Biography

Dr. Park received both his undergraduate and graduate degrees in Electrical Engineering. His doctoral work at Stanford University was focused on technical developments of magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) with application to preclinical glioma brain tumor metabolism. Following completion of his Ph.D. in 2012, he broadened his research into advanced biomedical imaging as a postdoctoral research fellow and a research associate in the Department of Radiology at Stanford School of Medicine. He joined the UT Southwestern as an Assistant Professor in 2016 and became an Associate Professor (with tenure) in 2022.

Dr. Park's lab has been focused on methodological developments and clinical translation of metabolic imaging, particularly of mitochondria, enabling in vivo assessment of metabolic fluxes in individual enzyme-catalyzed reactions. As metabolic processes and their regulation are complex, numerous transient physiological conditions, including nutritional states and exercise, impact metabolism. Chronic diseases such as cancer and type 2 diabetes may also have profound effects. For accurate and selective imaging of metabolism and function of interests, his lab develops imaging concepts and schemes by developing a network of ideas in MR pulse sequence, physiology, chemistry, and clinical translation.

Education

Graduate School
Stanford University (2009), Electrical Engineering
Graduate School
Stanford University (2012), Electrical Engineering

Research Interest

  • Cancer metabolism
  • Development of hyperpolarized MR spectroscopic imaging methods
  • Metabolic imaging agents
  • Metabolic imaging of cardiomyopathy
  • Neurological disorders and neuroinflammation
  • Quantitative neuroimaging techniques

Publications

Featured Publications LegendFeatured Publications

Functional activation of pyruvate dehydrogenase in human brain using hyperpolarized [1-13C]pyruvate
Zaidi M, Ma J, Thomas BP, Pena S, Harrison CE, Chen J, Lin SH, Derner K, Baxter JD, Liticker J, Malloy CR, Bartnik-Olson B, Park JM Magn Reson Med 2024 5 91 1822-1833
Hyperpolarized [2-13C, 3-2H3]pyruvate detects hepatic gluconeogenesis in vivo
Huynh MT, Erfani Z, Kovacs Z, Park JM ACS Sens 2024 In press
Investigating the origin of the 13 C lactate signal in the anesthetized healthy rat brain in vivo after hyperpolarized [1-13 C]pyruvate injection.
Zhu M, Jhajharia A, Josan S, Park JM, Yen YF, Pfefferbaum A, Hurd RE, Spielman DM, Mayer D, NMR Biomed 2023 Nov e5073
Longitudinal assessment of mitochondrial dysfunction in acute traumatic brain injury using hyperpolarized [1-13C]pyruvate
Hackett EP, Chen J, Ingle L, Al Nemri S, Barshikar S, Pinho MC, Plautz EJ, Bartnik-Olson BL, Park JM Magn Reson Med 2023 6 90 2432-2442
Hyperpolarized [1-13C]acetyl-L-carnitine probes TCA cycle activity in vivo
Chen J, Singh TK, Al Nemri S, Zaidi M, Billingsley KL, Park JM ACS Sens 2023 8 8 2927-2932
Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe.
Park H, Chen J, Dimitrov IE, Park JM, Wang Q, ACS Sens 2022 Oct
Profiling carbohydrate metabolism in liver and hepatocellular carcinoma with 13C-glycerate probes.
Chen J, LaGue E, Li J, Yang C, Hackett EP, Mendoza M, Alger JR, DeBerardinis RJ, Corbin IR, Billingsley KL, Park JM, Analysis & Sensing 2021 Nov 4 1 196-202
13C-labeled diethyl ketoglutarate derivatives as hyperpolarized probes of 2-ketoglutarate dehydrogenase activity.
Singh J, Suh EH, Sharma G, Chen J, Hackett EP, Wen X, Sherry AD, Khemtong C, Malloy CR, Park JM, Kovács Z, Analysis & Sensing 2021 Nov 4 1 156-160
Dynamic 13 C MR spectroscopy as an alternative to imaging for assessing cerebral metabolism using hyperpolarized pyruvate in humans.
Ma J, Pinho MC, Harrison CE, Chen J, Sun C, Hackett EP, Liticker J, Ratnakar J, Reed GD, Chen AP, Sherry AD, Malloy CR, Wright SM, Madden CJ, Park JM, Magn Reson Med 2021 Oct
Dual-phase imaging of cardiac metabolism using hyperpolarized pyruvate.
Ma J, Malloy CR, Pena S, Harrison CE, Ratnakar J, Zaha VG, Park JM, Magn Reson Med 2021 Oct

Books

Featured Books Legend Featured Books

Insights on lactate metabolism in skeletal muscle based on 13C dynamic nuclear polarization studies. In Dynamic Hyperpolarized Nuclear Magnetic Resonance. Handbook of Modern Biophysics

Park JM, Jue T (2021). Springer, Cham

Kinetic modeling of enzymatic reactions in analyzing hyperpolarized NMR data. In Dynamic Hyperpolarized Nuclear Magnetic Resonance. Handbook of Modern Biophysics

Spielman DM, Park JM (2021). Springer, Cham

Assessing pyruvate carboxylase flux as a mechanistic biological marker in fasting. In Biomarkers in Nutrition

Chen J, Park JM (2022). Springer Nature

Technical considerations of MRI methods for validating DNP probes in small animals. In The Chemistry of Hyperpolarized Magnetic Resonance Probes

Harrison CE, Chen J, Lin SH, Park JM (2024). Elsevier

Honors & Awards

  • Gambhir-RSL Grant
    Stanford University (2015-2016)
  • Junior Fellow
    International Society of Magnetic Resonance in Medicine (2014-2014)
  • Radiology Department Research Funding Award
    Stanford University (2013-2014)
  • Cambridge Foundation Fellowship
    Graduate Scholarship (2007-2009)

Professional Associations/Affiliations

  • American Heart Association (2023)
  • International Society of Magnetic Resonance in Medicine (2009)
  • National Neurotrauma Society (2023)