Milo Lin, Ph.D.

Since 2021, Milo Lin has been appointed as assistant professor in the Lyda Hill Department of Bioinformatics. Since 2015, he is also a member of the Cecil H. and Ida Green Center for Systems Biology. He is the Cecil H. and Ida M. Green Endowed Scholar in Biomedical Computational Science. Milo Lin received his B.S. and Ph.D. in physics from Caltech in 2006 and 2012, respectively. His thesis work, under the mentorship of Ahmed Zewail, was on physical principles of protein folding. He was a Miller Independent Research Fellow, hosted by David Chandler, at UC Berkeley from 2012-2015.

Undergraduate

California Inst of Technology (2006), Physics

Graduate School

California Inst of Technology (2012), Physics

• Using statistical physics, interpretable deep learning, and molecular simulations, the Lin lab seeks design principles that constrain and modularize the behavior of biological systems. Current projects in the lab include predicting and designing information flow and allostery within proteins, generating truly de novo protein sequences for specified functions, and mapping biomolecular dynamics to the mathematical domain of scalable electronic circuits.

Featured Publications

Explainable neural networks that simulate reasoning

Paul J. Blazek, Milo M. Lin Nat Comp Sci 2021 1 607-618

Timing Correlations in Proteins Predict Functional Modules and Dynamic Allostery.

Lin MM J. Am. Chem. Soc. 2016 Mar

Hydrophobic forces and the length limit of foldable protein domains.

Lin MM, Zewail AH Proc. Natl. Acad. Sci. U.S.A. 2012 Jun 109 25 9851-6

Speed limit of protein folding evidenced in secondary structure dynamics.

Lin MM, Mohammed OF, Jas GS, Zewail AH Proc. Natl. Acad. Sci. U.S.A. 2011 Oct 108 40 16622-7

Full Publication List

• Clauser Doctoral Prize
  Best PhD thesis over all fields as judged by originality and potential intellectual impact (2012-2012)
• Miller Research Fellow
  Independent postdoctoral fellow hosted at UC Berkeley (2012-2015)

• Center for Alzheimer's and Neurodegenerative Diseases (2016)
• Dept. of Biophysics (2015)
• Green Center for Systems Biology (2015)
• Lyda Hill Department of Bioinformatics (2021)