Dr. Paul C. Sternweis received his Chemistry (summa cum laude) from the College of St. Thomas (St. Paul, MN.) and his Ph.D. in Biochemistry in 1977 with Dr. Leon Heppel at Cornell University (Ithaca, N.Y.). His graduate thesis focused on the elucidation of molecular mechanisms of the proton-translocating ATPase in Escherichia coli. As a postdoctoral fellow with Dr. Alfred Gilman, Dr. Sternweis began working on mammalian systems and contributed to the discovery, purification and characterization of the first G protein, Gs, that is responsible for hormonal regulation of adenylyl cyclase.

In 1982, Dr. Sternweis became an assistant professor of pharmacology at UT Southwestern, where he has risen to the rank of full professor and currently holds the Alfred and Mabel Gilman Chair in Molecular Pharmacology. During this time, Dr. Sternweis has continued to work on the mechanisms of hormonal signaling with a focus on G protein-dependent mechanisms including the identification of novel G proteins, regulation of phospholipases that produce lipid-derived second messengers and pathways that lead to the monomeric GTPases involved in cell architecture and movement.

Dr. Sternweis has served as Division Chair of the Molecular Pharmacology Division of ASPET and served on various grant review panels.  He chaired the Graduate Admissions committee for several years and coordinates the Signal Transduction course among other teaching responsibilities. He currently chairs the Cell Regulation graduate program.


University of St Thomas (1972), Chemistry
Graduate School
Cornell University (1977), Biochemistry

Research Interest

  • Fluorescent Sensors to measure in vivo activities
  • Integration of Hormone Signaling Pathways
  • Mechanisms of G protein-mediated Signaling
  • Regulation of Rho GTPases
  • Structures of Signaling Molecules


Featured Publications LegendFeatured Publications

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.
Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G Science 1998 Jun 280 5372 2112-4
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.
Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC Science 1998 Jun 280 5372 2109-11

Honors & Awards

  • Established Investigator
    American Heart Association (1986-1991)
  • Searle Scholar
  • Chair
    Alfred and Mabel Gilman Chair in Molecular Pharmacology, 2000-present (0)

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology
  • American Society for Pharmacology & Experimental Therapeutics