Biography

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Lukasz Joachimiak received his B.S. in Biochemistry from the University of Wisconsin-Madison in 2000.  He received his Ph.D. in 2007 working in the lab of David Baker at University of Washington where he established computational tools to define the energetic and structural principles that underlie protein-protein interactions.  He completed his postdoctoral work with Judith Frydman at Stanford University where he developed innovative approaches to understand the structure and mechanics of substrate interaction by the eukaryotic chaperonin TRiC/CCT.

At UT Southwestern Medical Center, Dr. Joachimiak's laboratory will utilize structural and biochemical approaches to dissect the role of chaperones and protein misfolding in neurodegenerative diseases.  His group is also interested in integrating experimental and computational methods to predict the structures of protein complexes not tractable by classical structural biology techniques.

 

 

 

Education

Undergraduate
Uni of Wisconsin-Madison (2001), Biochemistry
Graduate School
University of Washington (2007), Biochemistry

Research Interest

  • Chaperone structual biology
  • Molecular recognition and specificity
  • Neurodegeneration

Publications

Featured Publications LegendFeatured Publications

Chaperoning shape-shifting tau in disease.
Ryder BD, Wydorski PM, Hou Z, Joachimiak LA, Trends Biochem Sci 2022 Jan
Modifying Amyloid Motif Aggregation Through Local Structure.
Bali S, Joachimiak LA, Methods Mol Biol 2022 2340 343-356
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J, Cell 2019 Apr 177 3 751-765.e15
The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story.
Gestaut D, Limatola A, Joachimiak L, Frydman J, Curr. Opin. Struct. Biol. 2019 Apr 55 50-58

Honors & Awards

  • Endowed Scholar Award
    (2016-2020)