Download Curriculum Vitae

Lukasz Joachimiak received his B.S. in Biochemistry from the University of Wisconsin-Madison in 2000.  He received his Ph.D. in 2007 working in the lab of David Baker at University of Washington where he established computational tools to define the energetic and structural principles that underlie protein-protein interactions.  He completed his postdoctoral work with Judith Frydman at Stanford University where he developed innovative approaches to understand the structure and mechanics of substrate interaction by the eukaryotic chaperonin TRiC/CCT.

At UT Southwestern Medical Center, Dr. Joachimiak's laboratory utilizes structural and biochemical approaches to dissect the role of chaperones and protein misfolding in neurodegenerative diseases.  His group is also interested in integrating experimental and computational methods to predict the structures of protein complexes not tractable by classical structural biology techniques.





Uni of Wisconsin-Madison (2001), Biochemistry
Graduate School
University of Washington (2007), Biochemistry

Research Interest

  • Chaperone structual biology
  • Molecular recognition and specificity
  • Protein (mis)folding in neurodegenerative diseases


Featured Publications LegendFeatured Publications

Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength.
Rios MU, Bagnucka MA, Ryder BD, Ferreira Gomes B, Familiari NE, Yaguchi K, Amato M, Stachera WE, Joachimiak LA, Woodruff JB, J Cell Biol 2024 Apr 223 4
Hairpin trimer transition state of amyloid fibril.
Sari L, Bali S, Joachimiak LA, Lin MM, Nat Commun 2024 Mar 15 1 2756
J-domain proteins: From molecular mechanisms to diseases.
Marszalek J, De Los Rios P, Cyr D, Mayer MP, Adupa V, Andréasson C, Blatch GL, Braun JEA, Brodsky JL, Bukau B, Chapple JP, Conz C, Dementin S, Genevaux P, Genest O, Goloubinoff P, Gestwicki J, Hammond CM, Hines JK, Ishikawa K, Joachimiak LA, Kirstein J, Liberek K, Mokranjac D, Nillegoda N, Ramos CHI, Rebeaud M, Ron D, Rospert S, Sahi C, Shalgi R, Tomiczek B, Ushioda R, Ustyantseva E, Ye Y, Zylicz M, Kampinga HH, Cell Stress Chaperones 2023 Dec 29 1 21-33
Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation.
Chlebowicz J, Russ W, Chen D, Vega A, Vernino S, White CL, Rizo J, Joachimiak LA, Diamond MI, Sci Adv 2023 Oct 9 43 eadh3457
Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds.
Hitt BD, Gupta A, Singh R, Yang T, Beaver JD, Shang P, White CL, Joachimiak LA, Diamond MI, J Biol Chem 2023 Sep 105252

Honors & Awards

  • Endowed Scholar Award