Dr. Ross’s research focuses on how cells receive, amplify, integrate, and sort information. The work focuses on the integrated control of cellular signaling pathways, particularly those that involve GTP-binding proteins.


University of California-Davis (1970), Biochemistry
Graduate School
Cornell University (1975), Biochemistry

Research Interest

  • Computational modeling of signaling networks
  • Integration of biological signaling
  • Interaction of membrane-bound enzymes and hormone receptors
  • Mechanisms of G protein-mediated signal transduction
  • Structure of G protein-coupled receptors


Featured Publications LegendFeatured Publications

Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells.
Wauson EM, Guerra ML, Dyachok J, McGlynn K, Giles J, Ross EM, Cobb MH Mol. Endocrinol. 2015 Aug 29 8 1114-1122
Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.
Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE J. Biol. Chem. 2011 Jan 286 2 942-51
Galpha(q) and phospholipase C-beta: turn on, turn off, and do it fast.
Ross EM Sci Signal 2011 4 159 pe5
Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway.
Jiang LI, Collins J, Davis R, Lin KM, DeCamp D, Roach T, Hsueh R, Rebres RA, Ross EM, Taussig R, Fraser I, Sternweis PC J. Biol. Chem. 2007 Apr 282 14 10576-84
Structural determinants for phosphatidic acid regulation of phospholipase C-beta1.
Ross EM, Mateu D, Gomes AV, Arana C, Tran T, Litosch I J. Biol. Chem. 2006 Nov 281 44 33087-94

Honors & Awards

  • ASPET Goodman and Gilman Award for Drug-Receptor Pharmacology
  • Chairman, Gordon Research Conference on Molecular Pharmacology
  • Scientific Director, NATO/FEBS Adv. Study Inst. on Biological Signal Transduction

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology
  • American Society for Pharmacology and Experimental Therapeutics (Section on Molecular Pharmacology)
  • Biophysical Society