Biography

Dr. Ross’s research focuses on how cells receive, amplify, integrate, and sort information. The work focuses on the integrated control of cellular signaling pathways, particularly those that involve GTP-binding proteins.

Education

Undergraduate
University of California-Davis (1970), Biochemistry
Graduate School
Cornell University (1975), Biochemistry

Research Interest

  • Computational modeling of signaling networks
  • Integration of biological signaling
  • Interaction of membrane-bound enzymes and hormone receptors
  • Mechanisms of G protein-mediated signal transduction
  • Structure of G protein-coupled receptors

Publications

Featured Publications LegendFeatured Publications

Expression of human muscarinic cholinergic receptors in tobacco.
Mu JH, Chua NH, Ross EM Plant Mol. Biol. 1997 May 34 2 357-62
A Gs-selective analog of the receptor-mimetic peptide mastoparan binds to Gs alpha in a kinked helical conformation.
Sukumar M, Ross EM, Higashijima T Biochemistry 1997 Mar 36 12 3632-9
A GTPase-activating protein for the G protein Galphaz. Identification, purification, and mechanism of action.
Wang J, Tu Y, Woodson J, Song X, Ross EM J. Biol. Chem. 1997 Feb 272 9 5732-40
Carboxyl-terminal fragments of phospholipase C-beta1 with intrinsic Gq GTPase-activating protein (GAP) activity.
Paulssen RH, Woodson J, Liu Z, Ross EM J. Biol. Chem. 1996 Oct 271 43 26622-9
Purification and characterization of phospholipase C-beta 1 mutants expressed in E. coli.
Meij JT, Ross EM Biochem. Biophys. Res. Commun. 1996 Aug 225 3 705-11
Functional importance of the amino terminus of Gq alpha.
Hepler JR, Biddlecome GH, Kleuss C, Camp LA, Hofmann SL, Ross EM, Gilman AG J. Biol. Chem. 1996 Jan 271 1 496-504
The carboxyl-terminal anchorage domain of the turkey beta 1-adrenergic receptor is encoded by an alternatively spliced exon.
Wang J, Ross EM J. Biol. Chem. 1995 Mar 270 12 6488-95
Carboxyl-terminal domains in the avian beta 1-adrenergic receptor that regulate agonist-promoted endocytosis.
Parker EM, Swigart P, Nunnally MH, Perkins JP, Ross EM J. Biol. Chem. 1995 Mar 270 12 6482-7
Protein modification. Palmitoylation in G-protein signaling pathways.
Ross EM Curr. Biol. 1995 Feb 5 2 107-9
G protein GTPase-activating proteins: regulation of speed, amplitude, and signaling selectivity.
Ross EM Recent Prog. Horm. Res. 1995 50 207-21

Honors & Awards

  • NIGMS MERIT Award
    (2002)
  • ASPET Goodman and Gilman Award for Drug-Receptor Pharmacology
    (1996)
  • Chairman, Gordon Research Conference on Molecular Pharmacology
    (1991)
  • Scientific Director, NATO/FEBS Adv. Study Inst. on Biological Signal Transduction
    (1990)

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology
  • American Society for Pharmacology and Experimental Therapeutics (Section on Molecular Pharmacology)
  • Biophysical Society