In 2006, Dr. Cantarel received a Ph.D. in Biochemistry in the Structural and Computational Biology, Biophysics program from the University of Virginia. She spent one year as a postdoctoral fellow in the Department of Human Genetics at the University of Utah, where she was part of the team that developed MAKER, a eukaryotic genome annotation package. Then she spent two years as a postdoctoral fellow at the CNRS in Marseille, France. While in France, she began to work in an emerging field of metagenomics while developing new tools for carbohydrate-active enzyme gene classification.
In 2009, she moved to the University of Maryland, School of Medicine’s Institute for Genome Science, starting out as a bioinformatics analyst before joining the faculty on the research track. Because the University of Maryland was the Data Analysis and Coordination Center for the Human Microbiome Project (http://www.hmpdacc.org), Dr Cantarel acted as a scientific coordinator for the project and chaired the genes of interest committee, in addition to leading the data analysis for a number of heath-association projects and characterizing the carbohydrate-active enzymes in the various body sites of the human body.
In 2013, she moved to Baylor Research Institute at Baylor Scott and White in Dallas, TX. With a new next-generation sequencing core, Dr. Cantarel led the effort to bring NGS analysis to the bioinformatics core and participated in a number of immunological studies. With some colleagues from UVA, she was part of the team to develop BAYSIC, a variant integration tool.
Finally, in November 2015, Dr. Cantarel joined UTSW. She is interested in (i) developing the tools to make data analysis easier for researchers, (ii) coordinating classes to train students and post-doc in sequence analysis, and (iii) participate in large-scale sequence analysis projects. Dr. Cantarel is a key member of the Program for Human Genomics team involving researchers in pathology, immunology, and bioinformatics. The goal of this group is to develop next-generation sequence assays for use in the clinic. The NGS assays in developing include: tumor mutation profiling using a 1385 Gene Panel, Whole Exome for patients and HLA-testing. Because of the prospect of "big data", Dr. Cantarel is interesting in (i) improvement of variation detection methods and (ii) identification of novel biomarkers in cancer and rare disease.
- Graduate School
- University of Virginia Main Ca (2006), Biology
- Animal Associated Microbiome; Bacterial Genomics;
- Cancer Genomics
- Eukaryotic Genomics
- Next Generation Sequence (NGS) Analysis;; Whole Genome/Exome Variant Analysis; Transcriptomics; Epigenomics
- Protein Evolution
- Obligate biotrophy features unraveled by the genomic analysis of rust fungi.
- Duplessis S, Cuomo CA, Lin YC, Aerts A, Tisserant E, Veneault-Fourrey C, Joly DL, Hacquard S, Amselem J, Cantarel BL, Chiu R, Coutinho PM, Feau N, Field M, Frey P, Gelhaye E, Goldberg J, Grabherr MG, Kodira CD, Kohler A, Kües U, Lindquist EA, Lucas SM, Mago R, Mauceli E, Morin E, Murat C, Pangilinan JL, Park R, Pearson M, Quesneville H, Rouhier N, Sakthikumar S, Salamov AA, Schmutz J, Selles B, Shapiro H, Tanguay P, Tuskan GA, Henrissat B, Van de Peer Y, Rouzé P, Ellis JG, Dodds PN, Schein JE, Zhong S, Hamelin RC, Grigoriev IV, Szabo LJ, Martin F Proc. Natl. Acad. Sci. U.S.A. 2011 May 108 22 9166-71
- Strategies for metagenomic-guided whole-community proteomics of complex microbial environments.
- Cantarel BL, Erickson AR, VerBerkmoes NC, Erickson BK, Carey PA, Pan C, Shah M, Mongodin EF, Jansson JK, Fraser-Liggett CM, Hettich RL PLoS ONE 2011 6 11 e27173
- Functional metagenomics to mine the human gut microbiome for dietary fiber catabolic enzymes.
- Tasse L, Bercovici J, Pizzut-Serin S, Robe P, Tap J, Klopp C, Cantarel BL, Coutinho PM, Henrissat B, Leclerc M, Doré J, Monsan P, Remaud-Simeon M, Potocki-Veronese G Genome Res. 2010 Nov 20 11 1605-12
- Périgord black truffle genome uncovers evolutionary origins and mechanisms of symbiosis.
- Martin F, Kohler A, Murat C, Balestrini R, Coutinho PM, Jaillon O, Montanini B, Morin E, Noel B, Percudani R, Porcel B, Rubini A, Amicucci A, Amselem J, Anthouard V, Arcioni S, Artiguenave F, Aury JM, Ballario P, Bolchi A, Brenna A, Brun A, Buée M, Cantarel B, Chevalier G, Couloux A, Da Silva C, Denoeud F, Duplessis S, Ghignone S, Hilselberger B, Iotti M, Marçais B, Mello A, Miranda M, Pacioni G, Quesneville H, Riccioni C, Ruotolo R, Splivallo R, Stocchi V, Tisserant E, Viscomi AR, Zambonelli A, Zampieri E, Henrissat B, Lebrun MH, Paolocci F, Bonfante P, Ottonello S, Wincker P Nature 2010 Apr 464 7291 1033-8
- Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla.
- Mahowald MA, Rey FE, Seedorf H, Turnbaugh PJ, Fulton RS, Wollam A, Shah N, Wang C, Magrini V, Wilson RK, Cantarel BL, Coutinho PM, Henrissat B, Crock LW, Russell A, Verberkmoes NC, Hettich RL, Gordon JI Proc. Natl. Acad. Sci. U.S.A. 2009 Apr 106 14 5859-64
- A core gut microbiome in obese and lean twins.
- Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI Nature 2009 Jan 457 7228 480-4
- nGASP--the nematode genome annotation assessment project.
- Coghlan A, Fiedler TJ, McKay SJ, Flicek P, Harris TW, Blasiar D, Stein LD BMC Bioinformatics 2008 Dec 9 549
- The convergence of carbohydrate active gene repertoires in human gut microbes.
- Lozupone CA, Hamady M, Cantarel BL, Coutinho PM, Henrissat B, Gordon JI, Knight R Proc. Natl. Acad. Sci. U.S.A. 2008 Sep 105 39 15076-81
- Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.
- Sun X, Frierson HF, Chen C, Li C, Ran Q, Otto KB, Cantarel BL, Cantarel BM, Vessella RL, Gao AC, Petros J, Miura Y, Simons JW, Dong JT Nat. Genet. 2005 Apr 37 4 407-12
The Carbohydrate-Active Enzymes Database (CAZy): A Metagenomic Expert Resource for Glycobiological Inference. In Encyclopedia of Metagenomics
Cantarel BL, Coutinho PM, Henrissat B. (2012). New York, NY, SpringerReference