Xiaochen Bai, Ph.D. Titles and Appointments Associate Professor Endowed Title Virginia Murchison Linthicum Scholar in Medical Research School Medical School Department Biophysics | Cell Biology Graduate Programs Molecular Biophysics Education Undergraduate Tsinghua University (2004), Mechanical Engineering Graduate School Tsinghua University (2011), Biophysics Research Interest Insulin receptor, IGF1R Receptor tyrosine kinase Single particle Cryo-EM Structural biology Publications Featured Publications Regulation and function of insulin and insulin-like growth factor receptor signalling. Choi E, Duan C, Bai XC, Nat Rev Mol Cell Biol 2025 Feb Activation of the insulin receptor by insulin-like growth factor 2. An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E, Nat Commun 2024 Mar 15 1 2609 Challenges and opportunities in macromolecular structure determination. Bai XC, Gonen T, Gronenborn AM, Perrakis A, Thorn A, Yang J, Nat Rev Mol Cell Biol 2023 Oct Activation of human STING by a molecular glue-like compound. Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y, Nat Chem Biol 2023 Oct Structural basis of insulin fibrillation. Wang L, Hall CE, Uchikawa E, Chen D, Choi E, Zhang X, Bai XC, Sci Adv 2023 Sep 9 37 eadi1057 The Activation Mechanism of the Insulin Receptor: A Structural Perspective. Choi E, Bai XC, Annu Rev Biochem 2023 Jun 92 247-272 Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex. Xie T, Xu G, Liu Y, Quade B, Lin W, Bai XC, Proc Natl Acad Sci U S A 2023 Jun 120 23 e2300453120 Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor. Wang L, Hall C, Li J, Choi E, Bai XC, Nat Struct Mol Biol 2023 May 30 5 661-669 Activation of the insulin receptor by an insulin mimetic peptide. Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E, Nat Commun 2022 Sep 13 1 5594 Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors. Cai K, Zhang X, Bai XC, Chem Rev 2022 Jun Results 1-10 of 78 1 2 3 4 5 Next Last Books Featured Books 3D classification of structurally heterogeneous particles. In Single-particle Cryo-EM of Biological Macromolecules (2021). IOP Publishing Honors & Awards SCBA Young Investigators Award (2022) Amgen Young Investigators Award (2021) CPRIT scholar (2017) Virginia Murchison Linthicum Scholar in Medical Research, UT Southwestern Medical Center (2017) MRC CEO Award (2015) Professional Associations/Affiliations Department of Biophysics, University of Texas Southwestern Medical Center (2017) Department of Cell Biology, University of Texas Southwestern Medical Center (2017)
