Xiaochen Bai, Ph.D.

Undergraduate

Tsinghua University (2004), Mechanical Engineering

Graduate School

Tsinghua University (2011), Biophysics

• Membrane proteins that are critical for cellular signaling
• Receptor tyrosine kinase
• Single particle Cryo-EM
• Structural biology

Featured Publications

The Activation Mechanism of the Insulin Receptor: A Structural Perspective.

Choi E, Bai XC, Annu Rev Biochem 2023 Jun 92 247-272

Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex.

Xie T, Xu G, Liu Y, Quade B, Lin W, Bai XC, Proc Natl Acad Sci U S A 2023 Jun 120 23 e2300453120

Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor.

Wang L, Hall C, Li J, Choi E, Bai XC, Nat Struct Mol Biol 2023 May 30 5 661-669

Activation of the insulin receptor by an insulin mimetic peptide.

Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E, Nat Commun 2022 Sep 13 1 5594

Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors.

Cai K, Zhang X, Bai XC, Chem Rev 2022 Jun

Synergistic activation of the insulin receptor via two distinct sites.

Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC, Nat Struct Mol Biol 2022 Apr 29 4 357-368

Activation of STING by targeting a pocket in the transmembrane domain.

Lu D, Shang G, Li J, Lu Y, Bai XC, Zhang X, Nature 2022 04 604 7906 557-562

Structural basis of the activation of c-MET receptor.

Uchikawa E, Chen Z, Xiao GY, Zhang X, Bai XC, Nat Commun 2021 07 12 1 4074

Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing.

Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai XC, Rosenbaum DM, Cell 2021 Jun

Cryo-EM structure of the Hippo signaling integrator human STRIPAK.

Jeong BC, Bae SJ, Ni L, Zhang X, Bai XC, Luo X, Nat Struct Mol Biol 2021 03 28 3 290-299

 Featured Books

3D classification of structurally heterogeneous particles. In Single-particle Cryo-EM of Biological Macromolecules

(2021). IOP Publishing

• SCBA Young Investigators Award
  (2022)
• Amgen Young Investigators Award
  (2021)
• CPRIT scholar
  (2017)
• Virginia Murchison Linthicum Scholar in Medical Research, UT Southwestern Medical Center
  (2017)
• MRC CEO Award
  (2015)

• Department of Biophysics, University of Texas Southwestern Medical Center (2017)
• Department of Cell Biology, University of Texas Southwestern Medical Center (2017)