Peter Douglas, Ph.D., is an assistant professor in the Department of Molecular Biology at UT Southwestern Medical Center. He received his bachelor’s degree in Biochemistry from the University of Colorado in Boulder and earned his Ph.D. from the University of North Carolina in Chapel Hill in the Department of Cell and Developmental Biology. As a graduate student in the laboratory of Dr. Douglas Cyr, Peter used different methods in biochemistry, genetics, and cell biology to understand the mechanisms by which protein homeostasis machinery detoxifies misfolded, aggregation-prone proteins. In 2009, he joined the laboratory of Andrew Dillin at the Salk Institute in La Jolla, California, and later the University of California in Berkeley, California. There he uncovered novel links between classical stress response function and the actin cytoskeleton network. In 2015, Peter joined the faculty at UT Southwestern as an assistant professor in the Department of Molecular Biology. Peter was awarded fellowships from the American Heart Association, National Institute of Health on the Neuroplasticity of Aging and the George E. Hewitt Medical Foundation. He also received a Pathway to Independence Award (K99/R00) from the National Institute of Health. As an assistant professor, Peter received a Cancer Prevention Research Institute of Texas (CPRIT) recruitment of a first-time, tenure-track faculty member award and is an Endowed Scholar in biomedical research.
- Uni of Colorado-Boulder (2001), Biochemistry
- Graduate School
- University of N C-Chapel Hill (2009), Molecular & Cell Biology
- Molecular Genetics of Aging
- Protein Homeostasis
- Stress Response Signaling
- Traumatic Brain Injury
- Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress.
- Nathan Egge, Sonja L. B. Arneaud, Rene Solano Fonseca, Kielen R. Zuurbier, Jacob McClendon, Peter M. Douglas Nat Commun 2021 12 1484
- Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.
- Egge N, Arneaud SLB, Wales P, Mihelakis M, McClendon J, Fonseca RS, Savelle C, Gonzalez I, Ghorashi A, Yadavalli S, Lehman WJ, Mirzaei H, Douglas PM, Dev Cell 2019 12 51 5 587-601.e7
- Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity.
- Douglas PM, Baird NA, Simic MS, Uhlein S, McCormick MA, Wolff SC, Kennedy BK, Dillin A Cell Rep 2015 Aug
- HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span.
- Baird NA, Douglas PM, Simic MS, Grant AR, Moresco JJ, Wolff SC, Yates JR, Manning G, Dillin A Science 2014 Oct 346 6207 360-3
- Reciprocal efficiency of RNQ1 and polyglutamine detoxification in the cytosol and nucleus.
- Douglas PM, Summers DW, Ren HY, Cyr DM Mol. Biol. Cell 2009 Oct 20 19 4162-73
- Chaperone-dependent amyloid assembly protects cells from prion toxicity.
- Douglas PM, Treusch S, Ren HY, Halfmann R, Duennwald ML, Lindquist S, Cyr DM Proc. Natl. Acad. Sci. U.S.A. 2008 May 105 20 7206-11
- Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones.
- Ramadurgum P, Woodard DR, Daniel S, Peng H, Mallipeddi PL, Niederstrasser H, Mihelakis M, Chau VQ, Douglas PM, Posner BA, Hulleman JD, Cell Chem Biol 2020 Mar
- Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.
- Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Olswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA Nat Commun 2017 Dec 8 1 2270
- The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.
- Das R, Melo JA, Thondamal M, Morton EA, Cornwell AB, Crick B, Kim JH, Swartz EW, Lamitina T, Douglas PM, Samuelson AV PLoS Genet. 2017 Oct 13 10 e1007038
- The Stress Response Paradox: Fighting Degeneration at the Cost of Cancer.
- Arneaud SL, Douglas PM FEBS J. 2016 May
Honors & Awards
- Clayton Medical Foundation Investigator Award
- NIH (R01) National Institute of Health Award
- American Federation of Aging Research (AFAR) Young Investigator Award
- Texas Institute of Brain Injury Research (TIBIR) Pilot Award
- Welch Foundation Award in Chemical Biology
- Glenn Award for Research in Biological Mechanisms of Aging
- Cancer Prevention Research Institute of Texas (CPRIT) Scholar Recruitment of First-Time, Tenure-Track Faculty Members
- University of Texas Southwestern Medical Center Endowed Scholar
- K99/R00 Pathway to Independence Award NIH/NIA
- George Hewitt Medical Foundation Scholar
- Neuroplasticity of Aging Postdoctoral Training Fellowship
- American Heart Association Pre-Doctoral Fellowship
- Hamon Center for Regenerative Science and Medicine (2015)