Vlad Gabriel Zaha, M.D., Ph.D., is an Associate Professor of Internal Medicine at UT Southwestern Medical Center, and a member of its Cardiology Divsion. He specializes in cardio-oncology and advanced cardiovascular imaging diagnostic modalities.
Dr. Zaha earned his medical degree at Carol Davila University of Medicine & Pharmacy in Bucharest. He went on to conduct research studies of myocardial cell biology, investigating insulin signaling and glucose-transport mechanisms in the heart.
He earned his doctoral degree summa cum laude at the University of Freiburg in Germany and completed a postdoctoral fellowship in molecular biology and genetics at the University of Utah, where he conducted studies to elucidate molecular and genetic connections that underlie the energetic metabolism in the heart, funded by a fellowship award from the American Heart Association. Dr. Zaha also conducted studies of molecular mechanisms for protection of myocardial mitochondria and was recognized as a finalist at the 2014 Northwestern Young Investigator Forum.
Dr. Zaha completed a residency in internal medicine at Indiana University and a fellowship in cardiology at Yale University and University College London, specializing in cardio-oncology and advanced cardiovascular imaging.
He joined the UT Southwestern faculty in 2016.
Since March 2018, Dr. Zaha has served in the leadership council of the Cardio-Oncology Section of the American College of Cardiology. Other professional organizations in which he is active include the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the Society for Cardiovascular Magnetic Resonance, and the International Society for Magnetic Resonance in Medicine.
- Medical School
- Carol Davila University of Medicine & Pharmacy (1999)
- Other Post Graduate Training
- University of Freiburg, Germany (2003)
- Research Fellowship
- University of UTAH (2006), Molecular Genetics
- Indiana University School of Medicine (2007), Internal Medicine
- Indiana University School of Medicine (2009), Internal Medicine
- Yale New Haven Medical Center (2015), Cardiovascular Medicine
- Mitochondrial Biology
- Molecular Imaging
- Myocardial Protection
- AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia.
- Zaha VG, Qi D, Su KN, Palmeri M, Lee HY, Hu X, Wu X, Shulman GI, Rabinovitch PS, Russell RR, Young LH J. Mol. Cell. Cardiol. 2015 Dec 91 104-113
- AMP-activated protein kinase regulation and biological actions in the heart.
- Zaha VG, Young LH Circ. Res. 2012 Aug 111 6 800-14
- PGC-1? deficiency accelerates the transition to heart failure in pressure overload hypertrophy.
- Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED Circ. Res. 2011 Sep 109 7 783-93
- A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
- Kim AS, Miller EJ, Wright TM, Li J, Qi D, Atsina K, Zaha V, Sakamoto K, Young LH J. Mol. Cell. Cardiol. 2011 Jul 51 1 24-32
- Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.
- Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED Circulation 2009 Mar 119 9 1272-83
- Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.
- Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED Diabetes 2008 Nov 57 11 2924-32
- A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.
- O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED Cell Metab. 2007 Oct 6 4 294-306
- Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.
- Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED Diabetes 2007 Oct 56 10 2457-66
- Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.
- Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A PLoS Biol. 2006 Nov 4 11 e369
- Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action.
- Graveleau C, Zaha VG, Mohajer A, Banerjee RR, Dudley-Rucker N, Steppan CM, Rajala MW, Scherer PE, Ahima RS, Lazar MA, Abel ED J. Biol. Chem. 2005 Sep 280 36 31679-85
Honors & Awards
Northwestern University Young Investigator Forum (2014)
- High Score Abstract
Euro-Imaging, Vienna, Austria (2014)
- Fellowship Award
American Heart Association (2005-2006)
- Fellowship Award
State of Baden-Wuerttemberg, Germany (2000-2002)
- Research Stipend
Hoffman La Roche, Germany (2000)
TEMPUS, European Union (1998)
- American Society for Echocardiography (2015)
- American Society of Nuclear Cardiology (2015)
- International Society for Magnetic Resonance (2015)
- European Association of Cardiovascular Imaging (2014)
- Society for Cardiovascular Magnetic Resonance (2014)
- American College of Cardiology (2011)
- American Heart Association (2011)