Xiaochen Bai, Ph.D. Titles and Appointments Professor Endowed Title Virginia Murchison Linthicum Scholar in Medical Research Schools Medical School | Graduate School Departments Biophysics | Cell Biology Graduate Programs Molecular Biophysics Education Undergraduate Tsinghua University (2004), Mechanical Engineering Graduate School Tsinghua University (2011), Biophysics Research Interest Insulin receptor, IGF1R Receptor tyrosine kinase Single particle Cryo-EM Structural biology Publications Featured Publications Insulin-like growth factor-binding protein 7 is a soluble cell adhesion molecule. Cai K, Zhang X, Bai XC, Sci Adv 2026 Aug 12 35 eaeg1148 Structural insights into the activation of the chicken ROS1 receptor by the NEL/NICOL ligand complex. An W, Zhang X, Bai XC, Nat Commun 2026 Feb Regulation of STING activation by phosphoinositide and cholesterol. Li J, Tan JX, Chen ZJ, Zhang X, Bai XC, Nature 2026 Feb Structure and activation of the Drosophila insulin receptor by three Drosophila insulin-like peptides. Cai K, Ng M, Yamamoto RR, Hossain MA, Hall C, Wade JD, Tatar M, Choi E, Bai XC, Nat Commun 2025 Oct 16 1 9504 Tuning insulin receptor signaling using de novo-designed agonists. Wang X, Cardoso S, Cai K, Venkatesh P, Hung A, Ng M, Hall C, Coventry B, Lee DS, Chowhan R, Gerben S, Li J, An W, Hon M, Gao M, Liao YC, Accili D, Choi E, Bai XC, Baker D, Mol Cell 2025 Oct Regulation and function of insulin and insulin-like growth factor receptor signalling. Choi E, Duan C, Bai XC, Nat Rev Mol Cell Biol 2025 Feb Activation of the insulin receptor by insulin-like growth factor 2. An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E, Nat Commun 2024 Mar 15 1 2609 Challenges and opportunities in macromolecular structure determination. Bai XC, Gonen T, Gronenborn AM, Perrakis A, Thorn A, Yang J, Nat Rev Mol Cell Biol 2023 Oct Activation of human STING by a molecular glue-like compound. Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y, Nat Chem Biol 2023 Oct Structural basis of insulin fibrillation. Wang L, Hall CE, Uchikawa E, Chen D, Choi E, Zhang X, Bai XC, Sci Adv 2023 Sep 9 37 eadi1057 Results 1-10 of 90 1 2 3 4 5 Next Last Books Featured Books 3D classification of structurally heterogeneous particles. In Single-particle Cryo-EM of Biological Macromolecules (2021). IOP Publishing Honors & Awards SCBA Young Investigators Award (2022) Amgen Young Investigators Award (2021) CPRIT scholar (2017) Virginia Murchison Linthicum Scholar in Medical Research, UT Southwestern Medical Center (2017) MRC CEO Award (2015) Professional Associations/Affiliations Department of Biophysics, University of Texas Southwestern Medical Center (2017) Department of Cell Biology, University of Texas Southwestern Medical Center (2017)
