Charles Rosenfeld, M.D.

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Dr. Rosenfeld attended college at Emory University and graduated from Emory University School of Medicine. He completed his general training in Pediatrics at Yale-New Haven Medical Center and Albert Einstein College of Medicine, where he also was Chief Resident. He then spent a year as a Pediatric Pulmonary Fellow with Amile Scarpelli, MD, PhD at Albert Einstein, followed by 2 years in the Perinatal Research Program at the University of Colorado Health Sciences Center under the mentoring of Frederick Battaglia, MD and Giacomo Meschia, MD. After joining the faculty at UT Southwestern in 1973, Dr. Rosenfeld established a perinatal biology laboratory for the study of cardiovascular changes in pregnancy, and in particular, the study of uteroplacental and umbilicoplacental blood flows. He has received nearly continuous funding from NIH for his studies of the mother and fetus for 39 years, as well as other grants, making contributions to our understanding of cardiovascular changes in pregnancy and during fetal and neonatal development. He was the Director of the Division of Neonatal-Perinatal Medicine for nearly 35 years and has provided research training and mentoring for more than 15 fellows in his specialty, 5 in Maternal-Fetal Medicine, and numerous postdoctoral and medical students. His publication record exceeds 200 peer-reviewed articles and chapters in several textbooks. Dr. Rosenfeld was the 2005 recipient of the Founders Award given by the Southern Society for Pediatric Research for his research contributions to child health and was elected a Fellow in the Section of Heart and Circulatory Physiology, American Physiological Society in 2005. He received a 2018 Albert Nelson Marquis Lifetime Achievement Award and was awarded Emeritus by the University of Texas March 2019.

Medical School

Emory University (1966)

• Blood pressure regulation before and after birth
• Cardiovascular role of estrogen in pregnancy
• Development of the renin-angiotensin system
• Mechanisms modulating uteroplacental blood flow

Featured Publications

Differential sensitivity to angiotensin II and norepinephrine in human uterine arteries.

Rosenfeld CR, DeSpain K, Word RA, Liu XT J. Clin. Endocrinol. Metab. 2012 Jan 97 1 138-47

Pregnancy modifies the large conductance Ca2+-activated K+ channel and cGMP-dependent signaling pathway in uterine vascular smooth muscle.

Rosenfeld CR, Liu XT, DeSpain K Am. J. Physiol. Heart Circ. Physiol. 2009 Jun 296 6 H1878-87

Ca(2+)-activated K(+) channels modulate basal and E(2)beta-induced rises in uterine blood flow in ovine pregnancy.

Rosenfeld CR, Cornfield DN, Roy T Am. J. Physiol. Heart Circ. Physiol. 2001 Jul 281 1 H422-31

Ontogeny of vascular angiotensin II receptor subtype expression in ovine development.

Cox BE, Rosenfeld CR Pediatr. Res. 1999 Mar 45 3 414-24

Effect of angiotensin II on uterine and systemic vasculature in pregnant sheep.

Naden RP, Rosenfeld CR J. Clin. Invest. 1981 Aug 68 2 468-74

Circulatory changes in the reproductive tissues of ewes during pregnancy.

Rosenfeld CR, Morriss FH, Makowski EL, Meschia G, Battaglia FC Gynecol Invest 1974 5 5-6 252-68

Valid serial length measurements in preterm infants permit characterization of growth patterns.

Pavageau L, Rosenfeld CR, Heyne R, Brown LS, Whitham J, Lair C, Brion LP J Perinatol 2018 Sep

Fetal-placental crosstalk occurs through fetal cytokine synthesis and placental clearance.

Mir IN, Chalak LF, Liao J, Johnson-Welch S, Brown LS, Longoria C, Savani RC, Rosenfeld CR Placenta 2018 Sep 69 1-8

Lenticulostriate vasculopathy in preterm infants: a new classification, clinical associations and neurodevelopmental outcome.

Sisman J, Chalak L, Heyne R, Pritchard M, Weakley D, Brown LS, Rosenfeld CR J Perinatol 2018 Aug

Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort.

Vohr BR, Heyne R, Bann CM, Das A, Higgins RD, Hintz SR J. Pediatr. 2018 May

 Featured Books

Regulation of the Placental Circulation. In Polin RA, Abman SH, Rowitch D, Benitz WE, eds. Fetal and Neonatal Physiology. 5th ed.

Rosenfeld CR. (2016). Philadelphia: Elsevier; 114-120.

Maternal Cardiovascular Alterations during Pregnancy. In Gluckman PS, Heymann MA, eds. Perinatal and Pediatric Pathophysiology: A Clinical Perspective.

Magness RR, Rosenfeld CR. (1993). London: Edward Arnold Publisher.

Eicosanoids and the Regulation of Uteroplacental Hemodynamics. In Mitchell MD, ed. Eicosanoids in Reproduction

Magness RR, Rosenfeld CR. (1990). CRC Press; 139-168.

• Albert Nelson Marquis Lifetime Achievement Award
  Marquis Who's Who Publications Board (2018)
• Top Doctors
  Castle Connolly Medical Ltd. (2014)
• Top Doctors
  US News & World Report (2012)
• Student Teaching Award, Senior Acute Care Medicine
  UT Southwestern Medical School (2008)
• Legends Award for Outstanding Service
  Parkland Memorial Hospital (2007)
• SSPR Founders Award
  Recognition for research contributing to improving child health, Southern Society of Pediatric Research (2005)
• Who's Who in America
  (2005)
• Associate Editor, Reproductive Sciences (JSGI)
  Appointed to the initial Editorial Board; evaluating basic research (1993-2018)
• George L. MacGregor Professorship of Pediatrics
  Recognition for research contributions in Perinatal Medicine (1993-2019)
• Associate Editor, Early Human Development
  Responsible for all manuscripts in the Americas (1986)
• Perinatal Research Society
  Recognition for contributions to studies in pregnancy and development (1981)

• American Pediatric Program Directors (2008-2010)
• American Heart Association (1999-2019)
• American Physiologic Society (1985-2019)
• American Pediatric Society (1983)
• Perinatal Research Society (1981)
• Society for Gynecologic Investigation (1978)
• Society for Pediatric Research (1977)
• American Academy of Pediatrics (1976)