Biography

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Dr. Shaul received his B.A. from Dartmouth College and his M.D. from the University of Cincinnati. He received residency training in pediatrics at the Children's Medical Center of Cincinnati/University of Cincinnati followed by fellowship training in neonatal-perinatal medicine at Women and Infant's Hospital of Rhode Island/Brown University.

He joined the faculty of the University of Texas Southwestern Medical Center in 1986, and is the holder of the Associates First Capitol Corporation Distinguished Chair in Pediatrics at UT Southwestern. He is the Director of the Center for Pulmonary and Vascular Biology and Vice Chair for Research in the Department of Pediatrics, and a member of the Integrative Biology Graduate Program in the Division of Basic Science. Dr. Shaul was President of the Society for Pediatric Research in 2005-2006.

Education

Medical School
University of Cincinnati College of Medicine (1981)
Residency
Children's Hospital Medical Center -Cincinnati (1984), Pediatrics
Fellowship
Brown University Medical School (1986), Neonatal-perinatal Medicine

Research Interest

  • apolipoprotein E receptor 2 (LRP8)
  • Caveolae, lipid rafts
  • Fc receptors and cardiometabolic disorders
  • Membrane-associated estrogen receptors
  • Nitric oxide synthase
  • Scavenger receptor class B, type I (HDL receptor)
  • Vascular basis of type 2 diabetes

Publications

Featured Publications LegendFeatured Publications

Hyposialylated IgG activates endothelial IgG receptor Fc?RIIB to promote obesity-induced insulin resistance.
Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo C J. Clin. Invest. 2017 Nov
Toward optimization of in vivo super-resolution ultrasound imaging using size-selected microbubble contrast agents.
Ghosh D, Xiong F, Sirsi SR, Shaul PW, Mattrey RF, Hoyt K Med Phys 2017 Oct
27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy.
Oguro H, McDonald JG, Zhao Z, Umetani M, Shaul PW, Morrison SJ J. Clin. Invest. 2017 Sep 127 9 3392-3401
SIRT1 Protects Against Systemic Sclerosis-related Pulmonary Fibrosis by Decreasing Pro-inflammatory and Pro-fibrotic Processes.
Chu H, Jiang S, Liu Q, Ma Y, Zhu X, Liang M, Shi X, Ding W, Zhou X, Zou H, Qian F, Shaul PW, Jin L, Wang J Am. J. Respir. Cell Mol. Biol. 2017 Aug
17ß-estradiol dysregulates innate immune responses to Pseudomonas aeruginosa respiratory infection and is modulated by estrogen receptor antagonism.
Abid S, Xie S, Bose M, Shaul PW, Terada LS, Brody SL, Thomas PJ, Katzenellenbogen JA, Kim SH, Greenberg DE, Jain R Infect. Immun. 2017 Aug
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.
Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul PW, Heeren J Nat. Med. 2017 Jun
Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice.
Menazza S, Sun J, Appachi S, Chambliss KL, Kim SH, Aponte A, Khan S, Katzenellenbogen JA, Katzenellenbogen BS, Shaul PW, Murphy E J. Mol. Cell. Cardiol. 2017 Apr 107 41-51
New Insights in the Pathophysiology of Antiphospholipid Syndrome.
Sacharidou A, Shaul PW, Mineo C Semin. Thromb. Hemost. 2017 Jan
Non-Nuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.
Chambliss KL, Barrera J, Umetani M, Umetani J, Kim SH, Madak-Erdogan Z, Huang L, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW Endocrinology 2016 Aug en20151629
Endothelial Fc? Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice.
Tanigaki K, Chambliss KL, Yuhanna IS, Sacharidou A, Ahmed M, Atochin DN, Huang PL, Shaul PW, Mineo C Diabetes 2016 Apr

Books

Featured Books Legend Featured Books

Honors & Awards

  • Association of American Physicians
    (2013)
  • Associates First Capitol Corporation Distinguished Chair in Pediatrics
    (2011)
  • Hall of Honor, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
    (2010)
  • President, Society for Pediatric Research
    (2005-2006)
  • Codirector, Crystal Charity Ball Center for Research in Pediatric Critical Care
    (1997)
  • Lowe Foundation Professorship in Pediatric Critical Care Research
    (1997-2011)
  • Established Investigator Award, AHA
    (1993)

Professional Associations/Affiliations

  • Association of American Physicians (2013)
  • American Pediatric Society (2003)
  • American Society for Clinical Investigation (1999)
  • The American Physiological Society (1999)
  • Perinatal Research Society (1992-2013)
  • Society for Pediatric Research (1990)
  • American Academy of Pediatrics, Fellow (1987)
  • Dallas County Medical Society (1987)