Dr. Jacques Lux obtained his PhD in chemistry at the University of Strasbourg under the guidance of Nobel Prize laureate Jean-Pierre Sauvage. His Ph.D. projects aimed at designing and developing synthetic molecular machines reminiscent of biological systems. Following his Ph.D., Dr. Lux conducted postdoctoral research at the faculty of pharmacy in Strasbourg, where he developed activatable optical probes for the detection of viral RNA. He then came to the U.S. to train in supramolecular chemistry in Professor Julius Rebek Jr.’s laboratory at the Scripps Research Institute in La Jolla, CA. Dr. Lux received another postdoc opportunity at UCSD applying his skills in organic and coordination chemistry to the field of material science, and then became a Research Scientist to develop and translate theranostics for imaging and drug delivery.
While at UCSD, he designed and synthetized a novel MR contrast agent that incorporated gadolinium that was chelated and linked to hydrogel nanoparticles (nanogels). The advantage of this strategy is not only the development of high relaxivity T1 agents, but also minimizing demetallation. The versatility of this platform was demonstrated by incorporating 64Cu instead of gadolinium that allowed for in vivo PET/CT imaging of cancer. Dr. Lux also participated in the development of novel activatable optical nanoprobes for the detection of inflammation.
He recently joined the newly established Translational Research in Ultrasound Theranostics (TRUST) program at UT Southwestern in the Department of Radiology focusing on the development of targeted and activatable ultrasound (US) agents that not only aid in cancer detection, but also under US control, release drugs and/or destroy tumors with high intensity focused ultrasound.
- University of Upper Alsace (2004), Chemistry
- Graduate School
- University of Upper Alsace (2006), Chemistry
- Graduate School
- University of Strasbourg (2009), Chemistry
- Activatable ultrasound imaging contrast agents
- Bioresponsive Theranostics
- Drug Delivery
- PET/MRI Nanoprobes
- Ultrasound Theranostics
- Thrombin-Activatable Microbubbles as Potential Ultrasound Contrast Agents for the Detection of Acute Thrombosis.
- Lux J, Vezeridis AM, Hoyt K, Adams SR, Armstrong AM, Sirsi SR, Mattrey RF ACS Appl Mater Interfaces 2017 Nov 9 43 37587-37596
- Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast.
- Viger ML, Collet G, Lux J, Nguyen Huu VA, Guma M, Foucault-Collet A, Olejniczak J, Joshi-Barr S, Firestein GS, Almutairi A Biomaterials 2017 Mar 133 119-131
- Long-Lasting and Efficient Tumor Imaging Using a High Relaxivity Polysaccharide Nanogel Magnetic Resonance Imaging Contrast Agent.
- Chan M, Lux J, Nishimura T, Akiyoshi K, Almutairi A Biomacromolecules 2015 Aug
- Nanogels from metal-chelating crosslinkers as versatile platforms applied to copper-64 PET imaging of tumors and metastases.
- Lux J, White AG, Chan M, Anderson CJ, Almutairi A Theranostics 2015 5 3 277-88
- Metal Chelating Crosslinkers Form Nanogels with High Chelation Stability.
- Lux J, Chan M, Elst LV, Schopf E, Mahmoud E, Laurent S, Almutairi A J Mater Chem B Mater Biol Med 2013 Dec 1 46 6359-6364
- Advances in gadolinium-based MRI contrast agent designs for monitoring biological processes in vivo.
- Lux J, Sherry AD Curr Opin Chem Biol 2018 May 45 121-130
- Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction.
- Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A Proc. Natl. Acad. Sci. U.S.A. 2016 Mar
- Light-triggered chemical amplification to accelerate degradation and release from polymeric particles.
- Olejniczak J, Nguyen Huu VA, Lux J, Grossman M, He S, Almutairi A Chem. Commun. (Camb.) 2015 Oct
- Short Soluble Coumarin Crosslinkers for Light Controlled Release of Cells and Proteins from Hydrogels.
- de Gracia Lux C, Lux J, Collet G, He S, Chan M, Olejniczak J, Foucault-Collet A, Almutairi A Biomacromolecules 2015 Sep
- Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye.
- Huu VA, Luo J, Zhu J, Zhu J, Patel S, Boone A, Mahmoud E, McFearin C, Olejniczak J, de Gracia Lux C, Lux J, Fomina N, Huynh M, Zhang K, Almutairi A J Control Release 2015 Feb 200 71-7
Honors & Awards
- 2017 Docstars Award presented by the Cary Council
In recognition and support of promising early-stage research (2017)