Philip Shaul, M.D. Titles and Appointments Director, Center for Pulmonary and Vascular Biology Professor Endowed Title Associates First Capital Corporation Distinguished Chair in Pediatrics Schools Medical School | Graduate School Departments Pediatrics Graduate Programs Genetics, Development and Disease Biography Download Curriculum Vitae Dr. Shaul received his B.A. from Dartmouth College and his M.D. from the University of Cincinnati. He received residency training in pediatrics at the Children's Medical Center of Cincinnati/University of Cincinnati followed by fellowship training in neonatal-perinatal medicine at Women and Infant's Hospital of Rhode Island/Brown University. He joined the faculty of the University of Texas Southwestern Medical Center in 1986, and is the holder of the Associates First Capitol Corporation Distinguished Chair in Pediatrics at UT Southwestern. He is the Director of the Center for Pulmonary and Vascular Biology and Vice Chair for Research in the Department of Pediatrics, and a member of the Integrative Biology Graduate Program in the Division of Basic Science. Dr. Shaul was President of the Society for Pediatric Research in 2005-2006. Education Undergraduate Dartmouth College (1977) Medical School Central South Univ, Xiang-Ya S (1981) Medical School Unlisted - College or Universi (1981) Research Interest apolipoprotein E receptor 2 (LRP8) Caveolae, lipid rafts Fc receptors and cardiometabolic disorders Membrane-associated estrogen receptors Nitric oxide synthase Scavenger receptor class B, type I (HDL receptor) Vascular basis of type 2 diabetes Publications Role of the endothelial cell apolipoprotein E receptor 2 in modulating the effects of apoE3 and apoE4 on insulin blood-brain barrier transport Thomas P, Nguyen V, Weaver R, Hansen K, Sacharidou A, Banks WA, Mineo C, Shaul PW, Rhea EM PloS one 2026 Feb 21 Regulation of Insulin Transcytosis Across Endothelium in Metabolic Health and Disease Mineo C, Shaul PW Arteriosclerosis, Thrombosis, and Vascular Biology 2026 Feb 46 e321545 Apolipoprotein E receptor 2 in endothelium promote glucose tolerance by mediating insulin delivery to skeletal muscle Sacharidou A, Chambliss KL, Peng J, Tanigaki K, Islam MN, Sirsi S, Lemoff A, Hoyt K, Mineo C, Shaul PW Molecular Metabolism 2025 Nov 101 The ACTH test fails to diagnose adrenal insufficiency and augments cytokine production in sepsis Hao D, Wang Q, Ito M, Xue J, Guo L, Huang B, Mineo C, Shaul PW, Li XA JCI Insight 2025 Apr 10 27-hydroxycholesterol and endothelial cell immune memory link maternal hypercholesterolemia with atherosclerosis in the offspring: Atherogenesis Mineo C, Shaul PW Nature Cardiovascular Research 2025 Apr 4 350-352 Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue Hurkmans KM, Heine M, Rinninger F, Jaeckstein MY, Mineo C, Shaul PW, Heeren J Journal of lipid research 2025 66 Correction to: 27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer (Cancers, (2022), 14, 6, (1521), 10.3390/cancers14061521) Avena P, Casaburi I, Zavaglia L, Nocito MC, La Padula D, Rago V, Dong J, Thomas P, Mineo C, Sirianni R, Shaul PW Cancers 2024 Dec 16 Elevated free cholesterol levels due to impaired reverse cholesterol transport are a risk factor for polymicrobial sepsis in mice Wang Q, Guo L, Hao D, Ito M, Mineo C, Shaul PW, Li XA Journal of Biological Chemistry 2024 Dec 300 Alterations in plasma protein N-glycosylation after caloric restriction and bariatric surgery Štambuk T, Kifer D, Greto VL, Dempster NJ, Cvetko A, Gillies RS, Tomlinson JW, Sgromo B, Mineo C, Shaul PW, Lauc G, Lingvay I, Geremia A, Arancibia-Cárcamo CV Surgery for Obesity and Related Diseases 2024 Jun 20 587-596 Relative Adrenal Insufficiency Is a Risk Factor for Pediatric Sepsis: A Proof-of-Concept Study Hao D, Guo L, Wang Q, Ito M, Huang B, Mineo C, Shaul PW, Li XA Journal of Infectious Diseases 2024 Apr 229 1166-1177 Results 1-10 of 215 1 2 3 4 5 Next Last Books Featured Books Physiology of Nitric Oxide in the Developing Lung. In Polin RA, Fox WW, Abman SH, eds. Fetal and Neonatal Physiology. 4th ed. Kinsella JP, Shaul PW. (2011). Philadelphia: Elsevier Saunders; 807-820. Pulmonary Hypertension Syndromes. In Levin DL, Morriss FC, eds. Essentials of Pediatric Intensive Care. Vol 2. Zellers TM, Shaul PW. (1997). Churchill Livingstone; 188-195. Regulation of eNOS in Caveolae. In Jasmin J, Frank P, Lisanti MP, eds. Caveolins and Caveolae: Roles in Signaling and Disease Mechanisms. Mineo C, Shaul PW. (2012.). New York: Springer; 51-62. Caveolae and Estrogen Receptor Signaling. In Lisanti ML, Frank PG, eds. Advances in Molecular and Cell Biology Series. Vol 36. Shaul PW, Chambliss KL. (2005). Elsevier; 109-123. Regulation of Endothelial NO Synthase Activity by Estrogen Receptors in a Steroid Receptor Fast-Action Complex (SRFC) In Caveolae. In Watson CS, ed. The Identities of Membrane Steroid Receptors. Shaul PW, Chambliss KL, Mineo C. (2003). Norwell, MA: Kluwer Academic Publishers; 27-36. Honors & Awards Association of American Physicians (2013) Associates First Capitol Corporation Distinguished Chair in Pediatrics (2011) Hall of Honor, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine (2010) President, Society for Pediatric Research (2005-2006) Codirector, Crystal Charity Ball Center for Research in Pediatric Critical Care (1997) Lowe Foundation Professorship in Pediatric Critical Care Research (1997-2011) Established Investigator Award, AHA (1993) Professional Associations/Affiliations American Academy of Pediatrics, Fellow (1987) American Pediatric Society (2003) American Society for Clinical Investigation (1999) Association of American Physicians (2013) Dallas County Medical Society (1987) Perinatal Research Society (1992-2013) Society for Pediatric Research (1990) The American Physiological Society (1999)
