, Munir AZ, Bezprozvannaya S, Sharma G, Khemtong C, Shah AM, McAnally JR, Malloy CR, Szweda LI, Bassel-Duby R, Olson EN Cell Rep 2018 Jun 23 13 3701-3709

Enhancing Cancer Diagnosis with Real-Time Feedback: Tumor Metabolism through Hyperpolarized 1-¹³C Pyruvate MRSI.

Sharma G, Enriquez JS, Armijo R, Wang M, Bhattacharya P, Pudakalakatti S, Metabolites 2023 Apr 13 5

Aflatoxin B1 Toxicity and Protective Effects of Curcumin: Molecular Mechanisms and Clinical Implications.

Dai C, Tian E, Hao Z, Tang S, Wang Z, Sharma G, Jiang H, Shen J, Antioxidants (Basel) 2022 Oct 11 10

Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway.

Dai C, Zhang Q, Shen L, Sharma G, Jiang H, Wang Z, Shen J, Antioxidants (Basel) 2022 Jul 11 8

• Fellow, American College of Cardiology
  (2024)
• Awarded 1st place in Poster Presentation at Annual Symposium of In vivo Center of Metabolism
  (2019-2019)
• Postdoctoral Fellowship from American Heart Association
  (2018-2020)
• Educational stipend from the International Society for Magnetic Resonance in Medicine
  (2017-2017)
• International Travel Award from Indian Council of Medical Research
  (2014)
• Educational stipend from the International Society for Magnetic Resonance in Medicine
  (2013-2013)
• Predoctoral Fellowships (Junior and Senior Research Fellowships) from Indian Council of Medical Research
  (2010-2015)

• American Association for the Advancement of Science (AAAS) (2016)
• American College of Cardiology (ACC) (2024)
• American Heart Association (AHA) (2018)
• American Physiological Society (APS) (2023)
• International Society for Heart and Lung Transplantation (ISHLT) (2022)
• International Society for Magnetic Resonance in Medicine (ISMRM) (2012)
• World Molecular Imaging Society (WMIC) (2013)