Liyuan Chen, Ph.D., Assistant Professor in the Department of Radiation Oncology, earned her doctorate degree from Hong Kong Baptist University. After graduation, she started a postdoctoral research fellow position at UT Southwestern Medical Center, followed by completion of her clinical training in UT Southwestern’s Medical Physics Residency Program where she served as chief resident during her second year.

Dr. Chen's research interests include medical image reconstruction and processing, inverse treatment planning, and treatment outcome prediction.

Research Interest

  • Inverse treatment planning
  • Medical image processing: denoising, deblurring, segmentation, classification, and registration
  • Medical image reconstruction
  • Treatment outcome prediction


Zero-Shot Medical Image Translation via Frequency-Guided Diffusion Models
Li Y, Shao HC, Liang X, Chen L, Li R, Jiang S, Wang J, Zhang Y IEEE Transactions on Medical Imaging 2024 Mar 43 980-993
Joint Vestibular Schwannoma Enlargement Prediction and Segmentation Using a Deep Multi-task Model
Wang K, George-Jones NA, Chen L, Hunter JB, Wang J Laryngoscope 2023 Oct 133 2754-2760
Efficacy and Quality-of-Life Following Involved Nodal Radiotherapy for Head and Neck Squamous Cell Carcinoma: The INRT-AIR Phase II Clinical Trial
Sher DJ, Moon DH, Vo D, Wang J, Chen L, Dohopolski M, Hughes R, Sumer BD, Ahn C, Avkshtol V Clinical Cancer Research 2023 Sep 29 3284-3291
ARMO: automated and reliable multi-objective model for lymph node metastasis prediction in head and neck cancer
Zhou Z, Chen L, Dohopolski M, Sher D, Wang J Physics in medicine and biology 2023 May 68
Clinical experience on patient-specific quality assurance for CBCT-based online adaptive treatment plan
Shen C, Chen L, Zhong X, Gonzalez Y, Visak J, Meng B, Inam E, Parsons D, Godley A, Jiang S, Cai B, Lin MH Journal of applied clinical medical physics 2023 Apr 24
Case study: Lymph node malignancy classification for head and neck cancer radiation therapy
Wang J, Chen L, Dohopolski M, Sher D 2023 Jan 401-423
Attention Guided Lymph Node Malignancy Prediction in Head and Neck Cancer
Chen L, Dohopolski M, Zhou Z, Wang K, Wang R, Sher D, Wang J International Journal of Radiation Oncology Biology Physics 2021 Jul 110 1171-1179
A hierarchical deep reinforcement learning framework for intelligent automatic treatment planning of prostate cancer intensity modulated radiation therapy
Shen C, Chen L, Jia X Physics in medicine and biology 2021 Jul 66
Synthetic CT generation from CBCT images via unsupervised deep learning
Chen L, Liang X, Shen C, Nguyen D, Jiang S, Wang J Physics in medicine and biology 2021 Jun 66
Improving efficiency of training a virtual treatment planner network via knowledge-guided deep reinforcement learning for intelligent automatic treatment planning of radiotherapy
Shen C, Chen L, Gonzalez Y, Jia X Medical physics 2021 Apr 48 1909-1920

Honors & Awards

  • Interdisciplinary Contest In Modeling – Meritorious Winner

Professional Associations/Affiliations

  • American Association of Physicists in Medicine (AAPM) (2021)
  • American Society of Radiation Oncology (ASTRO) (2021)