Biography

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Dr. Shaul received his B.A. from Dartmouth College and his M.D. from the University of Cincinnati. He received residency training in pediatrics at the Children's Medical Center of Cincinnati/University of Cincinnati followed by fellowship training in neonatal-perinatal medicine at Women and Infant's Hospital of Rhode Island/Brown University.

He joined the faculty of the University of Texas Southwestern Medical Center in 1986, and is the holder of the Associates First Capitol Corporation Distinguished Chair in Pediatrics at UT Southwestern. He is the Director of the Center for Pulmonary and Vascular Biology and Vice Chair for Research in the Department of Pediatrics, and a member of the Integrative Biology Graduate Program in the Division of Basic Science. Dr. Shaul was President of the Society for Pediatric Research in 2005-2006.

Education

Medical School
University of Cincinnati College of Medicine (1981)
Residency
Children's Hospital Medical Center -Cincinnati (1984), Pediatrics
Fellowship
Brown University Medical School (1986), Neonatal-perinatal Medicine

Research Interest

  • apolipoprotein E receptor 2 (LRP8)
  • Caveolae, lipid rafts
  • Fc receptors and cardiometabolic disorders
  • Membrane-associated estrogen receptors
  • Nitric oxide synthase
  • Scavenger receptor class B, type I (HDL receptor)
  • Vascular basis of type 2 diabetes

Publications

Featured Publications LegendFeatured Publications

HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events.
Rohatgi A, Khera A, Berry JD, Givens EG, Ayers CR, Wedin KE, Neeland IJ, Yuhanna IS, Rader DR, de Lemos JA, Shaul PW N. Engl. J. Med. 2014 Nov
IgG Receptor Fc?RIIB Plays a Key Role in Obesity-Induced Hypertension.
Sundgren NC, Vongpatanasin W, Boggan BM, Tanigaki K, Yuhanna IS, Chambliss KL, Mineo C, Shaul PW Hypertension 2014 Nov
Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice.
Ulrich V, Konaniah ES, Lee WR, Khadka S, Shen YM, Herz J, Salmon JE, Hui DY, Shaul PW, Mineo C J Am Heart Assoc 2014 Oct 3 5 e001369
Genetic variants of ApoE and ApoER2 differentially modulate endothelial function.
Ulrich V, Konaniah ES, Herz J, Gerard RD, Jung E, Yuhanna IS, Ahmed M, Hui DY, Mineo C, Shaul PW Proc. Natl. Acad. Sci. U.S.A. 2014 Sep 111 37 13493-8
The Cholesterol Metabolite 27-Hydroxycholesterol Promotes Atherosclerosis via Proinflammatory Processes Mediated by Estrogen Receptor Alpha.
Umetani M, Ghosh P, Ishikawa T, Umetani J, Ahmed M, Mineo C, Shaul PW Cell Metab. 2014 Jun
Bazedoxifene and Conjugated Estrogen Prevent Diet-induced Obesity, Hepatic Steatosis and Type 2 Diabetes in Mice Without Impacting the Reproductive Tract.
Barrera J, Chambliss KL, Ahmed M, Tanigaki K, Thompson B, McDonald JG, Mineo C, Shaul PW Am. J. Physiol. Endocrinol. Metab. 2014 Jun
Mutation of the palmitoylation site of estrogen receptor a in vivo reveals tissue-specific roles for membrane versus nuclear actions.
Adlanmerini M, Solinhac R, Abot A, Fabre A, Raymond-Letron I, Guihot AL, Boudou F, Sautier L, Vessières E, Kim SH, Lière P, Fontaine C, Krust A, Chambon P, Katzenellenbogen JA, Gourdy P, Shaul PW, Henrion D, Arnal JF, Lenfant F Proc. Natl. Acad. Sci. U.S.A. 2014 Jan 111 2 E283-90
Recent insights into non-nuclear actions of estrogen receptor alpha.
Banerjee S, Chambliss KL, Mineo C, Shaul PW Steroids 2013 Nov
Regulation of Signal Transduction by HDL.
Mineo C, Shaul PW J. Lipid Res. 2013 May
C-Reactive Protein Causes Insulin Resistance in Mice Through Fc? Receptor IIB-Mediated Inhibition of Skeletal Muscle Glucose Delivery.
Tanigaki K, Vongpatanasin W, Barrera JA, Atochin DN, Huang PL, Bonvini E, Shaul PW, Mineo C Diabetes 2013 Mar 62 3 721-31

Books

Featured Books Legend Featured Books

Honors & Awards

  • Association of American Physicians
    (2013)
  • Associates First Capitol Corporation Distinguished Chair in Pediatrics
    (2011)
  • Hall of Honor, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
    (2010)
  • President, Society for Pediatric Research
    (2005-2006)
  • Codirector, Crystal Charity Ball Center for Research in Pediatric Critical Care
    (1997)
  • Lowe Foundation Professorship in Pediatric Critical Care Research
    (1997-2011)
  • Established Investigator Award, AHA
    (1993)

Professional Associations/Affiliations

  • Association of American Physicians (2013)
  • American Pediatric Society (2003)
  • American Society for Clinical Investigation (1999)
  • The American Physiological Society (1999)
  • Perinatal Research Society (1992-2013)
  • Society for Pediatric Research (1990)
  • American Academy of Pediatrics, Fellow (1987)
  • Dallas County Medical Society (1987)