Dr. Cai is a practicing neuropathologist and assistant professor in the Pathology Department at UT Southwestern Medical Center, Dallas, TX. He received his medical degree from Peking University Health Science Center, Beijing, China, PhD degree from Wesleyan University, Middletown, CT, and pathology residency and fellowship training at Washington University School of Medicine, St Louis, MO.
UTSW Medical Center is the largest referring center for muscle and nerve biopsies in Texas and receives biopsies specimens from over 100 institutions over a 6-state area. Dr. Cai's main clinical and research interests focus on the diagnosis of peripheral muscle and nerve diseases. We are the first and only clinical laboratory in the United States that has validated Morin stain for the diagnosis of macrophagic myofasciitis, a treatable, vaccine related inflammatory condition. Dr. Cai also published multiple articles on the diagnosis of diabetic neuropathy, inflammatory myopathies, congenital myopathy, and muscular dystrophies.
- Medical School
- Beijing Medical University, China (2001)
- Other Post Graduate Training
- Wesleyan University (2008)
- Graduate School
- Wesleyan University (2008), Biology
- Postdoctoral Fellowship
- University of Connecticut Health Center (2010), Neuroscience
- Washington University in St. Louis School of Medicine (2014), Anatomic/neuropathology
- Washington University in St. Louis School of Medicine (2015), Surgical Pathology
- Neuromuscular diseases
- Tumor ischemia and radio-resistance
- SWI/SNF deficient central nervous system neoplasms.
- Cai C, Semin Diagn Pathol 2021 May 38 3 167-174
- Distinct tissue injury patterns in juvenile dermatomyositis auto-antibody subgroups.
- Nguyen M, Do V, Yell PC, Jo C, Liu J, Burns DK, Wright T, Cai C, Acta Neuropathol Commun 2020 Aug 8 1 125
- A pattern-based approach to the interpretation of skeletal muscle biopsies.
- Cai C, Anthony DC, Pytel P Mod. Pathol. 2018 Nov
- Diffuse microvascular C5b-9 deposition is a common feature in muscle and nerve biopsies from diabetic patients.
- Yell PC, Burns DK, Dittmar EG, White CL, Cai C Acta Neuropathol Commun 2018 Feb 6 1 11
- Morin Stain Detects Aluminum-Containing Macrophages in Macrophagic Myofasciitis and Vaccination Granuloma With High Sensitivity and Specificity.
- Chkheidze R, Burns DK, White CL, Castro D, Fuller J, Cai C J. Neuropathol. Exp. Neurol. 2017 Mar
- The efficacy of immunohistochemistry in the diagnosis of molecular genetic alterations in central nervous system gliomas: Next-generation sequencing of 212 mutations in 112 patients.
- Daoud EV, Chkheidze R, Yell PC, Hatanpaa KJ, Raisanen JM, Cai C, Clin Neuropathol 2021 Oct
- Preoperative imaging of glioblastoma patients using hyperpolarized 13C pyruvate: Potential role in clinical decision making.
- Chen J, Patel TR, Pinho MC, Choi C, Harrison CE, Baxter JD, Derner K, Pena S, Liticker J, Raza J, Hall RG, Reed GD, Cai C, Hatanpaa KJ, Bankson JA, Bachoo RM, Malloy CR, Mickey BE, Park JM, Neurooncol Adv 2021 Jan-Dec 3 1 vdab092
- The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization.
- Ramirez-Martinez A, Zhang Y, Chen K, Kim J, Cenik BK, McAnally JR, Cai C, Shelton JM, Huang J, Brennan A, Evers BM, Mammen PPA, Xu L, Bassel-Duby R, Liu N, Olson EN, Nat Commun 2021 01 12 1 690
- Biallelic loss of function variants in SYT2 cause a treatable congenital onset presynaptic myasthenic syndrome.
- Donkervoort S, Mohassel P, Laugwitz L, Zaki MS, Kamsteeg EJ, Maroofian R, Chao KR, Verschuuren-Bemelmans CC, Horber V, Fock AJM, McCarty RM, Jain MS, Biancavilla V, McMacken G, Nalls M, Voermans NC, Elbendary HM, Snyder M, Cai C, Lehky TJ, Stanley V, Iannaccone ST, Foley AR, Lochmüller H, Gleeson J, Houlden H, Haack TB, Horvath R, Bönnemann CG, Am. J. Med. Genet. A 2020 Aug
- Multi-Site Optical Monitoring of Spinal Cord Ischemia During Spine Distraction.
- Busch D, Lin W, Cai C, Cutrone AM, Tatka J, Kovarovic BJ, Yodh AG, Floyd TF, Barsi J, J. Neurotrauma 2020 May
A case-based guide to neuromuscular pathology
Lan Zhou, Dennis K. Burns, Chunyu Cai (Ed.) (2019). Switzerland, Springer
Honors & Awards
- Keifer Graduate Research Award, Wesleyan University
- Leadership Emerging in Academic Department (LEAD)
Junior Faculty LEAD Program for Physician &Scientists
- Outstanding Student Award, Beijing Medical University
- Pathologyoutlines (2020)
- Chinese American Pathologists Association (CAPA) (2018)
- Journal of Neuropathology and Experimental Neurology (JNEN) (2018)
- Texas Medical Association (2017)
- College of American Pathologists (CAP) (2015)
- American Association of Neuropathologists (AANP) (2014)
- American Board of Pathology (ABP) (2014)
- United States and Canadian Academy of Pathology (USCAP) (2014)