Biography

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Dr. Shaul received his B.A. from Dartmouth College and his M.D. from the University of Cincinnati. He received residency training in pediatrics at the Children's Medical Center of Cincinnati/University of Cincinnati followed by fellowship training in neonatal-perinatal medicine at Women and Infant's Hospital of Rhode Island/Brown University.

He joined the faculty of the University of Texas Southwestern Medical Center in 1986, and is the holder of the Associates First Capitol Corporation Distinguished Chair in Pediatrics at UT Southwestern. He is the Director of the Center for Pulmonary and Vascular Biology and Vice Chair for Research in the Department of Pediatrics, and a member of the Integrative Biology Graduate Program in the Division of Basic Science. Dr. Shaul was President of the Society for Pediatric Research in 2005-2006.

Education

Medical School
University of Cincinnati College of Medicine (1981)
Residency
Children's Hospital Medical Center -Cincinnati (1984), Pediatrics
Fellowship
Brown University Medical School (1986), Neonatal-perinatal Medicine

Research Interest

  • apolipoprotein E receptor 2 (LRP8)
  • Caveolae, lipid rafts
  • Fc receptors and cardiometabolic disorders
  • Membrane-associated estrogen receptors
  • Nitric oxide synthase
  • Scavenger receptor class B, type I (HDL receptor)
  • Vascular basis of type 2 diabetes

Publications

Featured Publications LegendFeatured Publications

Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.
Mineo C, Lanier L, Jung E, Sengupta S, Ulrich V, Sacharidou A, Tarango C, Osunbunmi O, Shen YM, Salmon JE, Brekken RA, Huang X, Thorpe PE, Shaul PW PLoS ONE 2016 11 7 e0158757
Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation.
Ding Y, Huang L, Xian X, Yuhanna IS, Wasser CR, Frotscher M, Mineo C, Shaul PW, Herz J Sci Signal 2016 9 419 ra29
Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues.
Madak-Erdogan Z, Kim SH, Gong P, Zhao YC, Zhang H, Chambliss KL, Carlson KE, Mayne CG, Shaul PW, Korach KS, Katzenellenbogen JA, Katzenellenbogen BS Sci Signal 2016 9 429 ra53
ApoE Receptor 2 mediates trophoblast dysfunction and pregnancy complications induced by antiphospholipid antibodies in mice.
Ulrich V, Gelber SE, Vukelic M, Sacharidou A, Herz J, Urbanus RT, de Groot PG, Natale DR, Harihara A, Redecha P, Abrahams VM, Shaul PW, Salmon JE, Mineo C Arthritis & rheumatology (Hoboken, N.J.) 2015 Oct
A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.
Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC Mol. Cell 2015 Jun 58 5 845-53
HDL cholesterol efflux capacity and cardiovascular events.
Rohatgi A, de Lemos JA, Shaul PW N. Engl. J. Med. 2015 May 372 19 1871-2
Inhibition of ATP-Binding Cassette Transporter A1 Protein Degradation Promotes HDL Cholesterol Efflux Capacity and Reverse Cholesterol Transport and Reduces Atherosclerosis in Mice.
Huang L, Fan BY, Ma A, Shaul PW, Zhu H J. Lipid Res. 2015 Mar
Fc? Receptors and Ligands and Cardiovascular Disease.
Tanigaki K, Sundgren N, Khera A, Vongpatanasin W, Mineo C, Shaul PW Circ. Res. 2015 Jan 116 2 368-384
Role of the endothelium in the metabolic syndrome: IIb or not IIb.
Shaul PW Am. J. Med. Sci. 2015 Jan 349 1 3-5
PDZK1 Prevents Neointima Formation via Suppression of Breakpoint Cluster Region Kinase in Vascular Smooth Muscle.
Lee WR, Sacharidou A, Behling-Kelly E, Oltmann SC, Zhu W, Ahmed M, Gerard RD, Hui DY, Abe J, Shaul PW, Mineo C PLoS ONE 2015 10 4 e0124494

Books

Featured Books Legend Featured Books

Honors & Awards

  • Association of American Physicians
    (2013)
  • Associates First Capitol Corporation Distinguished Chair in Pediatrics
    (2011)
  • Hall of Honor, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
    (2010)
  • President, Society for Pediatric Research
    (2005-2006)
  • Codirector, Crystal Charity Ball Center for Research in Pediatric Critical Care
    (1997)
  • Lowe Foundation Professorship in Pediatric Critical Care Research
    (1997-2011)
  • Established Investigator Award, AHA
    (1993)

Professional Associations/Affiliations

  • Association of American Physicians (2013)
  • American Pediatric Society (2003)
  • American Society for Clinical Investigation (1999)
  • The American Physiological Society (1999)
  • Perinatal Research Society (1992-2013)
  • Society for Pediatric Research (1990)
  • American Academy of Pediatrics, Fellow (1987)
  • Dallas County Medical Society (1987)