Biography

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Dr. Jacques Lux obtained his PhD in chemistry at the University of Strasbourg under the guidance of Nobel Prize laureate Jean-Pierre Sauvage. His Ph.D. projects aimed at designing and developing synthetic molecular machines reminiscent of biological systems. Following his Ph.D., Dr. Lux conducted postdoctoral research at the faculty of pharmacy in Strasbourg, where he developed activatable optical probes for the detection of viral RNA. He then came to the U.S. to train in supramolecular chemistry in Professor Julius Rebek Jr.’s laboratory at the Scripps Research Institute in La Jolla, CA. Dr. Lux received another postdoc opportunity at UCSD applying his skills in organic and coordination chemistry to the field of material science, and then became a Research Scientist to develop and translate theranostics for imaging and drug delivery.

While at UCSD, he designed and synthetized a novel MR contrast agent that incorporated gadolinium that was chelated and linked to hydrogel nanoparticles (nanogels). The advantage of this strategy is not only the development of high relaxivity T1 agents, but also minimizing demetallation. The versatility of this platform was demonstrated by incorporating 64Cu instead of gadolinium that allowed for in vivo PET/CT imaging of cancer. Dr. Lux also participated in the development of novel activatable optical nanoprobes for the detection of inflammation.

He recently joined the newly established Translational Research in Ultrasound Theranostics (TRUST) program at UT Southwestern in the Department of Radiology focusing on the development of targeted and activatable ultrasound (US) agents that not only aid in cancer detection, but also under US control, release drugs and/or destroy tumors with high intensity focused ultrasound.

Education

Undergraduate
University of Upper Alsace (2004), Chemistry
Graduate School
University of Upper Alsace (2006), Chemistry
Graduate School
University of Strasbourg (2009), Chemistry

Research Interest

  • Activatable ultrasound imaging contrast agents
  • Bioresponsive Theranostics
  • Drug Delivery
  • Nanomedicine
  • PET/MRI Nanoprobes
  • Ultrasound Theranostics

Publications

Featured Publications LegendFeatured Publications

Near-infrared-induced heating of confined water in polymeric particles for efficient payload release.
Viger ML, Sheng W, Doré K, Alhasan AH, Carling CJ, Lux J, de Gracia Lux C, Grossman M, Malinow R, Almutairi A ACS Nano 2014 May 8 5 4815-26
Synthesis and recognition studies with a ditopic, photoswitchable deep cavitand.
Busseron E, Lux J, Degardin M, Rebek J Chem. Commun. (Camb.) 2013 May 49 42 4842-4
Reversible switching between self-assembled homomeric and hybrid capsules.
Lux J, Rebek J Chem. Commun. (Camb.) 2013 Mar 49 21 2127-9
Malachite green derivatives for two-photon RNA detection.
Lux J, Peña EJ, Bolze F, Heinlein M, Nicoud JF Chembiochem 2012 May 13 8 1206-13
[2]Catenanes built around octahedral transition-metal complexes that contain two intertwined endocyclic but non-sterically hindering tridentate ligands.
Ayme JF, Lux J, Sauvage JP, Sour A Chemistry 2012 Apr 18 18 5565-73
Two-photon dyes and nucleic acid detection, Nonlinear Optics and Quantum Optics
Bolze F, Lux J, Peña E, Heinlein M, Wong MS, Nicoud JF 2012 45 29-39
Bigger, better, faster: molecular shuttles with sterically non-hindering biisoquinoline chelates
Durola F, Lux J, Sauvage JP, Wenger OS Supramolecular Chemistry 2011 23 42-52
A copper-based shuttling [2]rotaxane with two bidentate chelates in the axis: steric control of the motion
Collin JP, Durola F, Lux J, Sauvage JP New J Chem 2010 34 34-43
A rapidly shuttling copper-complexed [2]rotaxane with three different chelating groups in its axis.
Collin JP, Durola F, Lux J, Sauvage JP Angew. Chem. Int. Ed. Engl. 2009 48 45 8532-5
A fast-moving copper-based molecular shuttle: synthesis and dynamic properties.
Durola F, Lux J, Sauvage JP Chemistry 2009 15 16 4124-34

Honors & Awards

  • 2017 Docstars Award presented by the Cary Council
    In recognition and support of promising early-stage research (2017)