Abdallah Elnwasany, M.D.

Abdallah Elnwasany, M.D., is an Assistant Instructor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Cardiology.

Originally from Egypt, Dr. Elnwasany earned his medical degree from Alexandria University in Egypt. He completed his postdoctoral fellowship in the Division of Cardiology at UT Southwestern and joined the faculty in 2023.

Dr. Elnwasany's research is focused on cardiac metabolism, particularly in understanding the mechanisms by which insulin stimulates glucose utilization within the heart. Additionally, Dr. Elnwasany investigates the effects of dietary variations on both cardiac and mitochondrial metabolism and their impact on the development of insulin resistance and cardiovascular disease.

Medical School

(2016), Medicine

Featured Publications

Hypoxia-induced stabilization of HIF2A promotes cardiomyocyte proliferation by attenuating DNA damage

Shah R. Ali, Ngoc Uyen Nhi Nguyen, Ivan Menendez-Montes, Ching-Cheng Hsu, Waleed Elhelaly, Nicholas T. Lam, Shujuan Li, Abdallah Elnwasany, Yuji Nakada, Suwannee Thet, Roger S. Y. Foo, Hesham A. Sadek The Journal of Cardiovascular Aging 2024

Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development.

Cui M, Bezprozvannaya S, Hao T, Elnwasany A, Szweda LI, Liu N, Bassel-Duby R, Olson EN, Dev Cell 2023 Nov

Inhibition of Pyruvate Dehydrogenase in the Heart as an Initiating Event in the Development of Diabetic Cardiomyopathy.

Elnwasany A, Ewida HA, Szweda PA, Szweda LI, Antioxidants (Basel) 2023 Mar 12 3

PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.

Li Q, Li C, Elnwasany A, Sharma G, An YA, Zhang G, Elhelaly WM, Lin J, Gong Y, Chen G, Wang M, Zhao S, Dai C, Smart CD, Liu J, Luo X, Deng Y, Tan L, Lv SJ, Davidson SM, Locasale JW, Lorenzi PL, Malloy CR, Gillette TG, Vander Heiden MG, Scherer PE, Szweda LI, Fu G, Wang ZV, Circulation 2021 Aug 144 9 712-727

NAD⁺ Repletion Reverses Heart Failure With Preserved Ejection Fraction.

Tong D, Schiattarella GG, Jiang N, Altamirano F, Szweda PA, Elnwasany A, Lee DI, Yoo H, Kass DA, Szweda LI, Lavandero S, Verdin E, Gillette TG, Hill JA, Circ Res 2021 May 128 11 1629-1641

Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue.

Joffin N, Paschoal VA, Gliniak CM, Crewe C, Elnwasany A, Szweda LI, Zhang Q, Hepler C, Kusminski CM, Gordillo R, Oh DY, Gupta RK, Scherer PE, Cell Stem Cell 2021 Apr 28 4 702-717.e8

Angiocrine IGFBP3 Spatially Coordinates IGF Signaling During Neonatal Cardiac Regeneration

Shah R. Ali, Waleed Elhelaly, Ngoc Uyen Nhi Nguyen, Shujuan Li, Ivan Menendez-Montes, Zhaoning Wang, Miao Cui, Abdallah Elnwasany, Feng Xiao, Suwannee Thet, Nicholas T. Lam, Alisson Cardoso, Ana Helena Pereira, Mohammad Goodarzi, Michael T. Kinter, Andrew Lemoff, Luke I. Szweda, John Shelton, Wataru Kimura, Hesham A. Sadek 2021

Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression.

Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, Menendez-Montes I, Ensley EL, Petric UB, Sharma G, Sherry AD, Malloy CR, Khemtong C, Kinter MT, Tan WLW, Anene-Nzelu CG, Foo RS, Nguyen NUN, Li S, Ahmed MS, Elhelaly WM, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert KM, Mitsche MA, McDonald JG, Hill JA, Huang L, Shaul PW, Szweda LI, Sadek HA, Nat Metab 2020 Feb 2 2 167-178

C-Kit Cells Do Not Significantly Contribute to Cardiomyogenesis During Neonatal Heart Regeneration.

Elhelaly WM, Cardoso AC, Pereira AHM, Elnawasany A, Ebrahimi S, Nakada Y, Sadek HA, Circulation 2019 Jan 139 4 559-561

Coenzyme A-mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice.

Schafer C, Young ZT, Makarewich CA, Elnwasany A, Kinter C, Kinter M, Szweda LI, J Biol Chem 2018 May 293 18 6915-6924

• The Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center Trainee Fellowship
  (2022-2023)
• Ruth L. Kirschstein National Research Service Award, Department of Health and Human Services Public Health Service
  (2017-2019)
• Medical School Distinction Award, Alexandria University, Egypt
  (2004-2006)

• American Heart Association (2023)