Xiaochen Bai, Ph.D.

• Membrane proteins that are critical for cellular signaling
• Receptor tyrosine kinase
• Single particle Cryo-EM
• Structural biology

 Featured Publications

Activation of the insulin receptor by insulin-like growth factor 2.

An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E, Nat Commun 2024 Mar 15 1 2609

Challenges and opportunities in macromolecular structure determination.

Bai XC, Gonen T, Gronenborn AM, Perrakis A, Thorn A, Yang J, Nat Rev Mol Cell Biol 2023 Oct

Activation of human STING by a molecular glue-like compound.

Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y, Nat Chem Biol 2023 Oct

Structural basis of insulin fibrillation.

Wang L, Hall CE, Uchikawa E, Chen D, Choi E, Zhang X, Bai XC, Sci Adv 2023 Sep 9 37 eadi1057

The Activation Mechanism of the Insulin Receptor: A Structural Perspective.

Choi E, Bai XC, Annu Rev Biochem 2023 Jun 92 247-272

Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex.

Xie T, Xu G, Liu Y, Quade B, Lin W, Bai XC, Proc Natl Acad Sci U S A 2023 Jun 120 23 e2300453120

Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor.

Wang L, Hall C, Li J, Choi E, Bai XC, Nat Struct Mol Biol 2023 May 30 5 661-669

Activation of the insulin receptor by an insulin mimetic peptide.

Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E, Nat Commun 2022 Sep 13 1 5594

Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors.

Cai K, Zhang X, Bai XC, Chem Rev 2022 Jun

Synergistic activation of the insulin receptor via two distinct sites.

Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC, Nat Struct Mol Biol 2022 Apr 29 4 357-368

 Featured Books

 3D classification of structurally heterogeneous particles. In Single-particle Cryo-EM of Biological Macromolecules

(2021). IOP Publishing

• SCBA Young Investigators Award
  (2022)
• Amgen Young Investigators Award
  (2021)
• CPRIT scholar
  (2017)
• Virginia Murchison Linthicum Scholar in Medical Research, UT Southwestern Medical Center
  (2017)
• MRC CEO Award
  (2015)

• Department of Biophysics, University of Texas Southwestern Medical Center (2017)
• Department of Cell Biology, University of Texas Southwestern Medical Center (2017)