Dr. Ross’s research focuses on how cells receive, amplify, integrate, and sort information. The work focuses on the integrated control of cellular signaling pathways, particularly those that involve GTP-binding proteins.


Uni of California-Davis (1970), Biochemistry
Graduate School
Cornell University (1975), Biochemistry

Research Interest

  • Computational modeling of signaling networks
  • Integration of biological signaling
  • Interaction of membrane-bound enzymes and hormone receptors
  • Mechanisms of G protein-mediated signal transduction
  • Structure of G protein-coupled receptors


Featured Publications LegendFeatured Publications

Gß? Inhibits G?-GTPase-activating Proteins (GAPs) by Inhibition of Ga-GTP Binding during Stimulation by Receptor
Tang, W., Tu,Y., Nayak, S.K., Woodson J., Jehl, M. and Ross, E.M. J. Biol. Chem. 2006 281 4746-4753
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors.
Wang X, Zeng W, Soyombo AA, Tang W, Ross EM, Barnes AP, Milgram SL, Penninger JM, Allen PB, Greengard P, Muallem S Nat. Cell Biol. 2005 Apr 7 4 405-11
Uncoupling Conformational Change From GTP Hydrolysis In A Heterotrimeric G Protein alpha Subunit. Proc.
Thomas, C.J., Du, X., Li, P., Wang, Y., Ross, E.M., Sprang, S.R. Proc.Natl. Acad. Sci. March 2004 101 7560-7565
Phosphorylation-regulated inhibition of the Gz GTPase-activating protein activity of RGS proteins by synapsin I.
Tu Y, Nayak SK, Woodson J, Ross EM J. Biol. Chem. 2003 Dec 278 52 52273-81
Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities.
Shin DM, Dehoff M, Luo X, Kang SH, Tu J, Nayak SK, Ross EM, Worley PF, Muallem S J. Cell Biol. 2003 Jul 162 2 293-303
Mutations Of The Carboxyl Terminal Domain Of Phospholipase C-β1 Delineate The Dimer Interface And A Potential Gαq Interaction Site
Ilkaeva, O., Kinch, L.N., Paulssen, R.H., and Ross, E.M. J. Biol. Chem. February 2002 277 4294-4300
Mutations in the carboxyl-terminal domain of phospholipase C-beta 1 delineate the dimer interface and a potential Galphaq interaction site.
Ilkaeva O, Kinch LN, Paulssen RH, Ross EM J. Biol. Chem. 2002 Feb 277 6 4294-300
Quantitative assays for GTPase-activating proteins.
Ross EM Meth. Enzymol. 2002 344 601-17
Quench-flow kinetic measurement of individual reactions of G-protein-catalyzed GTPase cycle.
Mukhopadhyay S, Ross EM Meth. Enzymol. 2002 344 350-69
RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20.
Barker SA, Wang J, Sierra DA, Ross EM Genomics 2001 Dec 78 3 223-9

Honors & Awards

  • ASPET Goodman and Gilman Award for Drug-Receptor Pharmacology
  • Chairman, Gordon Research Conference on Molecular Pharmacology
  • Scientific Director, NATO/FEBS Adv. Study Inst. on Biological Signal Transduction

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology
  • American Society for Pharmacology and Experimental Therapeutics (Section on Molecular Pharmacology)
  • Biophysical Society