Madhu Manna, Ph.D.
Instructor
Department Pharmacology
Biography
Dr. Manna received his B.Sc. in Chemistry from Bajkul Milani Mahavidyalaya, West Bengal, India in 2008, and his M.Sc. in Chemistry from the Indian Institute of Technology, Guwahati, India in 2010. He earned his Ph.D. in Organic Chemistry from Indian Institute of Science, Bangalore, India in 2015 under the supervision of Dr. Santanu Mukherjee. His doctoral thesis was focused on construction of quaternary stereocenters using asymmetric organocatalysis. He worked as a Postdoctoral Fellow with Prof. Uttam Tambar and Dr. Erdal Toprak at University of Texas Southwestern Medical Center during 2016-2019. He is currently working as an Instructor in the Department of Pharmacology. His long-term research interest focuses on molecular recognition through noncovalent interactions, such as, hydrogen bonding, metal coordination, hydrophobic interactions, van der Waals forces, π-π stacking, etc. and their application on stereoselective synthesis of biologically relevant small molecules. Dr. Manna is currently working on understanding the molecular mechanism of antibiotic resistance and development of new generation antibiotics.
Research Interest
- Addressing ß-lactamase mediated antibiotic resistance problems
- Understanding the mechanism of antibiotic resistance
Publications
Featured Publications
- A trimethoprim derivative impedes antibiotic resistance evolution.
- Manna MS, Tamer YT, Gaszek I, Poulides N, Ahmed A, Wang X, Toprak FCR, Woodard DR, Koh AY, Williams NS, Borek D, Atilgan AR, Hulleman JD, Atilgan C, Tambar U, Toprak E, Nat Commun 2021 05 12 1 2949
- Nitro-enabled catalytic enantioselective formal umpolung alkenylation of ß-ketoesters.
- Choudhury AR, Manna MS, Mukherjee S, Chem Sci 2017 Sep 8 9 6686-6690
- Enantioselective Formal C(sp2 )-H Vinylation.
- Manna MS, Sarkar R, Mukherjee S, Chemistry 2016 Oct 22 42 14912-14919
- Organocatalytic enantioselective formal C(sp(2))-H alkylation.
- Manna MS, Mukherjee S, J. Am. Chem. Soc. 2015 Jan 137 1 130-3
- Catalytic asymmetric desymmetrization approaches to enantioenriched cyclopentanes.
- Manna MS, Mukherjee S, Org. Biomol. Chem. 2015 Jan 13 1 18-24
- Remarkable influence of secondary catalyst site on enantioselective desymmetrization of cyclopentenedione
- Manna MS, Mukherjee S, Chem. Sci. 2014 5 4 1627-1633
- Catalytic asymmetric direct vinylogous Michael addition of deconjugated butenolides to maleimides for the construction of quaternary stereogenic centers.
- Manna MS, Mukherjee S, Chemistry 2012 Nov 18 48 15277-82
- Catalytic enantioselective construction of quaternary stereocenters by direct vinylogous Michael addition of deconjugated butenolides to nitroolefins.
- Manna MS, Kumar V, Mukherjee S, Chem. Commun. (Camb.) 2012 May 48 42 5193-5