
Xiaochen Bai, Ph.D.
Associate Professor
Endowed Title Virginia Murchison Linthicum Scholar in Medical Research
School Medical School
Department Biophysics | Cell Biology
Graduate Programs Molecular Biophysics
Education
- Undergraduate
- Tsinghua University (2004), Mechanical Engineering
- Graduate School
- Tsinghua University (2011), Biophysics
Research Interest
- Membrane proteins that are critical for cellular signaling
- Receptor tyrosine kinase
- Single particle Cryo-EM
- Structural biology
Publications
Featured Publications
- The Activation Mechanism of the Insulin Receptor: A Structural Perspective.
- Choi E, Bai XC, Annu Rev Biochem 2023 Jun 92 247-272
- Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex.
- Xie T, Xu G, Liu Y, Quade B, Lin W, Bai XC, Proc Natl Acad Sci U S A 2023 Jun 120 23 e2300453120
- Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor.
- Wang L, Hall C, Li J, Choi E, Bai XC, Nat Struct Mol Biol 2023 May 30 5 661-669
- Activation of the insulin receptor by an insulin mimetic peptide.
- Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E, Nat Commun 2022 Sep 13 1 5594
- Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors.
- Cai K, Zhang X, Bai XC, Chem Rev 2022 Jun
- Synergistic activation of the insulin receptor via two distinct sites.
- Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC, Nat Struct Mol Biol 2022 Apr 29 4 357-368
- Activation of STING by targeting a pocket in the transmembrane domain.
- Lu D, Shang G, Li J, Lu Y, Bai XC, Zhang X, Nature 2022 04 604 7906 557-562
- Structural basis of the activation of c-MET receptor.
- Uchikawa E, Chen Z, Xiao GY, Zhang X, Bai XC, Nat Commun 2021 07 12 1 4074
- Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing.
- Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai XC, Rosenbaum DM, Cell 2021 Jun
- Cryo-EM structure of the Hippo signaling integrator human STRIPAK.
- Jeong BC, Bae SJ, Ni L, Zhang X, Bai XC, Luo X, Nat Struct Mol Biol 2021 03 28 3 290-299
Books
Featured Books
3D classification of structurally heterogeneous particles. In Single-particle Cryo-EM of Biological Macromolecules
(2021). IOP Publishing
Honors & Awards
- SCBA Young Investigators Award
(2022) - Amgen Young Investigators Award
(2021) - CPRIT scholar
(2017) - Virginia Murchison Linthicum Scholar in Medical Research, UT Southwestern Medical Center
(2017) - MRC CEO Award
(2015)
Professional Associations/Affiliations
- Department of Biophysics, University of Texas Southwestern Medical Center (2017)
- Department of Cell Biology, University of Texas Southwestern Medical Center (2017)