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Jae Mo Park, Ph.D.

Jae Mo Park, Ph.D.

Associate Professor

School
Medical School
Department
Advanced Imaging Research Center | Biomedical Engineering | Radiology
Graduate Programs
Biomedical Engineering
  • Biography

    Dr. Park received both his undergraduate and graduate degrees in Electrical Engineering. His doctoral work at Stanford University was focused on technical developments of magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) with application to preclinical glioma brain tumor metabolism. Following completion of his Ph.D. in 2012, he broadened his research into advanced biomedical imaging as a postdoctoral research fellow and a research associate in the Department of Radiology at Stanford School of Medicine. He joined the UT Southwestern as an Assistant Professor in 2016 and became an Associate Professor (with tenure) in 2022.

    Dr. Park's lab has been focused on methodological developments and clinical translation of metabolic imaging, particularly of mitochondria, enabling in vivo assessment of metabolic fluxes in individual enzyme-catalyzed reactions. As metabolic processes and their regulation are complex, numerous transient physiological conditions, including nutritional states and exercise, impact metabolism. Chronic diseases such as cancer and type 2 diabetes may also have profound effects. For accurate and selective imaging of metabolism and function of interests, his lab develops imaging concepts and schemes by developing a network of ideas in MR pulse sequence, physiology, chemistry, and clinical translation.

  • Education
    Graduate School
    Stanford University (2009), Electrical Engineering
    Graduate School
    Stanford University (2012), Electrical Engineering
  • Research Interest
    • Cancer metabolism
    • Development of hyperpolarized MR spectroscopic imaging methods
    • Metabolic imaging agents
    • Metabolic imaging of cardiomyopathy
    • Neurological disorders and neuroinflammation
    • Quantitative neuroimaging techniques
  • Publications

    Star Featured Publications

    Functional activation of pyruvate dehydrogenase in human brain using hyperpolarized [1-13C]pyruvate
    Zaidi M, Ma J, Thomas BP, Pena S, Harrison CE, Chen J, Lin SH, Derner K, Baxter JD, Liticker J, Malloy CR, Bartnik-Olson B, Park JM Magn Reson Med 2024 May 91 5 1822-1833
    Hyperpolarized [2-13C, 3-2H3]pyruvate detects hepatic gluconeogenesis in vivo
    Huynh MT, Erfani Z, Kovacs Z, Park JM ACS Sens 2024 Jun 9 6 2801-2805
    Enhanced solubility and polarization of 13C-fumarate with meglumine allows for in vivo detection of gluconeogenic metabolism in kidneys
    Huynh MT, Erfani Z, Al Nemri S, Chirayil S, Kovacs Z, Park JM ACS Appl Mater Interfaces 2024 July In press
    Investigating the origin of the 13 C lactate signal in the anesthetized healthy rat brain in vivo after hyperpolarized [1-13 C]pyruvate injection.
    Zhu M, Jhajharia A, Josan S, Park JM, Yen YF, Pfefferbaum A, Hurd RE, Spielman DM, Mayer D, NMR Biomed 2023 Nov e5073
    Longitudinal assessment of mitochondrial dysfunction in acute traumatic brain injury using hyperpolarized [1-13C]pyruvate
    Hackett EP, Chen J, Ingle L, Al Nemri S, Barshikar S, Pinho MC, Plautz EJ, Bartnik-Olson BL, Park JM Magn Reson Med 2023 Dec 90 6 2432-2442
    Hyperpolarized [1-13C]acetyl-L-carnitine probes TCA cycle activity in vivo
    Chen J, Singh TK, Al Nemri S, Zaidi M, Billingsley KL, Park JM ACS Sens 2023 8 8 2927-2932
    Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe.
    Park H, Chen J, Dimitrov IE, Park JM, Wang Q, ACS Sens 2022 Oct
    Profiling carbohydrate metabolism in liver and hepatocellular carcinoma with 13C-glycerate probes.
    Chen J, LaGue E, Li J, Yang C, Hackett EP, Mendoza M, Alger JR, DeBerardinis RJ, Corbin IR, Billingsley KL, Park JM, Analysis & Sensing 2021 Nov 4 1 196-202
    13C-labeled diethyl ketoglutarate derivatives as hyperpolarized probes of 2-ketoglutarate dehydrogenase activity.
    Singh J, Suh EH, Sharma G, Chen J, Hackett EP, Wen X, Sherry AD, Khemtong C, Malloy CR, Park JM, Kovács Z, Analysis & Sensing 2021 Nov 4 1 156-160
    Dynamic 13 C MR spectroscopy as an alternative to imaging for assessing cerebral metabolism using hyperpolarized pyruvate in humans.
    Ma J, Pinho MC, Harrison CE, Chen J, Sun C, Hackett EP, Liticker J, Ratnakar J, Reed GD, Chen AP, Sherry AD, Malloy CR, Wright SM, Madden CJ, Park JM, Magn Reson Med 2021 Oct
  • Books

    Featured 

    Insights on lactate metabolism in skeletal muscle based on 13C dynamic nuclear polarization studies. In Dynamic Hyperpolarized Nuclear Magnetic Resonance. Handbook of Modern Biophysics

    Park JM, Jue T (2021). Springer, Cham

    Kinetic modeling of enzymatic reactions in analyzing hyperpolarized NMR data. In Dynamic Hyperpolarized Nuclear Magnetic Resonance. Handbook of Modern Biophysics

    Spielman DM, Park JM (2021). Springer, Cham

    Assessing pyruvate carboxylase flux as a mechanistic biological marker in fasting. In Biomarkers in Nutrition

    Chen J, Park JM (2022). Springer Nature

    Technical considerations of MRI methods for validating DNP probes in small animals. In The Chemistry of Hyperpolarized Magnetic Resonance Probes

    Harrison CE, Chen J, Lin SH, Park JM (2024). Elsevier

  • Honors & Awards
    • Gambhir-RSL Grant
      Stanford University (2015-2016)
    • Junior Fellow
      International Society of Magnetic Resonance in Medicine (2014-2014)
    • Radiology Department Research Funding Award
      Stanford University (2013-2014)
    • Cambridge Foundation Fellowship
      Graduate Scholarship (2007-2009)
  • Professional Associations/Affiliations
    • American Heart Association
    • IEEE
    • International Society of Magnetic Resonance in Medicine
    • National Neurotrauma Society