Jae Mo Park, Ph.D. Associate Professor School Medical School Department Advanced Imaging Research Center | Biomedical Engineering | Radiology Graduate Programs Biomedical Engineering Biography Dr. Park received both his undergraduate and graduate degrees in Electrical Engineering. His doctoral work at Stanford University was focused on technical developments of magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) with application to preclinical glioma brain tumor metabolism. Following completion of his Ph.D. in 2012, he broadened his research into advanced biomedical imaging as a postdoctoral research fellow and a research associate in the Department of Radiology at Stanford School of Medicine. He joined the UT Southwestern as an Assistant Professor in 2016 and became an Associate Professor (with tenure) in 2022. Dr. Park's lab has been focused on methodological developments and clinical translation of metabolic imaging, particularly of mitochondria, enabling in vivo assessment of metabolic fluxes in individual enzyme-catalyzed reactions. As metabolic processes and their regulation are complex, numerous transient physiological conditions, including nutritional states and exercise, impact metabolism. Chronic diseases such as cancer and type 2 diabetes may also have profound effects. For accurate and selective imaging of metabolism and function of interests, his lab develops imaging concepts and schemes by developing a network of ideas in MR pulse sequence, physiology, chemistry, and clinical translation. Education Graduate School Stanford University (2009), Electrical Engineering Graduate School Stanford University (2012), Electrical Engineering Research Interest Cancer metabolism Development of hyperpolarized MR spectroscopic imaging methods Metabolic imaging agents Metabolic imaging of cardiomyopathy Neurological disorders and neuroinflammation Quantitative neuroimaging techniques Publications Featured Publications Functional activation of pyruvate dehydrogenase in human brain using hyperpolarized [1-13C]pyruvate Zaidi M, Ma J, Thomas BP, Pena S, Harrison CE, Chen J, Lin SH, Derner K, Baxter JD, Liticker J, Malloy CR, Bartnik-Olson B, Park JM Magn Reson Med 2024 May 91 5 1822-1833 Hyperpolarized [2-13C, 3-2H3]pyruvate detects hepatic gluconeogenesis in vivo Huynh MT, Erfani Z, Kovacs Z, Park JM ACS Sens 2024 Jun 9 6 2801-2805 Enhanced solubility and polarization of 13C-fumarate with meglumine allows for in vivo detection of gluconeogenic metabolism in kidneys Huynh MT, Erfani Z, Al Nemri S, Chirayil S, Kovacs Z, Park JM ACS Appl Mater Interfaces 2024 July In press Investigating the origin of the 13 C lactate signal in the anesthetized healthy rat brain in vivo after hyperpolarized [1-13 C]pyruvate injection. Zhu M, Jhajharia A, Josan S, Park JM, Yen YF, Pfefferbaum A, Hurd RE, Spielman DM, Mayer D, NMR Biomed 2023 Nov e5073 Longitudinal assessment of mitochondrial dysfunction in acute traumatic brain injury using hyperpolarized [1-13C]pyruvate Hackett EP, Chen J, Ingle L, Al Nemri S, Barshikar S, Pinho MC, Plautz EJ, Bartnik-Olson BL, Park JM Magn Reson Med 2023 Dec 90 6 2432-2442 Hyperpolarized [1-13C]acetyl-L-carnitine probes TCA cycle activity in vivo Chen J, Singh TK, Al Nemri S, Zaidi M, Billingsley KL, Park JM ACS Sens 2023 8 8 2927-2932 Design and Characterization of Hyperpolarized 15N-BBCP as a H2O2-Sensing Probe. Park H, Chen J, Dimitrov IE, Park JM, Wang Q, ACS Sens 2022 Oct Profiling carbohydrate metabolism in liver and hepatocellular carcinoma with 13C-glycerate probes. Chen J, LaGue E, Li J, Yang C, Hackett EP, Mendoza M, Alger JR, DeBerardinis RJ, Corbin IR, Billingsley KL, Park JM, Analysis & Sensing 2021 Nov 4 1 196-202 13C-labeled diethyl ketoglutarate derivatives as hyperpolarized probes of 2-ketoglutarate dehydrogenase activity. Singh J, Suh EH, Sharma G, Chen J, Hackett EP, Wen X, Sherry AD, Khemtong C, Malloy CR, Park JM, Kovács Z, Analysis & Sensing 2021 Nov 4 1 156-160 Dynamic 13 C MR spectroscopy as an alternative to imaging for assessing cerebral metabolism using hyperpolarized pyruvate in humans. Ma J, Pinho MC, Harrison CE, Chen J, Sun C, Hackett EP, Liticker J, Ratnakar J, Reed GD, Chen AP, Sherry AD, Malloy CR, Wright SM, Madden CJ, Park JM, Magn Reson Med 2021 Oct Results 1-10 of 45 1 2 3 4 5 Next Last Books Featured Books Insights on lactate metabolism in skeletal muscle based on 13C dynamic nuclear polarization studies. In Dynamic Hyperpolarized Nuclear Magnetic Resonance. Handbook of Modern Biophysics Park JM, Jue T (2021). Springer, Cham Kinetic modeling of enzymatic reactions in analyzing hyperpolarized NMR data. In Dynamic Hyperpolarized Nuclear Magnetic Resonance. Handbook of Modern Biophysics Spielman DM, Park JM (2021). Springer, Cham Assessing pyruvate carboxylase flux as a mechanistic biological marker in fasting. In Biomarkers in Nutrition Chen J, Park JM (2022). Springer Nature Technical considerations of MRI methods for validating DNP probes in small animals. In The Chemistry of Hyperpolarized Magnetic Resonance Probes Harrison CE, Chen J, Lin SH, Park JM (2024). Elsevier Honors & Awards Gambhir-RSL GrantStanford University (2015-2016) Junior FellowInternational Society of Magnetic Resonance in Medicine (2014-2014) Radiology Department Research Funding AwardStanford University (2013-2014) Cambridge Foundation FellowshipGraduate Scholarship (2007-2009) Professional Associations/Affiliations American Heart Association IEEE International Society of Magnetic Resonance in Medicine National Neurotrauma Society
