Elliott Ross, Ph.D. Professor Emeritus School Medical School Department Office of the Provost | Pharmacology Biography Download Curriculum Vitae Dr. Ross’s research focuses on how cells receive, amplify, integrate, and sort information. The work focuses on the integrated control of cellular signaling pathways, particularly those that involve GTP-binding proteins. Education Undergraduate Uni of California-Davis (1970), Biochemistry Graduate School Cornell University (1975), Biochemistry Research Interest Computational modeling of signaling networks Integration of biological signaling Interaction of membrane-bound enzymes and hormone receptors Mechanisms of G protein-mediated signal transduction Structure of G protein-coupled receptors Publications Featured Publications Amino Acids Regulate mTORC1 by an Obligate Two-Step Mechanism. Dyachok J, Earnest S, Iturraran EN, Cobb MH, Ross EM J. Biol. Chem. 2016 Sep Intrinsic PH Domain Motion in Phospholipase C-? Exposes a G?? Binding Site. Kadamur G, Ross EM J. Biol. Chem. 2016 Mar Mammalian phospholipase C. Kadamur G, Ross EM Annu. Rev. Physiol. 2013 Feb 75 127-54 Activation biosensor for G protein-coupled receptors: a FRET-based m1 muscarinic activation sensor that regulates G(q). Chang S, Ross EM PLoS ONE 2012 7 9 e45651 WNK1 promotes PIP2 synthesis to coordinate growth factor and GPCR-Gq signaling. An SW, Cha SK, Yoon J, Chang S, Ross EM, Huang CL Curr. Biol. 2011 Dec 21 23 1979-87 Synergistic activation of phospholipase C-beta3 by Galpha(q) and Gbetagamma describes a simple two-state coincidence detector. Philip F, Kadamur G, Silos RG, Woodson J, Ross EM Curr. Biol. 2010 Aug 20 15 1327-35 Coordinating speed and amplitude in G-protein signaling. Ross EM Curr. Biol. 2008 Sep 18 17 R777-R783 Coordinate Regulation of G Protein Signaling via Dynamic Interactions of Receptor and GAP Turcotte, M., Tang, W., Ross, E.M. PLoS Computational Biology August 2008 4 e100148 GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Ross EM, Wilkie TM Annu. Rev. Biochem. 2000 69 795-827 Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins. Mukhopadhyay S, Ross EM Proc. Natl. Acad. Sci. U.S.A. 1999 Aug 96 17 9539-44 Results 1-10 of 78 1 2 3 4 5 Next Last Honors & Awards NIGMS MERIT Award (2002) ASPET Goodman and Gilman Award for Drug-Receptor Pharmacology (1996) Chairman, Gordon Research Conference on Molecular Pharmacology (1991) Scientific Director, NATO/FEBS Adv. Study Inst. on Biological Signal Transduction (1990) Professional Associations/Affiliations American Society for Biochemistry and Molecular Biology American Society for Pharmacology and Experimental Therapeutics (Section on Molecular Pharmacology) Biophysical Society
