Xiaochen Bai, Ph.D.

Undergraduate

Tsinghua University (2004), Mechanical Engineering

Graduate School

Tsinghua University (2011), Biophysics

• Membrane proteins that are critical for cellular signaling
• Receptor tyrosine kinase
• Single particle Cryo-EM
• Structural biology

Featured Publications

Synergistic activation of the insulin receptor via two distinct sites.

Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC, Nat Struct Mol Biol 2022 Apr 29 4 357-368

Activation of STING by targeting a pocket in the transmembrane domain.

Lu D, Shang G, Li J, Lu Y, Bai XC, Zhang X, Nature 2022 04 604 7906 557-562

Structural basis of the activation of c-MET receptor.

Uchikawa E, Chen Z, Xiao GY, Zhang X, Bai XC, Nat Commun 2021 07 12 1 4074

Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing.

Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai XC, Rosenbaum DM, Cell 2021 Jun

Cryo-EM structure of the Hippo signaling integrator human STRIPAK.

Jeong BC, Bae SJ, Ni L, Zhang X, Bai XC, Luo X, Nat Struct Mol Biol 2021 03 28 3 290-299

Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations.

Xue J, Xie T, Zeng W, Jiang Y, Bai XC, Elife 2020 Jul 9

Cryo-EM structure of the human cohesin-NIPBL-DNA complex.

Shi Z, Gao H, Bai XC, Yu H, Science 2020 06 368 6498 1454-1459

Structural basis of the activation of type 1 insulin-like growth factor receptor.

Li J, Choi E, Yu H, Bai XC, Nat Commun 2019 Oct 10 1 4567

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.

Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC, Elife 2019 Sep 8

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.

Uchikawa E, Choi E, Shang G, Yu H, Bai XC, Elife 2019 Aug 8

 Featured Books

3D classification of structurally heterogeneous particles. In Single-particle Cryo-EM of Biological Macromolecules

(2021). IOP Publishing

• CPRIT scholar
  (2017)
• Virginia Murchison Linthicum Scholar in Medical Research, UT Southwestern Medical Center
  (2017)

• Department of Biophysics, University of Texas Southwestern Medical Center (2017)
• Department of Cell Biology, University of Texas Southwestern Medical Center (2017)