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Rodrigo Zepeda, M.D., is an Assistant Professor of Neurology at UT Southwestern Medical Center. As an epilepsy specialist, he works with the epilepsy team at UT Southwestern to diagnose and treat patients who suffer from seizures. Dr. Zepeda also serves as the Program Director of the Clinical Neurophysiology Fellowship Program.

Dr. Zepeda earned his medical degree with honors at the Tecnológico de Monterrey School of Medicine in Mexico.  After graduating from medical school, Dr. Zepeda spent almost a year providing medical care for marginalized communities in Chiapas, Mexico working for Partners in Health, a Boston-based global health nonprofit. He then completed his internal medicine internship, neurology residency and epilepsy fellowship at Harvard Medical School, Brigham and Women’s Hospital, and Massachusetts General Hospital. During this time, he also joined the Bhutan Epilepsy Project, which used portable EEG diagnostic equipment to accurately diagnose patients suffering from seizures in Bhutan, located in the Eastern Himalayas.

Dr. Zepeda's research interests include the management of refractory epilepsy, ICU EEG and global health.


Medical School
Tecnologico de Monterrey Escuela de Medicina Ignacio A. Santos (2009)
Research Fellowship
Massachusetts General Hospital (2010), Neurophysiology
Harvard/Brigham and Women's Hospital (2011), Internal Medicine
Massachusetts General Hospital & Brigham and Women's Hospital (2014), Neurology
Massachusetts General Hospital (2016), Epilepsy/clinical Neurophysiology

Research Interest

  • Epilepsy Surgery


Stereo-electroencephalographic seizure localization in patients with mesial temporal sclerosis: A single center experience
Zhang B, Podkorytova I, Hays R, Perven G, Agostini M, Harvey J, Zepeda R, Alick-Lindstrom S, Dieppa M, Doyle A, Das R, Lega B, Ding K Clinical Neurophysiology Practice 2024 Jan 9 106-111
Emergency department visits and readmissions in patients with psychogenic nonepileptic seizures (PNES) at a safety net hospital
Ramamurthy S, Steven Brown L, Agostini M, Alick Lindstorm S, Dave H, Dieppa M, Ding K, Doyle A, Hays R, Harvey J, Perven G, Podkorytova I, Zepeda R, Das RR Epilepsy and Behavior 2021 Sep 122
Non-lesional mesial temporal lobe epilepsy requires bilateral invasive evaluation
Perven G, Podkorytova I, Ding K, Agostini M, Alick S, Das R, Dave H, Dieppa M, Doyle A, Harvey J, Lega B, Zepeda R, Hays R Epilepsy and Behavior Reports 2021 Jan 15
Emergent Admissions to the Epilepsy Monitoring Unit in the Setting of COVID-19 Pandemic-related, State-mandated Restrictions: Clinical Decision Making and Outcomes
Zepeda R, Lee Y, Agostini M, Alick Lindstrom S, Dave H, Dieppa M, Ding K, Doyle A, Harvey J, Hays R, Perven G, Podkorytova I, Das RR Neurodiagnostic Journal 2021 61 95-103
Association of epileptiform abnormalities and seizures in Alzheimer disease
Lam AD, Sarkis RA, Pellerin KR, Jing J, Dworetzky BA, Hoch DB, Jacobs CS, Lee JW, Weisholtz DS, Zepeda R, Westover MB, Cole AJ, Cash SS Neurology 2020 Oct 95 E2259-E2270
Widespread changes in network activity allow non-invasive detection of mesial temporal lobe seizures
Lam AD, Zepeda R, Cole AJ, Cash SS Brain 2016 Oct 139 2679-2693
Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan
McKenzie ED, Nirola DK, Deki S, Tshering L, Patenaude B, Clark SJ, Cash SS, Thibert R, Zepeda R, Leung EC, Lam AD, Lim AS, Mantia J, Cohen J, Cole AJ, Mateen FJ Epilepsy and Behavior 2016 Jun 59 122-127
Hearing loss in Wernicke encephalopathy
Walker MA, Zepeda R, Afari HA, Cohen AB Neurology: Clinical Practice 2014 4 511-515
Individualized localization and cortical surface-based registration of intracranial electrodes
Dykstra AR, Chan AM, Quinn BT, Zepeda R, Keller CJ, Cormier J, Madsen JR, Eskandar EN, Cash SS NeuroImage 2012 Feb 59 3563-3570
Graphical models for localization of the seizure focus from interictal intracranial EEG
Dauwels J, Eskandar E, Cole A, Hoch D, Zepeda R, Cash SS 2011 745-748


Featured Books Legend Featured Books

Bell´s Palsy. In Pocket Primary Care

Meghan M. Kiefer, Curtis R. Chong (2014). Lippincott Williams & Wilkins

Seizures, Epilepsy and EEG. In Pocket Neurology

Brandon Westover, Matthew Bianchi (2010). Lippincott Williams & Wilkins

Seizures. In Pocket Primary Care

Meghan M. Kiefer, Curtis R. Chong (2014). Lippincott Williams & Wilkins

Honors & Awards

  • Brigham & Women’s Hospital Dunne Award for Outstanding Compassionate Care

Professional Associations/Affiliations

  • University of Texas Southwestern Medical Center (2016)