Biography

Joseph A. Maldjian, MD, is Professor of Radiology at UT Southwestern, and serves as Chief of the Neuroradiology Division and Director of the Advanced Neuroscience Imaging Research Lab. His clinical interests involve bringing novel imaging methodologies and advanced analysis methods into the clinical setting.

What I really appreciate about neuroradiology at UT Southwestern is the perfect partnering of clinical and research excellence.

After receiving his bachelor’s degree in biochemistry from Princeton University, Dr. Maldjian earned his medical degree from the University of Medicine and Dentistry of New Jersey in Newark. He completed his residency training in diagnostic radiology at Mount Sinai Medical Center in New York, and then received advanced training in neuroradiology through a two-year fellowship at the University of Pennsylvania School of Medicine in Philadelphia.

Before joining the faculty at UT Southwestern, Dr. Maldjian served as a Professor of Radiology and Biomedical Engineering at Wake Forest University School of Medicine in Winston-Salem, North Carolina. Prior to that, he held faculty appointments at the Hospital of the University of Pennsylvania, and at New Jersey Medical School.

Investigating traumatic brain injuries

Dr. Maldjian’s research team has been instrumental in bringing arterial spin-labeling (ASL) into routine clinical practice. This noninvasive method “tags” arterial blood water through a process of magnetic inversion, making it possible for a magnetic resonance imaging (MRI) scanner to detect the “magnetized” blood flowing through brain tissue. He has also developed fully automated means for processing, archiving and analyzing these images, as well as images obtained using functional MRI, diffusion tensor imaging, positron emission tomography, and magnetoencephalography (MEG). Dr. Maldjian’s research lab maintains a data processing resource that can handle large amounts of neuroimaging data and provide an interface to an array of commonly used software platforms.

The main focus of Dr. Maldjian’s research is sports-related, mild traumatic brain injury. He is currently one of only a few radiologists in the nation to serve as principal investigator on three active National Institutes of Health (NIH)-funded R01 studies. Dr. Maldjian and his collaborators are studying the effects of sub-concussive impacts on youth and high school football players by obtaining MRI, MEG, cognitive measures and detailed head impact data from sensors embedded in players’ helmets.

He is also investigating whether genetic and racial factors related to diabetes might lead to changes in the brain structure and function in African-Americans.

Dr. Maldjian is an active member of numerous national and international societies, including the International Society for Magnetic Resonance in Medicine, American Society of Neuroradiology, American Society for Functional Neuroradiology, American College of Radiology, American Board of Radiology, and the Radiological Society of North America.

Robust editorial activity

In addition to authoring more than 125 peer-reviewed publications and over 15 additions to textbooks, Dr. Maldjian is a reviewer for multiple academic journals, including Radiology, Neuroradiology, Neurology, Neuroimage, Clinical Neuroradiology, American Journal of Neuroradiology, Annals of Biomedical Engineering, Neuroinformatics, and Journal of Computer Assisted Tomography. He also serves as a charter member of the NIH Biomedical Imaging Technology Study Section A.

Personal note

Dr. Maldjian is a trained classical pianist who spends much of his free time with his wife designing, testing, and optimizing novel reward systems to get their four young children to practice the instrument.

Education

Medical School
University of Medicine and Dentistry - New Jersey Medical School (1988)
Internship
St Barnabas Medical Center (1989), Internal Medicine
Residency
Icahn School of Medicine at Mount Sinai (1993), Diagnostic Radiology
Fellowship
Hospital of the University of Pennsylvania (1995), Neuroradiology

Research Interest

  • Advanced Neuroimaging Applications
  • Neuroimaging Analysis Pipelines
  • Resting State Magnetoencephalography (MEG) Analyses
  • Sports-Related Mild Traumatic Brain Injury

Publications

Featured Publications LegendFeatured Publications

High dimensional classification of structural MRI Alzheimer's disease data based on large scale regularization.
Casanova R, Whitlow CT, Wagner B, Williamson J, Shumaker SA, Maldjian JA, Espeland MA Front Neuroinform 2011 5 22
Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications.
Bowden DW, Cox AJ, Freedman BI, Hugenschimdt CE, Wagenknecht LE, Herrington D, Agarwal S, Register TC, Maldjian JA, Ng MC, Hsu FC, Langefeld CD, Williamson JD, Carr JJ Rev Diabet Stud 2010 7 3 188-201
Brain volumes, cognitive impairment, and conjugated equine estrogens.
Espeland MA, Tindle HA, Bushnell CA, Jaramillo SA, Kuller LH, Margolis KL, Mysiw WJ, Maldjian JA, Melhem ER, Resnick SM J. Gerontol. A Biol. Sci. Med. Sci. 2009 Dec 64 12 1243-50
The effect of daily caffeine use on cerebral blood flow: How much caffeine can we tolerate?
Addicott MA, Yang LL, Peiffer AM, Burnett LR, Burdette JH, Chen MY, Hayasaka S, Kraft RA, Maldjian JA, Laurienti PJ Hum Brain Mapp 2009 Oct 30 10 3102-14
A fast, effective filtering method for improving clinical pulsed arterial spin labeling MRI.
Tan H, Maldjian JA, Pollock JM, Burdette JH, Yang LY, Deibler AR, Kraft RA J Magn Reson Imaging 2009 May 29 5 1134-9
Arterial spin-labeled MR perfusion imaging: clinical applications.
Pollock JM, Tan H, Kraft RA, Whitlow CT, Burdette JH, Maldjian JA Magn Reson Imaging Clin N Am 2009 May 17 2 315-38
Evaluating the impact of spatio-temporal smoothness constraints on the BOLD hemodynamic response function estimation: an analysis based on Tikhonov regularization.
Casanova R, Yang L, Hairston WD, Laurienti PJ, Maldjian JA Physiol Meas 2009 May 30 5 N37-51
Pulsed arterial spin-labeled MR imaging evaluation of tuberous sclerosis.
Pollock JM, Whitlow CT, Tan H, Kraft RA, Burdette JH, Maldjian JA AJNR Am J Neuroradiol 2009 Apr 30 4 815-20
Multicenter, double-blind, randomized, intra-individual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine in MRI of brain tumors at 3 tesla.
Rumboldt Z, Rowley HA, Steinberg F, Maldjian JA, Ruscalleda J, Gustafsson L, Bastianello S J Magn Reson Imaging 2009 Apr 29 4 760-7
Hypercapnia-induced cerebral hyperperfusion: an underrecognized clinical entity.
Pollock JM, Deibler AR, Whitlow CT, Tan H, Kraft RA, Burdette JH, Maldjian JA AJNR Am J Neuroradiol 2009 Feb 30 2 378-85

Honors & Awards

  • Best Paper Trainee (Co-Author)
    American Society of Neuroradiology (2014)
  • Graduate Design and Research Award (Co-Author)
    Biomedical Engineering Society (2014)
  • Best Poster (Co-Author)
    American Society of Functional Neuroradiology (2012)
  • Outstanding Teacher
    International Society for Magnetic Resonance in Medicine (2009)
  • Derek Harwood-Nash Award (co-author), Outstanding Presentation Award in Pediatric Neuroradiology
    American Society of Neuroradiology (2008)
  • Best Doctors in America
    U.S. News & World Report (2005-2015)
  • Rennick Award (co-author)
    International Neuropsychological Society (2001)
  • American Roentgen Ray Society Scholar
    American Roentgen Ray Society (1999)
  • Sanofi-Winthrop Fellow in Neuroradiology
    Hospital of the University of Pennsylvania (1993)
  • Chief Resident, Department of Radiology
    Mount Sinai Medical Center, New York (1992)
  • Magna Cum Laude, Biochemistry
    Princeton University (1984)

Professional Associations/Affiliations

  • American Board of Radiology
  • American College of Radiology
  • American Society for Functional Neuroradiology
  • American Society of Neuroradiology
  • International Society for Magnetic Resonance in Medicine
  • Radiological Society of North America