Biography

Dr. Ross’s research focuses on how cells receive, amplify, integrate, and sort information. The work focuses on the integrated control of cellular signaling pathways, particularly those that involve GTP-binding proteins.

Education

Undergraduate
University of California-Davis (1970), Biochemistry
Graduate School
Cornell University (1975), Biochemistry

Research Interest

  • Computational modeling of signaling networks
  • Integration of biological signaling
  • Interaction of membrane-bound enzymes and hormone receptors
  • Mechanisms of G protein-mediated signal transduction
  • Structure of G protein-coupled receptors

Publications

Featured Publications LegendFeatured Publications

Binding of regulator of G protein signaling (RGS) proteins to phospholipid bilayers. Contribution of location and/or orientation to Gtpase-activating protein activity.
Tu Y, Woodson J, Ross EM J. Biol. Chem. 2001 Jun 276 23 20160-6
Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.
Tu Y, Popov S, Slaughter C, Ross EM J. Biol. Chem. 1999 Dec 274 53 38260-7
Reciprocal signaling between heterotrimeric G proteins and the p21-stimulated protein kinase.
Wang J, Frost JA, Cobb MH, Ross EM J. Biol. Chem. 1999 Oct 274 44 31641-7
Kinetic control of guanine nucleotide binding to soluble Galpha(q).
Chidiac P, Markin VS, Ross EM Biochem. Pharmacol. 1999 Jul 58 1 39-48
Phospholipase C-beta1 directly accelerates GTP hydrolysis by Galphaq and acceleration is inhibited by Gbeta gamma subunits.
Chidiac P, Ross EM J. Biol. Chem. 1999 Jul 274 28 19639-43
Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue.
Posner BA, Mukhopadhyay S, Tesmer JJ, Gilman AG, Ross EM Biochemistry 1999 Jun 38 24 7773-9
The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling.
Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, Danho W, Yagaloff KA, Fisher SL, Ross EM, Muallem S, Wilkie TM J. Biol. Chem. 1998 Dec 273 52 34687-90
Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity.
Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP, Ross EM, Gilman AG, Worley PF J. Neurosci. 1998 Sep 18 18 7178-88
PDZ domain proteins: scaffolds for signaling complexes.
Ranganathan R, Ross EM Curr. Biol. 1997 Dec 7 12 R770-3
Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits.
Tu Y, Wang J, Ross EM Science 1997 Nov 278 5340 1132-5

Honors & Awards

  • NIGMS MERIT Award
    (2002)
  • ASPET Goodman and Gilman Award for Drug-Receptor Pharmacology
    (1996)
  • Chairman, Gordon Research Conference on Molecular Pharmacology
    (1991)
  • Scientific Director, NATO/FEBS Adv. Study Inst. on Biological Signal Transduction
    (1990)

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology
  • American Society for Pharmacology and Experimental Therapeutics (Section on Molecular Pharmacology)
  • Biophysical Society