Dr. Shaul received his B.A. from Dartmouth College and his M.D. from the University of Cincinnati. He received residency training in pediatrics at the Children's Medical Center of Cincinnati/University of Cincinnati followed by fellowship training in neonatal-perinatal medicine at Women and Infant's Hospital of Rhode Island/Brown University.
He joined the faculty of the University of Texas Southwestern Medical Center in 1986, and is the holder of the Associates First Capitol Corporation Distinguished Chair in Pediatrics at UT Southwestern. He is the Director of the Center for Pulmonary and Vascular Biology and Vice Chair for Research in the Department of Pediatrics, and a member of the Integrative Biology Graduate Program in the Division of Basic Science. Dr. Shaul was President of the Society for Pediatric Research in 2005-2006.
- Medical School
- University of Cincinnati College of Medicine (1981)
- Children's Hospital Medical Center -Cincinnati (1984), Pediatrics
- Brown University Medical School (1986), Neonatal-perinatal Medicine
- apolipoprotein E receptor 2 (LRP8)
- Caveolae, lipid rafts
- Fc receptors and cardiometabolic disorders
- Membrane-associated estrogen receptors
- Nitric oxide synthase
- Scavenger receptor class B, type I (HDL receptor)
- Vascular basis of type 2 diabetes
- Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.
- Mineo C, Lanier L, Jung E, Sengupta S, Ulrich V, Sacharidou A, Tarango C, Osunbunmi O, Shen YM, Salmon JE, Brekken RA, Huang X, Thorpe PE, Shaul PW PLoS ONE 2016 11 7 e0158757
- Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation.
- Ding Y, Huang L, Xian X, Yuhanna IS, Wasser CR, Frotscher M, Mineo C, Shaul PW, Herz J Sci Signal 2016 9 419 ra29
- Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues.
- Madak-Erdogan Z, Kim SH, Gong P, Zhao YC, Zhang H, Chambliss KL, Carlson KE, Mayne CG, Shaul PW, Korach KS, Katzenellenbogen JA, Katzenellenbogen BS Sci Signal 2016 9 429 ra53
- ApoE Receptor 2 mediates trophoblast dysfunction and pregnancy complications induced by antiphospholipid antibodies in mice.
- Ulrich V, Gelber SE, Vukelic M, Sacharidou A, Herz J, Urbanus RT, de Groot PG, Natale DR, Harihara A, Redecha P, Abrahams VM, Shaul PW, Salmon JE, Mineo C Arthritis & rheumatology (Hoboken, N.J.) 2015 Oct
- A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.
- Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC Mol. Cell 2015 Jun 58 5 845-53
- HDL cholesterol efflux capacity and cardiovascular events.
- Rohatgi A, de Lemos JA, Shaul PW N. Engl. J. Med. 2015 May 372 19 1871-2
- Inhibition of ATP-Binding Cassette Transporter A1 Protein Degradation Promotes HDL Cholesterol Efflux Capacity and Reverse Cholesterol Transport and Reduces Atherosclerosis in Mice.
- Huang L, Fan BY, Ma A, Shaul PW, Zhu H J. Lipid Res. 2015 Mar
- Fc? Receptors and Ligands and Cardiovascular Disease.
- Tanigaki K, Sundgren N, Khera A, Vongpatanasin W, Mineo C, Shaul PW Circ. Res. 2015 Jan 116 2 368-384
- Role of the endothelium in the metabolic syndrome: IIb or not IIb.
- Shaul PW Am. J. Med. Sci. 2015 Jan 349 1 3-5
- PDZK1 Prevents Neointima Formation via Suppression of Breakpoint Cluster Region Kinase in Vascular Smooth Muscle.
- Lee WR, Sacharidou A, Behling-Kelly E, Oltmann SC, Zhu W, Ahmed M, Gerard RD, Hui DY, Abe J, Shaul PW, Mineo C PLoS ONE 2015 10 4 e0124494
Physiology of Nitric Oxide in the Developing Lung. In Polin RA, Fox WW, Abman SH, eds. Fetal and Neonatal Physiology. 4th ed.
Kinsella JP, Shaul PW. (2011). Philadelphia: Elsevier Saunders; 807-820.
Pulmonary Hypertension Syndromes. In Levin DL, Morriss FC, eds. Essentials of Pediatric Intensive Care. Vol 2.
Zellers TM, Shaul PW. (1997). Churchill Livingstone; 188-195.
Regulation of eNOS in Caveolae. In Jasmin J, Frank P, Lisanti MP, eds. Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms.
Mineo C, Shaul PW. (2012.). New York: Springer; 51-62.
Caveolae and Estrogen Receptor Signaling. In Lisanti ML, Frank PG, eds. Advances in Molecular and Cell Biology Series. Vol 36.
Shaul PW, Chambliss KL. (2005). Elsevier; 109-123.
Regulation of Endothelial NO Synthase Activity by Estrogen Receptors in a Steroid Receptor Fast-Action Complex (SRFC) In Caveolae. In Watson CS, ed. The Identities of Membrane Steroid Receptors.
Shaul PW, Chambliss KL, Mineo C. (2003). Norwell, MA: Kluwer Academic Publishers; 27-36.
Honors & Awards
- Association of American Physicians
- Associates First Capitol Corporation Distinguished Chair in Pediatrics
- Hall of Honor, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
- President, Society for Pediatric Research
- Codirector, Crystal Charity Ball Center for Research in Pediatric Critical Care
- Lowe Foundation Professorship in Pediatric Critical Care Research
- Established Investigator Award, AHA
- Association of American Physicians (2013)
- American Pediatric Society (2003)
- American Society for Clinical Investigation (1999)
- The American Physiological Society (1999)
- Perinatal Research Society (1992-2013)
- Society for Pediatric Research (1990)
- American Academy of Pediatrics, Fellow (1987)
- Dallas County Medical Society (1987)