Biography

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Peter Douglas, Ph.D., is an assistant professor in the Department of Molecular Biology at UT Southwestern Medical Center. He received his bachelor’s degree in Biochemistry from the University of Colorado in Boulder and earned his Ph.D. from the University of North Carolina in Chapel Hill in the Department of Cell and Developmental Biology. As a graduate student in the laboratory of Dr. Douglas Cyr, Peter used different methods in biochemistry, genetics, and cell biology to understand the mechanisms by which protein homeostasis machinery detoxifies misfolded, aggregation-prone proteins. In 2009, he joined the laboratory of Andrew Dillin at the Salk Institute in La Jolla, California, and later the University of California in Berkeley, California. There he uncovered novel links between classical stress response function and the actin cytoskeleton network. In 2015, Peter joined the faculty at UT Southwestern as an assistant professor in the Department of Molecular Biology. Peter was awarded fellowships from the American Heart Association, National Institute of Health on the Neuroplasticity of Aging and the George E. Hewitt Medical Foundation. He also received a Pathway to Independence Award (K99/R00) from the National Institute of Health. As an assistant professor, Peter received a Cancer Prevention Research Institute of Texas (CPRIT) recruitment of a first-time, tenure-track faculty member award and is an Endowed Scholar in biomedical research. 

Education

Undergraduate
Uni of Colorado-Boulder (2001), Biochemistry
Graduate School
University of N C-Chapel Hill (2009), Molecular & Cell Biology

Research Interest

  • Molecular Genetics of Aging
  • Protein Homeostasis
  • Stress Response Signaling
  • Traumatic Brain Injury

Publications

Featured Publications LegendFeatured Publications

The disposable soma theory of aging in reverse.
Douglas PM, Dillin A Cell Res. 2014 Jan 24 1 7-8
RPN-6 determines C. elegans longevity under proteotoxic stress conditions.
Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, Rodrigues AP, Manning G, Dillin A Nature 2012 Sep 489 7415 263-8
Protein homeostasis and aging in neurodegeneration.
Douglas PM, Dillin A J. Cell Biol. 2010 Sep 190 5 719-29
Interplay between protein homeostasis networks in protein aggregation and proteotoxicity.
Douglas PM, Cyr DM Biopolymers 2010 Mar 93 3 229-36
Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones.
Summers DW, Douglas PM, Ramos CH, Cyr DM Trends Biochem. Sci. 2009 May 34 5 230-3
Prion propagation by Hsp40 molecular chaperones.
Summers DW, Douglas PM, Cyr DM Prion 2009 Apr-Jun 3 2 59-64
Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways.
Douglas PM, Summers DW, Cyr DM Prion 2009 Apr-Jun 3 2 51-8
The type I Hsp40 Ydj1 utilizes a farnesyl moiety and zinc finger-like region to suppress prion toxicity.
Summers DW, Douglas PM, Ren HY, Cyr DM J. Biol. Chem. 2009 Feb 284 6 3628-39

Honors & Awards

  • Clayton Medical Foundation Investigator Award
    (2020)
  • NIH (R01) National Institute of Health Award
    (2019-2024)
  • American Federation of Aging Research (AFAR) Young Investigator Award
    (2017-2019)
  • Texas Institute of Brain Injury Research (TIBIR) Pilot Award
    (2017-2018)
  • Welch Foundation Award in Chemical Biology
    (2017-2020)
  • Glenn Award for Research in Biological Mechanisms of Aging
    (2016-2018)
  • Cancer Prevention Research Institute of Texas (CPRIT) Scholar Recruitment of First-Time, Tenure-Track Faculty Members
    (2015)
  • University of Texas Southwestern Medical Center Endowed Scholar
    (2015)
  • K99/R00 Pathway to Independence Award NIH/NIA
    (2013-2018)
  • George Hewitt Medical Foundation Scholar
    (2010-2013)
  • Neuroplasticity of Aging Postdoctoral Training Fellowship
    (2009-2010)
  • American Heart Association Pre-Doctoral Fellowship
    (2006-2008)

Professional Associations/Affiliations

  • Hamon Center for Regenerative Science and Medicine (2015)