Josephine Thinwa, M.D., Ph.D.
Assistant Professor
School Medical School
Department Internal Medicine | Microbiology
Graduate Programs Molecular Microbiology
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Biography
Josephine Thinwa, M.D., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Infectious Diseases and Geographic Medicine. She also holds a secondary appointment in the Department of Microbiology.
Originally from Kenya, Dr. Thinwa holds a bachelor's degree in biology with a chemistry minor from Southwestern University in Georgetown, Texas, where she graduated cum laude. She earned her combined medical and doctoral degrees, with doctoral studies in microbiology and immunology, from the University of Texas Health Science Center at San Antonio. She then completed residency training in internal medicine at UT Southwestern, followed by fellowship training in infectious diseases as part of the Physician Scientist Training Program. Her long-held interest in innate immunity and viruses led her to work as a postdoctoral researcher in the lab of Beth Levine, M.D., an international leader in autophagy research and Professor of Internal Medicine, who died in 2020.
Board certified by the American Board of Internal Medicine in both internal medicine and infectious diseases, she joined the UT Southwestern faculty in 2021.
Dr. Thinwa’s research focuses on autophagy, a natural cell-recycling process that helps cells break down and eliminate viruses and other unnecessary components. Her laboratory investigates how autophagy becomes activated by viruses that cause infections of the central nervous system. Her goal is to increase understanding on the role of autophagy in the immune response to viruses and, ultimately, to use this knowledge to develop new vaccines and treatments for an array of viruses.
In 2022, she received a Career Award for Medical Scientists from the Burroughs Wellcome Fund.
Education
- Graduate School
- University of Texas Health Science Center at San Antonio (2013)
- Other Post Graduate Training
- UT Health San Antonio (2013)
- Medical School
- University of Texas Health Science Center at San Antonio (2015)
- Residency
- UT Southwestern Medical Center (2017), Internal Medicine
- Fellowship
- UT Southwestern Medical Center (2019), Infectious Diseases
- Clinical Research Fellowship
- UT Southwestern Medical Center (2021)
Research Interest
- Autophagy
- Innate Immunity
- Neuroimmunology
- Viral Pathogenesis
Publications
Featured Publications
- CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses
- Thinwa JW, Zou Z, Parks E, Sebti S, Hui KK, Wei Y, Goodarzi M, Singh V, Urquhart G, Jewell JL, Pfeiffer JK, Levine B, Reese TA, Shiloh MU. J Clin Invest 2024
- Procyanidin C1 Modulates the Microbiome to Increase FOXO1 Signaling and Valeric Acid Levels to Protect the Mucosal Barrier in Inflammatory Bowel Disease
- Wang X, Wang P, Li Y, Guo H, Wang R, Liu S, Qiu J, Wang X, Hao Y, Zhao Y, Liao H, Zou Z, Thinwa J, Liu R Engineering 2024
- Risk factors for the development of active methicillin-resistant Staphylococcus aureus (MRSA) infection in patients colonized with MRSA at hospital admission.
- Cadena J, Thinwa J, Walter EA, Frei CR, Am J Infect Control 2016 12 44 12 1617-1621
- Integrin-mediated first signal for inflammasome activation in intestinal epithelial cells.
- Thinwa J, Segovia JA, Bose S, Dube PH, J Immunol 2014 Aug 193 3 1373-82
- Mitogen-activated protein kinase-dependent interleukin-1a intracrine signaling is modulated by YopP during Yersinia enterocolitica infection.
- Bose R, Thinwa J, Chaparro P, Zhong Y, Bose S, Zhong G, Dube PH, Infect Immun 2012 Jan 80 1 289-97
Books
Featured Books
Basic Science of Central Nervous System Infections. In Youmans and Winn Neurological Surgery, 8th Ed.
Thinwa, J and Tessier, J (). Elsevier
Honors & Awards
- Disease Oriented Clinical Scholars Award
UT Southwestern (2024) - Career Award for Medical Scientists
Burroughs Wellcome Fund (2022) - NIH K08 Clinical Scientist Research Career Development Award
National Institutes of Health (2021) - Translational Science Training Scholar
(2011)
Professional Associations/Affiliations
- American Physician Scientists Association
- Infectious Diseases Society of America