Vincent (Vinnie) Tagliabracci is an Assistant Professor in the Department of Molecular Biology at UT Southwestern Medical Center. He received his B.S. in Chemistry and Biology from the University of Indianapolis and his Ph.D. in Biochemistry and Molecular Biology from Indiana University under the supervision of Dr. Peter Roach, where he made several important contributions to understanding how elevated levels of glycogen phosphate cause Lafora Disease, a deadly form of epilepsy. In 2010, Vinnie joined the laboratory of Dr. Jack Dixon as a postdoctoral fellow at the University of California, San Diego in La Jolla, CA. There, he discovered a novel family of “secreted” kinases that phosphorylate proteins destined for secretion from the cell. As part of this work, he identified Fam20C as the bona fide "Golgi casein kinase", an enzyme that escaped identification for many years. In 2015, he joined the faculty at UT Southwestern as an Assistant Professor in the Department of Molecular Biology. Vinnie is the recipient of the Esther L. Kinsley dissertation award from Indiana University School of Medicine, a K99/R00 Pathway to Independence award from the National Institutes of Health, a Cancer Prevention Research Institute of Texas (CPRIT) recruitment of first-time, tenure-track faculty member award and is an Endowed Scholar in biomedical research.
- University of Indianapolis (2005), Chemistry
- University of Indianapolis (2005), Biology
- Graduate School
- Indiana Univ Purdue Univ Sch M (2010), Molecular Biology
- Graduate School
- Indiana Univ Purdue Univ Sch M (2010), Biochemistry
- Cancer Biology
- CRISPR Genome Editing
- Kinases in the Secretory Pathway and Extracellular Space
- Phosphorylation of Secreted Proteins
- Signal Transduction
- A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity.
- Lopez VA, Park BC, Nowak D, Sreelatha A, Zembek P, Fernandez J, Servage KA, Gradowski M, Hennig J, Tomchick DR, Pawlowski K, Krzymowska M, Tagliabracci VS, Cell 2019 Sep
- Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases.
- Black MH, Osinski A, Gradowski M, Servage KA, Pawlowski K, Tomchick DR, Tagliabracci VS, Science 2019 May 364 6442 787-792
- Protein AMPylation by an Evolutionarily Conserved Pseudokinase.
- Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbanska M, Lobocka M, Grishin NV, Orth K, Kucharczyk R, Pawlowski K, Tomchick DR, Tagliabracci VS Cell 2018 Oct 175 3 809-821.e19
- Phosphorylation of spore coat proteins by a family of atypical protein kinases.
- Nguyen KB, Sreelatha A, Durrant ES, Lopez-Garrido J, Muszewska A, Dudkiewicz M, Grynberg M, Yee S, Pogliano K, Tomchick DR, Pawlowski K, Dixon JE, Tagliabracci VS Proc. Natl. Acad. Sci. U.S.A. 2016 May
- A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
- Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE Cell 2015 Jun 161 7 1619-32
- Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis.
- Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Koller A, Nizet V, White KE, Dixon JE Proc. Natl. Acad. Sci. U.S.A. 2014 Apr 111 15 5520-5
- Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.
- Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby CA, Kinch LN, Xiao J, Grishin NV, Dixon JE Science 2012 Jun 336 6085 1150-3
- Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals.
- Park BC, Reese M, Tagliabracci VS, IUBMB Life 2019 Jun 71 6 749-759
- The Golgi 'casein kinase' Fam20C is a genuine 'phosvitin kinase' and phosphorylates polyserine stretches devoid of the canonical consensus.
- Cozza G, Moro E, Black M, Marin O, Salvi M, Venerando A, Tagliabracci VS, Pinna LA FEBS J. 2018 Dec 285 24 4674-4683
- The secretory pathway kinases.
- Sreelatha A, Kinch LN, Tagliabracci VS Biochim. Biophys. Acta 2015 Apr
Honors & Awards
- NIH Director's New Innovator Award (DP2)
- Searle Scholar
- ASBMB Herb Tabor Junior Investigator Award
- ASMB Junior Investigator Award
- Cancer Prevention Research Institute of Texas (CPRIT) Scholar
- UT Southwestern Endowed Scholar
- K99/R00 Pathway to Independence Award
- Esther L. Kinsley PhD Dissertation Award