Dr. Wang conducted his early research in gene therapy at Fudan University in China. His Ph.D training at University of Massachusetts-Amherst led him to the direction of organelle biogenesis with focus on the molecular mechanism of chloroplast protein import in Arabidopsis thaliana. Then he adapted a powerful genetic and biochemical model system, yeast (saccharomyces cerevisiae), to dissect a post translational SRP/Sec61 independent ER membrane protein targeting pathway (GET pathway, guided-entry of tai-anchored protein insertion). He currently is working on revealing the role of Autophagy in cell development, aiming to understand the molecular mechanism. His studies will shed light directly on autophagy functions in eukaryotic gametogenesis, the production of sperm (spermatogenesis) and oocytes (oogenesis), and more broadly, on how the autophagic machinery rearranges membranes for crucial aspects of development. He is father of two kids and a Chinese poem writer.
- Cell Development and Aging
- Organelle Biogenesis
- Protein Trafficking and Targeting
- Autophagy of an amyloid-like translational repressor regulates meiotic exit.
- Wang F, Zhang R, Feng W, Tsuchiya D, Ballew O, Li J, Denic V, Lacefield S Dev Cell 2019 In Press
- The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.
- Wang F, Chan C, Weir NR, Denic V Nature 2014 Aug 512 7515 441-4
- The mechanism of tail-anchored protein insertion into the ER membrane.
- Wang F, Whynot A, Tung M, Denic V Mol. Cell 2011 Sep 43 5 738-50
- Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.
- Stefer S, Reitz S, Wang F, Wild K, Pang YY, Schwarz D, Bomke J, Hein C, Löhr F, Bernhard F, Denic V, Dötsch V, Sinning I Science 2011 Aug 333 6043 758-62
- Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33.
- Oreb M, Höfle A, Koenig P, Sommer MS, Sinning I, Wang F, Tews I, Schnell DJ, Schleiff E Biochem. J. 2011 Jun 436 2 313-9
- Energetic manipulation of chloroplast protein import and the use of chemical cross-linkers to map protein-protein interactions.
- Inoue H, Wang F, Inaba T, Schnell DJ Methods Mol. Biol. 2011 774 307-20
- A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum.
- Wang F, Brown EC, Mak G, Zhuang J, Denic V Mol. Cell 2010 Oct 40 1 159-71
- Toc receptor dimerization participates in the initiation of membrane translocation during protein import into chloroplasts.
- Lee J, Wang F, Schnell DJ J. Biol. Chem. 2009 Nov 284 45 31130-41
- A toc159 import receptor mutant, defective in hydrolysis of GTP, supports preprotein import into chloroplasts.
- Agne B, Infanger S, Wang F, Hofstetter V, Rahim G, Martin M, Lee DW, Hwang I, Schnell D, Kessler F J. Biol. Chem. 2009 Mar 284 13 8670-9
- The role of GTP binding and hydrolysis at the atToc159 preprotein receptor during protein import into chloroplasts.
- Wang F, Agne B, Kessler F, Schnell DJ J. Cell Biol. 2008 Oct 183 1 87-99
Honors & Awards
- Sara Elizabeth O'Brien Trust (Charles A. King Trust) Postdoctoral Fellowship
The Sara Elizabeth O'Brien Trust, Bank of America, N.A. (2013-2015)