Dr. Shaul received his B.A. from Dartmouth College and his M.D. from the University of Cincinnati. He received residency training in pediatrics at the Children's Medical Center of Cincinnati/University of Cincinnati followed by fellowship training in neonatal-perinatal medicine at Women and Infant's Hospital of Rhode Island/Brown University.
He joined the faculty of the University of Texas Southwestern Medical Center in 1986, and is the holder of the Associates First Capitol Corporation Distinguished Chair in Pediatrics at UT Southwestern. He is the Director of the Center for Pulmonary and Vascular Biology and Vice Chair for Research in the Department of Pediatrics, and a member of the Integrative Biology Graduate Program in the Division of Basic Science. Dr. Shaul was President of the Society for Pediatric Research in 2005-2006.
- Medical School
- University of Cincinnati College of Medicine (1981)
- Children's Hospital Medical Center -Cincinnati (1984), Pediatrics
- Brown University Medical School (1986), Neonatal-perinatal Medicine
- apolipoprotein E receptor 2 (LRP8)
- Caveolae, lipid rafts
- Fc receptors and cardiometabolic disorders
- Membrane-associated estrogen receptors
- Nitric oxide synthase
- Scavenger receptor class B, type I (HDL receptor)
- Vascular basis of type 2 diabetes
- C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice.
- Schwartz R, Osborne-Lawrence S, Hahner L, Gibson LL, Gormley AK, Vongpatanasin W, Zhu W, Word RA, Seetharam D, Black S, Samols D, Mineo C, Shaul PW Circ. Res. 2007 May 100 10 1452-9
- FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase.
- Mineo C, Gormley AK, Yuhanna IS, Osborne-Lawrence S, Gibson LL, Hahner L, Shohet RV, Black S, Salmon JE, Samols D, Karp DR, Thomas GD, Shaul PW Circ. Res. 2005 Nov 97 11 1124-31
- Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling.
- Assanasen C, Mineo C, Seetharam D, Yuhanna IS, Marcel YL, Connelly MA, Williams DL, de la Llera-Moya M, Shaul PW, Silver DL J. Clin. Invest. 2005 Apr 115 4 969-77
- High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase.
- Yuhanna IS, Zhu Y, Cox BE, Hahner LD, Osborne-Lawrence S, Lu P, Marcel YL, Anderson RG, Mendelsohn ME, Hobbs HH, Shaul PW Nat. Med. 2001 Jul 7 7 853-7
- Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen.
- Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, Shaul PW J. Clin. Invest. 1999 Feb 103 3 401-6
- Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae.
- Shaul PW, Smart EJ, Robinson LJ, German Z, Yuhanna IS, Ying Y, Anderson RG, Michel T J. Biol. Chem. 1996 Mar 271 11 6518-22
- Selective Non-nuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.
- Selvaraj UM, Zuurbier K, Whoolery C, Plautz EJ, Chambliss KL, Kong X, Zhang S, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW, Stowe AM Endocrinology 2018 Sep
- Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability.
- Peng J, Yu J, Xu H, Kang C, Shaul PW, Guan Y, Zhang X, Su W Cell. Physiol. Biochem. 2018 May 47 2 784-799
- Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.
- Sacharidou A, Chambliss KL, Ulrich V, Salmon JE, Shen YM, Herz J, Hui DY, Terada LS, Shaul PW, Mineo C Blood 2018 Mar
- Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells.
- Morel E, Ghezzal S, Lucchi G, Truntzer C, Pais de Barros JP, Simon-Plas F, Demignot S, Mineo C, Shaul PW, Leturque A, Rousset M, Carrière V Biochim. Biophys. Acta 2018 Feb 1863 2 199-211
Physiology of Nitric Oxide in the Developing Lung. In Polin RA, Fox WW, Abman SH, eds. Fetal and Neonatal Physiology. 4th ed.
Kinsella JP, Shaul PW. (2011). Philadelphia: Elsevier Saunders; 807-820.
Pulmonary Hypertension Syndromes. In Levin DL, Morriss FC, eds. Essentials of Pediatric Intensive Care. Vol 2.
Zellers TM, Shaul PW. (1997). Churchill Livingstone; 188-195.
Regulation of eNOS in Caveolae. In Jasmin J, Frank P, Lisanti MP, eds. Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms.
Mineo C, Shaul PW. (2012.). New York: Springer; 51-62.
Caveolae and Estrogen Receptor Signaling. In Lisanti ML, Frank PG, eds. Advances in Molecular and Cell Biology Series. Vol 36.
Shaul PW, Chambliss KL. (2005). Elsevier; 109-123.
Regulation of Endothelial NO Synthase Activity by Estrogen Receptors in a Steroid Receptor Fast-Action Complex (SRFC) In Caveolae. In Watson CS, ed. The Identities of Membrane Steroid Receptors.
Shaul PW, Chambliss KL, Mineo C. (2003). Norwell, MA: Kluwer Academic Publishers; 27-36.
Honors & Awards
- Association of American Physicians
- Associates First Capitol Corporation Distinguished Chair in Pediatrics
- Hall of Honor, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
- President, Society for Pediatric Research
- Codirector, Crystal Charity Ball Center for Research in Pediatric Critical Care
- Lowe Foundation Professorship in Pediatric Critical Care Research
- Established Investigator Award, AHA
- Association of American Physicians (2013)
- American Pediatric Society (2003)
- American Society for Clinical Investigation (1999)
- The American Physiological Society (1999)
- Perinatal Research Society (1992-2013)
- Society for Pediatric Research (1990)
- American Academy of Pediatrics, Fellow (1987)
- Dallas County Medical Society (1987)