Download Curriculum Vitae

Lukasz Joachimiak received his B.S. in Biochemistry from the University of Wisconsin-Madison in 2000.  He received his Ph.D. in 2007 working in the lab of David Baker at University of Washington where he established computational tools to define the energetic and structural principles that underlie protein-protein interactions.  He completed his postdoctoral work with Judith Frydman at Stanford University where he developed innovative approaches to understand the structure and mechanics of substrate interaction by the eukaryotic chaperonin TRiC/CCT.

At UT Southwestern Medical Center, Dr. Joachimiak's laboratory will utilize structural and biochemical approaches to dissect the role of chaperones and protein misfolding in neurodegenerative diseases.  His group is also interested in integrating experimental and computational methods to predict the structures of protein complexes not tractable by classical structural biology techniques.





Uni of Wisconsin-Madison (2001), Biochemistry
Graduate School
University of Washington (2007), Biochemistry

Research Interest

  • Chaperone structual biology
  • Molecular recognition and specificity
  • Neurodegeneration


Featured Publications LegendFeatured Publications

The interactions that shape amyloid fibrils in disease.
Joachimiak LA, Structure 2022 Aug 30 8 1045-1047
Seed-competent tau monomer initiates pathology in a tauopathy mouse model.
Mirbaha H, Chen D, Mullapudi V, Terpack SJ, White CL, Joachimiak LA, Diamond MI, J Biol Chem 2022 Jun 102163
The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics.
Wickramaratne AC, Li L, Hopkins JB, Joachimiak LA, Green CB, Biochemistry 2022 May
Chaperoning shape-shifting tau in disease.
Ryder BD, Wydorski PM, Hou Z, Joachimiak LA, Trends Biochem Sci 2022 Jan

Honors & Awards

  • Endowed Scholar Award